Journal article 852 views 231 downloads
Effects of the cross-linkers on the buckling of microtubules in cells
Journal of Biomechanics, Volume: 72, Pages: 167 - 172
Swansea University Authors:
Chengyuan Wang , Perumal Nithiarasu
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DOI (Published version): 10.1016/j.jbiomech.2018.03.002
Abstract
In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the...
Published in: | Journal of Biomechanics |
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ISSN: | 00219290 |
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2018
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URI: | https://cronfa.swan.ac.uk/Record/cronfa38961 |
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2018-05-08T15:21:42.5676406 v2 38961 2018-03-07 Effects of the cross-linkers on the buckling of microtubules in cells fdea93ab99f51d0b3921d3601876c1e5 0000-0002-1001-2537 Chengyuan Wang Chengyuan Wang true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2018-03-07 MECH In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the two-dimensional-linkers were replaced by the three-dimensional (3D) ones. Then, the effects of the radial orientation and the axial density of the 3D-linkers were examined, showing that more uniform distribution of the radial orientation leads to the higher critical load with 3D buckling modes, while the inhomogeneity of the axial density results in the localized buckling patterns. The results demonstrated the important role of the cross-linker in regulating MT stiffness, revealed the physics of the experimentally observed localized buckling and these results will pave the way to a new multi-component mechanics model for whole cells. Journal Article Journal of Biomechanics 72 167 172 00219290 Microtubules; 3D localized buckling; Protein cross-linkers; Local density of linkers 31 12 2018 2018-12-31 10.1016/j.jbiomech.2018.03.002 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2018-05-08T15:21:42.5676406 2018-03-07T09:00:42.2233574 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Si Li 1 Chengyuan Wang 0000-0002-1001-2537 2 Perumal Nithiarasu 0000-0002-4901-2980 3 0038961-15032018092939.pdf li2018(3).pdf 2018-03-15T09:29:39.7070000 Output 1759879 application/pdf Accepted Manuscript true 2019-03-12T00:00:00.0000000 true eng |
title |
Effects of the cross-linkers on the buckling of microtubules in cells |
spellingShingle |
Effects of the cross-linkers on the buckling of microtubules in cells Chengyuan Wang Perumal Nithiarasu |
title_short |
Effects of the cross-linkers on the buckling of microtubules in cells |
title_full |
Effects of the cross-linkers on the buckling of microtubules in cells |
title_fullStr |
Effects of the cross-linkers on the buckling of microtubules in cells |
title_full_unstemmed |
Effects of the cross-linkers on the buckling of microtubules in cells |
title_sort |
Effects of the cross-linkers on the buckling of microtubules in cells |
author_id_str_mv |
fdea93ab99f51d0b3921d3601876c1e5 3b28bf59358fc2b9bd9a46897dbfc92d |
author_id_fullname_str_mv |
fdea93ab99f51d0b3921d3601876c1e5_***_Chengyuan Wang 3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu |
author |
Chengyuan Wang Perumal Nithiarasu |
author2 |
Si Li Chengyuan Wang Perumal Nithiarasu |
format |
Journal article |
container_title |
Journal of Biomechanics |
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72 |
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2018 |
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Swansea University |
issn |
00219290 |
doi_str_mv |
10.1016/j.jbiomech.2018.03.002 |
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Faculty of Science and Engineering |
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Faculty of Science and Engineering |
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Faculty of Science and Engineering |
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School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering |
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description |
In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the two-dimensional-linkers were replaced by the three-dimensional (3D) ones. Then, the effects of the radial orientation and the axial density of the 3D-linkers were examined, showing that more uniform distribution of the radial orientation leads to the higher critical load with 3D buckling modes, while the inhomogeneity of the axial density results in the localized buckling patterns. The results demonstrated the important role of the cross-linker in regulating MT stiffness, revealed the physics of the experimentally observed localized buckling and these results will pave the way to a new multi-component mechanics model for whole cells. |
published_date |
2018-12-31T03:49:27Z |
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1763752402823938048 |
score |
11.021648 |