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Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour. / Aled Huws Bryant

Swansea University Author: Aled Huws Bryant

Abstract

SummaryInterest in the innate immune response at the maternal-fetal interface has developeddue to the association between intrauterine infection, inflammation and adversepregnancy outcomes. Pattern recognition receptors (PRRs) offer a link betweenmicrobial derived agonists and the production of infl...

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Published: 2014
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
URI: https://cronfa.swan.ac.uk/Record/cronfa42934
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first_indexed 2018-08-02T18:55:53Z
last_indexed 2019-10-21T16:48:43Z
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spelling 2018-08-29T14:33:18.4607305 v2 42934 2018-08-02 Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour. 93d93d70ee3b4cc4538f4319cded2356 NULL Aled Huws Bryant Aled Huws Bryant true true 2018-08-02 SummaryInterest in the innate immune response at the maternal-fetal interface has developeddue to the association between intrauterine infection, inflammation and adversepregnancy outcomes. Pattern recognition receptors (PRRs) offer a link betweenmicrobial derived agonists and the production of inflammatory mediators bygestation-associated tissues (placenta, choriodecidua and amnion). An improvedunderstanding of these receptors and the signal transduction cascades they initiatein these tissues might explain why some pregnancies are complicated by pretermlabour (PTL) and preterm premature rupture of the membranes (PPROM) whereasothers are only affected by PPROM. However while this may be the eventual aim ofthis field of study; a greater understanding of PRR expression and activity in termnon-laboured tissues is required to provide a baseline comparison for thesereceptors, in order to determine any potential role they may play in normal termlabour but also in preterm labour and other adverse pregnancy outcomes.Examination of PRRs in term non-laboured gestation-associated tissuesdemonstrated the expression of transcripts for Toll-like Receptors (TLRs), NOD-likereceptors (NLRs), RIG-l-like Receptors (RLRs) and C-type lectin Receptors (CLRs).A functional role for TLRs 1-7, NOD1, NOD2, RIG-I/MDA5 and Dectin-1 can beinferred by an increase in the production of IL-6 and IL-8 following stimulation withreceptor specific agonists. IL-1p production and activation of the caspase-1 and/orcaspase-8 inflammasome was observed in the placenta and choriodecidua inresponse to fungal (3-glucan and bacterial flagellin. The anti-inflammatory cytokinesIL-4, IL-10 and IL-13 are able to down-regulate the lipopolysaccharide-stimulatedcytokine responses by the placenta, choriodecidua and amnion. This highlights thepotential utility of these cytokines in preventing preterm birth. E-Thesis Innate immunity 31 12 2014 2014-12-31 COLLEGE NANME Swansea University Medical School COLLEGE CODE Swansea University Doctoral Ph.D 2018-08-29T14:33:18.4607305 2018-08-02T16:24:30.8198052 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Aled Huws Bryant NULL 1 0042934-02082018162533.pdf 10821324.pdf 2018-08-02T16:25:33.3930000 Output 14167747 application/pdf E-Thesis true 2018-08-02T16:25:33.3930000 false
title Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour.
spellingShingle Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour.
Aled Huws Bryant
title_short Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour.
title_full Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour.
title_fullStr Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour.
title_full_unstemmed Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour.
title_sort Pattern recognition receptor activity at the maternal fetal interface: Implications for preterm labour.
author_id_str_mv 93d93d70ee3b4cc4538f4319cded2356
author_id_fullname_str_mv 93d93d70ee3b4cc4538f4319cded2356_***_Aled Huws Bryant
author Aled Huws Bryant
author2 Aled Huws Bryant
format E-Thesis
publishDate 2014
institution Swansea University
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description SummaryInterest in the innate immune response at the maternal-fetal interface has developeddue to the association between intrauterine infection, inflammation and adversepregnancy outcomes. Pattern recognition receptors (PRRs) offer a link betweenmicrobial derived agonists and the production of inflammatory mediators bygestation-associated tissues (placenta, choriodecidua and amnion). An improvedunderstanding of these receptors and the signal transduction cascades they initiatein these tissues might explain why some pregnancies are complicated by pretermlabour (PTL) and preterm premature rupture of the membranes (PPROM) whereasothers are only affected by PPROM. However while this may be the eventual aim ofthis field of study; a greater understanding of PRR expression and activity in termnon-laboured tissues is required to provide a baseline comparison for thesereceptors, in order to determine any potential role they may play in normal termlabour but also in preterm labour and other adverse pregnancy outcomes.Examination of PRRs in term non-laboured gestation-associated tissuesdemonstrated the expression of transcripts for Toll-like Receptors (TLRs), NOD-likereceptors (NLRs), RIG-l-like Receptors (RLRs) and C-type lectin Receptors (CLRs).A functional role for TLRs 1-7, NOD1, NOD2, RIG-I/MDA5 and Dectin-1 can beinferred by an increase in the production of IL-6 and IL-8 following stimulation withreceptor specific agonists. IL-1p production and activation of the caspase-1 and/orcaspase-8 inflammasome was observed in the placenta and choriodecidua inresponse to fungal (3-glucan and bacterial flagellin. The anti-inflammatory cytokinesIL-4, IL-10 and IL-13 are able to down-regulate the lipopolysaccharide-stimulatedcytokine responses by the placenta, choriodecidua and amnion. This highlights thepotential utility of these cytokines in preventing preterm birth.
published_date 2014-12-31T03:53:56Z
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score 10.999252

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