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Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation. / Oliver James Puckering

Swansea University Author: Oliver James Puckering

Abstract

This thesis deals with assessment of effects on thrombus structure brought about by the addition of carbon nanoparticles to blood in vitro. Chapter 1 outlines the development of the rheological discipline and discusses viscoelastic systems. Whole blood is a transient viscoelastic system. Methods of...

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Published: 2009
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
URI: https://cronfa.swan.ac.uk/Record/cronfa42700
first_indexed 2018-08-02T18:55:20Z
last_indexed 2018-08-03T10:10:52Z
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recordtype RisThesis
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spelling 2018-08-02T16:24:30.1646016 v2 42700 2018-08-02 Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation. 28db0c3381c86dd78dbc38479352aea8 NULL Oliver James Puckering Oliver James Puckering true true 2018-08-02 This thesis deals with assessment of effects on thrombus structure brought about by the addition of carbon nanoparticles to blood in vitro. Chapter 1 outlines the development of the rheological discipline and discusses viscoelastic systems. Whole blood is a transient viscoelastic system. Methods of locating the point of this change, the gel point, are discussed and briefly evaluated. In Chapter 2 the development of fractal analysis is investigated and the method by which a phase angle measured at the gel point can be converted into a fractal dimension is outlined. Carbon nanoparticles are discussed in Chapter 3 along with their methods of generation and an outline of the research into any associated health effects which has been carried out. The means by which the nanoparticles, both individually and in suspension, can be assessed are outlined in Chapter 4. Tests which were carried out to determine the best solvent for this work are outlined and the results discussed. Chapter 5 concerns blood and the cardiovascular system. The means by which thrombus generation and removal occur are discussed together with the TEG and Sonoclot clinical systems used to analyse haemostasis. Chapter 6 states the hypotheses to be investigated in this work. In Chapter 7 the materials and methods for the production of suspensions, their inclusion into extracted whole blood and the measurements taken on the resulting blood sample are outlined. Chapters 8-12 present the results from each of the nanoparticles investigated. Chapter 13 presents the conclusions drawn from the comparison of the results and discussions in Chapters 8-12. The most important of these conclusions is the order of effect of the nanoparticles on the blood: MCOOH > SCOOH > LPMN > LPSN > DIESEL. E-Thesis Biomedical engineering.;Nanotechnology. 31 12 2009 2009-12-31 COLLEGE NANME Engineering COLLEGE CODE Swansea University Doctoral Ph.D 2018-08-02T16:24:30.1646016 2018-08-02T16:24:30.1646016 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Oliver James Puckering NULL 1 0042700-02082018162515.pdf 10807469.pdf 2018-08-02T16:25:15.0770000 Output 23038215 application/pdf E-Thesis true 2018-08-02T16:25:15.0770000 false
title Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation.
spellingShingle Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation.
Oliver James Puckering
title_short Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation.
title_full Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation.
title_fullStr Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation.
title_full_unstemmed Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation.
title_sort Blood clot microstructures: The role of engineered and combustion derived carbon particulates in thrombus formation.
author_id_str_mv 28db0c3381c86dd78dbc38479352aea8
author_id_fullname_str_mv 28db0c3381c86dd78dbc38479352aea8_***_Oliver James Puckering
author Oliver James Puckering
author2 Oliver James Puckering
format E-Thesis
publishDate 2009
institution Swansea University
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 1
active_str 0
description This thesis deals with assessment of effects on thrombus structure brought about by the addition of carbon nanoparticles to blood in vitro. Chapter 1 outlines the development of the rheological discipline and discusses viscoelastic systems. Whole blood is a transient viscoelastic system. Methods of locating the point of this change, the gel point, are discussed and briefly evaluated. In Chapter 2 the development of fractal analysis is investigated and the method by which a phase angle measured at the gel point can be converted into a fractal dimension is outlined. Carbon nanoparticles are discussed in Chapter 3 along with their methods of generation and an outline of the research into any associated health effects which has been carried out. The means by which the nanoparticles, both individually and in suspension, can be assessed are outlined in Chapter 4. Tests which were carried out to determine the best solvent for this work are outlined and the results discussed. Chapter 5 concerns blood and the cardiovascular system. The means by which thrombus generation and removal occur are discussed together with the TEG and Sonoclot clinical systems used to analyse haemostasis. Chapter 6 states the hypotheses to be investigated in this work. In Chapter 7 the materials and methods for the production of suspensions, their inclusion into extracted whole blood and the measurements taken on the resulting blood sample are outlined. Chapters 8-12 present the results from each of the nanoparticles investigated. Chapter 13 presents the conclusions drawn from the comparison of the results and discussions in Chapters 8-12. The most important of these conclusions is the order of effect of the nanoparticles on the blood: MCOOH > SCOOH > LPMN > LPSN > DIESEL.
published_date 2009-12-31T04:24:38Z
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score 11.099239

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