Journal article 891 views 85 downloads
Lung cancer: a new frontier for microbiome research and clinical translation
Luis AJ Mur,
Sharon A Huws,
Simon JS Cameron,
Paul Lewis,
Keir E Lewis
ecancermedicalscience, Volume: 12
Swansea University Author: Paul Lewis
-
PDF | Accepted Manuscript
Released under the terms of a Creative Commons Attribution License (CC-BY).
Download (545.69KB)
DOI (Published version): 10.3332/ecancer.2018.866
Abstract
The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights...
Published in: | ecancermedicalscience |
---|---|
ISSN: | 17546605 |
Published: |
2018
|
Online Access: |
Check full text
|
URI: | https://cronfa.swan.ac.uk/Record/cronfa45296 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
first_indexed |
2018-10-30T20:30:51Z |
---|---|
last_indexed |
2018-12-03T14:25:28Z |
id |
cronfa45296 |
recordtype |
SURis |
fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2018-12-03T12:49:10.3699943</datestamp><bib-version>v2</bib-version><id>45296</id><entry>2018-10-30</entry><title>Lung cancer: a new frontier for microbiome research and clinical translation</title><swanseaauthors><author><sid>46dfc22d7468f247c390ba0c6cd8fba6</sid><firstname>Paul</firstname><surname>Lewis</surname><name>Paul Lewis</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-10-30</date><deptcode>SGMGT</deptcode><abstract>The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome.</abstract><type>Journal Article</type><journal>ecancermedicalscience</journal><volume>12</volume><publisher/><issnElectronic>17546605</issnElectronic><keywords>lung cancer, microbiome, Granulicatella, ATP</keywords><publishedDay>5</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-09-05</publishedDate><doi>10.3332/ecancer.2018.866</doi><url>https://ecancer.org/journal/12/full/866-lung-cancer-a-new-frontier-for-microbiome-research-and-clinical-translation.php</url><notes/><college>COLLEGE NANME</college><department>School of Management - School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>SGMGT</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2018-12-03T12:49:10.3699943</lastEdited><Created>2018-10-30T13:04:40.0177707</Created><path><level id="1">Faculty of Humanities and Social Sciences</level><level id="2">School of Management - Business Management</level></path><authors><author><firstname>Luis AJ</firstname><surname>Mur</surname><order>1</order></author><author><firstname>Sharon A</firstname><surname>Huws</surname><order>2</order></author><author><firstname>Simon JS</firstname><surname>Cameron</surname><order>3</order></author><author><firstname>Paul</firstname><surname>Lewis</surname><order>4</order></author><author><firstname>Keir E</firstname><surname>Lewis</surname><order>5</order></author></authors><documents><document><filename>0045296-09112018163408.pdf</filename><originalFilename>45296.pdf</originalFilename><uploaded>2018-11-09T16:34:08.9370000</uploaded><type>Output</type><contentLength>589002</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2018-11-08T00:00:00.0000000</embargoDate><documentNotes>Released under the terms of a Creative Commons Attribution License (CC-BY).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807> |
spelling |
2018-12-03T12:49:10.3699943 v2 45296 2018-10-30 Lung cancer: a new frontier for microbiome research and clinical translation 46dfc22d7468f247c390ba0c6cd8fba6 Paul Lewis Paul Lewis true false 2018-10-30 SGMGT The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome. Journal Article ecancermedicalscience 12 17546605 lung cancer, microbiome, Granulicatella, ATP 5 9 2018 2018-09-05 10.3332/ecancer.2018.866 https://ecancer.org/journal/12/full/866-lung-cancer-a-new-frontier-for-microbiome-research-and-clinical-translation.php COLLEGE NANME School of Management - School COLLEGE CODE SGMGT Swansea University 2018-12-03T12:49:10.3699943 2018-10-30T13:04:40.0177707 Faculty of Humanities and Social Sciences School of Management - Business Management Luis AJ Mur 1 Sharon A Huws 2 Simon JS Cameron 3 Paul Lewis 4 Keir E Lewis 5 0045296-09112018163408.pdf 45296.pdf 2018-11-09T16:34:08.9370000 Output 589002 application/pdf Accepted Manuscript true 2018-11-08T00:00:00.0000000 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng |
title |
Lung cancer: a new frontier for microbiome research and clinical translation |
spellingShingle |
Lung cancer: a new frontier for microbiome research and clinical translation Paul Lewis |
title_short |
Lung cancer: a new frontier for microbiome research and clinical translation |
title_full |
Lung cancer: a new frontier for microbiome research and clinical translation |
title_fullStr |
Lung cancer: a new frontier for microbiome research and clinical translation |
title_full_unstemmed |
Lung cancer: a new frontier for microbiome research and clinical translation |
title_sort |
Lung cancer: a new frontier for microbiome research and clinical translation |
author_id_str_mv |
46dfc22d7468f247c390ba0c6cd8fba6 |
author_id_fullname_str_mv |
46dfc22d7468f247c390ba0c6cd8fba6_***_Paul Lewis |
author |
Paul Lewis |
author2 |
Luis AJ Mur Sharon A Huws Simon JS Cameron Paul Lewis Keir E Lewis |
format |
Journal article |
container_title |
ecancermedicalscience |
container_volume |
12 |
publishDate |
2018 |
institution |
Swansea University |
issn |
17546605 |
doi_str_mv |
10.3332/ecancer.2018.866 |
college_str |
Faculty of Humanities and Social Sciences |
hierarchytype |
|
hierarchy_top_id |
facultyofhumanitiesandsocialsciences |
hierarchy_top_title |
Faculty of Humanities and Social Sciences |
hierarchy_parent_id |
facultyofhumanitiesandsocialsciences |
hierarchy_parent_title |
Faculty of Humanities and Social Sciences |
department_str |
School of Management - Business Management{{{_:::_}}}Faculty of Humanities and Social Sciences{{{_:::_}}}School of Management - Business Management |
url |
https://ecancer.org/journal/12/full/866-lung-cancer-a-new-frontier-for-microbiome-research-and-clinical-translation.php |
document_store_str |
1 |
active_str |
0 |
description |
The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome. |
published_date |
2018-09-05T03:57:02Z |
_version_ |
1763752880743907328 |
score |
11.021648 |