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Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use / Catherine, Thornton

The International Journal of Artificial Organs, Start page: 039139881881732

Swansea University Author: Catherine, Thornton

Abstract

Heart failure (HF) remains a disease of ever increasing prevalence in the modern world. Patients with end-stage HF are being referred increasingly for mechanical circulatory support (MCS). MCS can assist patients who are ineligible for transplant and stabilise eligible patients prior to transplantat...

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Published in: The International Journal of Artificial Organs
ISSN: 0391-3988 1724-6040
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa45953
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first_indexed 2018-11-16T20:18:30Z
last_indexed 2019-01-21T14:00:29Z
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spelling 2019-01-21T11:55:30.4469878 v2 45953 2018-11-16 Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Catherine Thornton Catherine Thornton true false 2018-11-16 BMS Heart failure (HF) remains a disease of ever increasing prevalence in the modern world. Patients with end-stage HF are being referred increasingly for mechanical circulatory support (MCS). MCS can assist patients who are ineligible for transplant and stabilise eligible patients prior to transplantation. It is also used during cardiopulmonary bypass (CPB) surgery to maintain circulation whilst operating on the heart. Whilst MCS can stabilise HF and improve quality of life, complications such as infection and thrombosis remain a common risk. Leukocytes can contribute to both of these complications. Contact with foreign surfaces and the introduction of artificial mechanical shear stress can lead to activation of leukocytes, reduced functionality, and the release of pro-inflammatory and pro-thrombogenic microparticles. Assessing the impact of mechanical trauma to leukocytes is largely overlooked in comparison to red blood cells and platelets. This review provides an overview of the available literature on the effects of in vitro to clinical MCS systems on leukocyte phenotype and function. One purpose of this review is to emphasise the importance of studying mechanical trauma to leukocytes to better understand the occurrence of adverse events during MCS. Journal Article The International Journal of Artificial Organs 039139881881732 0391-3988 1724-6040 Flow cytometry; leukocytes; shear stress; ventricular assist devices 1 1 2018 2018-01-01 10.1177/0391398818817326 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2019-01-21T11:55:30.4469878 2018-11-16T13:29:56.1097133 Swansea University Medical School Medicine Gemma Radley 1 Sabrina Ali 2 Ina Laura Pieper 3 Catherine Thornton 0000-0002-5153-573X 4 0045953-16112018133331.pdf Thornton_IJAO_review.pdf 2018-11-16T13:33:31.1400000 Output 436599 application/pdf Accepted Manuscript true 2018-12-26T00:00:00.0000000 true eng
title Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use
spellingShingle Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use
Catherine, Thornton
title_short Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use
title_full Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use
title_fullStr Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use
title_full_unstemmed Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use
title_sort Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use
author_id_str_mv c71a7a4be7361094d046d312202bce0c
author_id_fullname_str_mv c71a7a4be7361094d046d312202bce0c_***_Catherine, Thornton
author Catherine, Thornton
format Journal article
container_title The International Journal of Artificial Organs
container_start_page 039139881881732
publishDate 2018
institution Swansea University
issn 0391-3988
1724-6040
doi_str_mv 10.1177/0391398818817326
college_str Swansea University Medical School
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hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
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description Heart failure (HF) remains a disease of ever increasing prevalence in the modern world. Patients with end-stage HF are being referred increasingly for mechanical circulatory support (MCS). MCS can assist patients who are ineligible for transplant and stabilise eligible patients prior to transplantation. It is also used during cardiopulmonary bypass (CPB) surgery to maintain circulation whilst operating on the heart. Whilst MCS can stabilise HF and improve quality of life, complications such as infection and thrombosis remain a common risk. Leukocytes can contribute to both of these complications. Contact with foreign surfaces and the introduction of artificial mechanical shear stress can lead to activation of leukocytes, reduced functionality, and the release of pro-inflammatory and pro-thrombogenic microparticles. Assessing the impact of mechanical trauma to leukocytes is largely overlooked in comparison to red blood cells and platelets. This review provides an overview of the available literature on the effects of in vitro to clinical MCS systems on leukocyte phenotype and function. One purpose of this review is to emphasise the importance of studying mechanical trauma to leukocytes to better understand the occurrence of adverse events during MCS.
published_date 2018-01-01T19:05:51Z
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