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The photoreactive free radical in eumelanin

Bernard Mostert Orcid Logo, Shermiyah B. Rienecker, Christopher Noble, Graeme R. Hanson, Paul Meredith Orcid Logo

Science Advances, Volume: 4, Issue: 3, Start page: eaaq1293

Swansea University Authors: Bernard Mostert Orcid Logo, Paul Meredith Orcid Logo

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DOI (Published version): 10.1126/sciadv.aaq1293

Abstract

Melanin is the primary photoprotecting pigment in humans as well as being implicated in the development of deadly melanoma. The material also conducts electricity and has thus become a bioelectronic model for proton-to-electron transduction. Central to these phenomena are its spin properties—notably...

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Published in: Science Advances
ISSN: 2375-2548
Published: American Association for the Advancement of Science (AAAS) 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa39310
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Abstract: Melanin is the primary photoprotecting pigment in humans as well as being implicated in the development of deadly melanoma. The material also conducts electricity and has thus become a bioelectronic model for proton-to-electron transduction. Central to these phenomena are its spin properties—notably two linked species derived from carbon-centered and semiquinone radicals. Using a novel in situ photoinduced electron paramagnetic resonance technique with simultaneous electrical measurements, we have elucidated for the first time the distinct photoreactivity of the two different radical species. We find that the production of the semiquinone is light- and water-driven, explaining the electrical properties and revealing biologically relevant photoreactivity.
College: College of Science
Issue: 3
Start Page: eaaq1293