No Cover Image

Journal article 1362 views 154 downloads

Lung cancer: a new frontier for microbiome research and clinical translation

Luis AJ Mur, Sharon A Huws, Simon JS Cameron, Paul Lewis, Keir E Lewis

ecancermedicalscience, Volume: 12

Swansea University Author: Paul Lewis

  • 45296.pdf

    PDF | Accepted Manuscript

    Released under the terms of a Creative Commons Attribution License (CC-BY).

    Download (545.69KB)

Check full text

DOI (Published version): 10.3332/ecancer.2018.866

Abstract

The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights...

Full description

Published in: ecancermedicalscience
ISSN: 17546605
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa45296
first_indexed 2018-10-30T20:30:51Z
last_indexed 2018-12-03T14:25:28Z
id cronfa45296
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2018-12-03T12:49:10.3699943</datestamp><bib-version>v2</bib-version><id>45296</id><entry>2018-10-30</entry><title>Lung cancer: a new frontier for microbiome research and clinical translation</title><swanseaauthors><author><sid>46dfc22d7468f247c390ba0c6cd8fba6</sid><firstname>Paul</firstname><surname>Lewis</surname><name>Paul Lewis</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-10-30</date><deptcode>CBAE</deptcode><abstract>The lung microbiome has been shown to reflect a range of pulmonary diseases&#x2014;for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome.</abstract><type>Journal Article</type><journal>ecancermedicalscience</journal><volume>12</volume><publisher/><issnElectronic>17546605</issnElectronic><keywords>lung cancer, microbiome, Granulicatella, ATP</keywords><publishedDay>5</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-09-05</publishedDate><doi>10.3332/ecancer.2018.866</doi><url>https://ecancer.org/journal/12/full/866-lung-cancer-a-new-frontier-for-microbiome-research-and-clinical-translation.php</url><notes/><college>COLLEGE NANME</college><department>Management School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>CBAE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2018-12-03T12:49:10.3699943</lastEdited><Created>2018-10-30T13:04:40.0177707</Created><path><level id="1">Faculty of Humanities and Social Sciences</level><level id="2">School of Management - Business Management</level></path><authors><author><firstname>Luis AJ</firstname><surname>Mur</surname><order>1</order></author><author><firstname>Sharon A</firstname><surname>Huws</surname><order>2</order></author><author><firstname>Simon JS</firstname><surname>Cameron</surname><order>3</order></author><author><firstname>Paul</firstname><surname>Lewis</surname><order>4</order></author><author><firstname>Keir E</firstname><surname>Lewis</surname><order>5</order></author></authors><documents><document><filename>0045296-09112018163408.pdf</filename><originalFilename>45296.pdf</originalFilename><uploaded>2018-11-09T16:34:08.9370000</uploaded><type>Output</type><contentLength>589002</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2018-11-08T00:00:00.0000000</embargoDate><documentNotes>Released under the terms of a Creative Commons Attribution License (CC-BY).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2018-12-03T12:49:10.3699943 v2 45296 2018-10-30 Lung cancer: a new frontier for microbiome research and clinical translation 46dfc22d7468f247c390ba0c6cd8fba6 Paul Lewis Paul Lewis true false 2018-10-30 CBAE The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome. Journal Article ecancermedicalscience 12 17546605 lung cancer, microbiome, Granulicatella, ATP 5 9 2018 2018-09-05 10.3332/ecancer.2018.866 https://ecancer.org/journal/12/full/866-lung-cancer-a-new-frontier-for-microbiome-research-and-clinical-translation.php COLLEGE NANME Management School COLLEGE CODE CBAE Swansea University 2018-12-03T12:49:10.3699943 2018-10-30T13:04:40.0177707 Faculty of Humanities and Social Sciences School of Management - Business Management Luis AJ Mur 1 Sharon A Huws 2 Simon JS Cameron 3 Paul Lewis 4 Keir E Lewis 5 0045296-09112018163408.pdf 45296.pdf 2018-11-09T16:34:08.9370000 Output 589002 application/pdf Accepted Manuscript true 2018-11-08T00:00:00.0000000 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng
title Lung cancer: a new frontier for microbiome research and clinical translation
spellingShingle Lung cancer: a new frontier for microbiome research and clinical translation
Paul Lewis
title_short Lung cancer: a new frontier for microbiome research and clinical translation
title_full Lung cancer: a new frontier for microbiome research and clinical translation
title_fullStr Lung cancer: a new frontier for microbiome research and clinical translation
title_full_unstemmed Lung cancer: a new frontier for microbiome research and clinical translation
title_sort Lung cancer: a new frontier for microbiome research and clinical translation
author_id_str_mv 46dfc22d7468f247c390ba0c6cd8fba6
author_id_fullname_str_mv 46dfc22d7468f247c390ba0c6cd8fba6_***_Paul Lewis
author Paul Lewis
author2 Luis AJ Mur
Sharon A Huws
Simon JS Cameron
Paul Lewis
Keir E Lewis
format Journal article
container_title ecancermedicalscience
container_volume 12
publishDate 2018
institution Swansea University
issn 17546605
doi_str_mv 10.3332/ecancer.2018.866
college_str Faculty of Humanities and Social Sciences
hierarchytype
hierarchy_top_id facultyofhumanitiesandsocialsciences
hierarchy_top_title Faculty of Humanities and Social Sciences
hierarchy_parent_id facultyofhumanitiesandsocialsciences
hierarchy_parent_title Faculty of Humanities and Social Sciences
department_str School of Management - Business Management{{{_:::_}}}Faculty of Humanities and Social Sciences{{{_:::_}}}School of Management - Business Management
url https://ecancer.org/journal/12/full/866-lung-cancer-a-new-frontier-for-microbiome-research-and-clinical-translation.php
document_store_str 1
active_str 0
description The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome.
published_date 2018-09-05T04:30:05Z
_version_ 1859429131332091904
score 11.099897

Similar Items