Lung cancer: a new frontier for microbiome research and clinical translation

Mur, Luis AJ; Huws, Sharon A; Cameron, Simon JS; Lewis, Paul; Lewis, Keir E

doi:10.3332/ecancer.2018.866

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Lung cancer: a new frontier for microbiome research and clinical translation

Luis AJ Mur, Sharon A Huws, Simon JS Cameron, Paul Lewis, Keir E Lewis

ecancermedicalscience, Volume: 12

Swansea University Author: Paul Lewis

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DOI (Published version): 10.3332/ecancer.2018.866

Abstract

The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights...

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Published in:	ecancermedicalscience
ISSN:	17546605
Published:	2018
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa45296
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first_indexed	2018-10-30T20:30:51Z
last_indexed	2018-12-03T14:25:28Z
id	cronfa45296
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spelling	2018-12-03T12:49:10.3699943 v2 45296 2018-10-30 Lung cancer: a new frontier for microbiome research and clinical translation 46dfc22d7468f247c390ba0c6cd8fba6 Paul Lewis Paul Lewis true false 2018-10-30 SGMGT The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome. Journal Article ecancermedicalscience 12 17546605 lung cancer, microbiome, Granulicatella, ATP 5 9 2018 2018-09-05 10.3332/ecancer.2018.866 https://ecancer.org/journal/12/full/866-lung-cancer-a-new-frontier-for-microbiome-research-and-clinical-translation.php COLLEGE NANME School of Management - School COLLEGE CODE SGMGT Swansea University 2018-12-03T12:49:10.3699943 2018-10-30T13:04:40.0177707 Faculty of Humanities and Social Sciences School of Management - Business Management Luis AJ Mur 1 Sharon A Huws 2 Simon JS Cameron 3 Paul Lewis 4 Keir E Lewis 5 0045296-09112018163408.pdf 45296.pdf 2018-11-09T16:34:08.9370000 Output 589002 application/pdf Accepted Manuscript true 2018-11-08T00:00:00.0000000 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng
title	Lung cancer: a new frontier for microbiome research and clinical translation
spellingShingle	Lung cancer: a new frontier for microbiome research and clinical translation Paul Lewis
title_short	Lung cancer: a new frontier for microbiome research and clinical translation
title_full	Lung cancer: a new frontier for microbiome research and clinical translation
title_fullStr	Lung cancer: a new frontier for microbiome research and clinical translation
title_full_unstemmed	Lung cancer: a new frontier for microbiome research and clinical translation
title_sort	Lung cancer: a new frontier for microbiome research and clinical translation
author_id_str_mv	46dfc22d7468f247c390ba0c6cd8fba6
author_id_fullname_str_mv	46dfc22d7468f247c390ba0c6cd8fba6_***_Paul Lewis
author	Paul Lewis
author2	Luis AJ Mur Sharon A Huws Simon JS Cameron Paul Lewis Keir E Lewis
format	Journal article
container_title	ecancermedicalscience
container_volume	12
publishDate	2018
institution	Swansea University
issn	17546605
doi_str_mv	10.3332/ecancer.2018.866
college_str	Faculty of Humanities and Social Sciences
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hierarchy_top_id	facultyofhumanitiesandsocialsciences
hierarchy_top_title	Faculty of Humanities and Social Sciences
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department_str	School of Management - Business Management{{{_:::_}}}Faculty of Humanities and Social Sciences{{{_:::_}}}School of Management - Business Management
url	https://ecancer.org/journal/12/full/866-lung-cancer-a-new-frontier-for-microbiome-research-and-clinical-translation.php
document_store_str	1
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description	The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome.
published_date	2018-09-05T03:57:02Z
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score	11.021648

Lung cancer: a new frontier for microbiome research and clinical translation

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