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Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes / Rachel, Churm; Jeffrey, Davies; Sarah, Prior

Molecular and Cellular Endocrinology, Volume: 481, Pages: 8 - 13

Swansea University Authors: Rachel, Churm, Jeffrey, Davies, Sarah, Prior

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Abstract

Acyl-ghrelin has various peripheral effects including the potential role in mediating cellular lipid removal and macrophage polarization. Previous reports are contradictory as to how glycaemia and acyl-ghrelin mediates lipid retention and inflammation within individuals with Type 2 diabetes (T2D). O...

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Published in: Molecular and Cellular Endocrinology
ISSN: 0303-7207
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa45975
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first_indexed 2018-11-19T14:28:29Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2020-07-20T12:44:49.5037878</datestamp><bib-version>v2</bib-version><id>45975</id><entry>2018-11-19</entry><title>Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes</title><swanseaauthors><author><sid>c6cd8267ff0b13f2ea333bbfefdae144</sid><ORCID>0000-0001-9855-6282</ORCID><firstname>Rachel</firstname><surname>Churm</surname><name>Rachel Churm</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>2cb3d1d96a7870a84d2f758e865172e6</sid><ORCID>0000-0002-4234-0033</ORCID><firstname>Jeffrey</firstname><surname>Davies</surname><name>Jeffrey Davies</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>cdda101035997acfaa6fdf17097f52b2</sid><ORCID>0000-0001-8703-8092</ORCID><firstname>Sarah</firstname><surname>Prior</surname><name>Sarah Prior</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-11-19</date><deptcode>STSC</deptcode><abstract>Acyl-ghrelin has various peripheral effects including the potential role in mediating cellular lipid removal and macrophage polarization. Previous reports are contradictory as to how glycaemia and acyl-ghrelin mediates lipid retention and inflammation within individuals with Type 2 diabetes (T2D). Our aim was to explore acyl-ghrelin levels and ghrelin expression in relation to lipid and inflammatory markers within an ex vivo human model, biopsied visceral adipose tissue.Results indicated that acyl-ghrelin was associated with a decline in key lipid homeostasis genes ABCG1 and LXR&#x3B2; expression. Within T2D there was also a down regulation of these genes which was independent of acyl-ghrelin levels. Circulatory pro-inflammatory markers (IL-6 and TNF&#x3B1;) had no association with ghrelin expression nor circulating acyl-ghrelin levels. Anti-inflammatory marker (IL-10) and total antioxidant status (TAOS%) were positively associated with ghrelin expression across samples from all groups combined (total sample cohort) and specifically within the obesity sample cohorts.Data supported the hypothesis that hyperglycaemia and acyl-ghrelin have a regulatory role in lipid retention. Furthermore, that both acyl- and desacyl-ghrelin is responsible for a protective inflammatory response; however this response is diminished in T2D.</abstract><type>Journal Article</type><journal>Molecular and Cellular Endocrinology</journal><volume>481</volume><paginationStart>8</paginationStart><paginationEnd>13</paginationEnd><publisher/><issnPrint>0303-7207</issnPrint><keywords/><publishedDay>5</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-02-05</publishedDate><doi>10.1016/j.mce.2018.11.004</doi><url/><notes/><college>COLLEGE NANME</college><department>Sports Science</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><lastEdited>2020-07-20T12:44:49.5037878</lastEdited><Created>2018-11-19T12:03:48.8766833</Created><authors><author><firstname>Rachel</firstname><surname>Churm</surname><orcid>0000-0001-9855-6282</orcid><order>1</order></author><author><firstname>S.</firstname><surname>Caplin</surname><order>2</order></author><author><firstname>J.</firstname><surname>Barry</surname><order>3</order></author><author><firstname>Jeffrey</firstname><surname>Davies</surname><orcid>0000-0002-4234-0033</orcid><order>4</order></author><author><firstname>J.W.</firstname><surname>Stephens</surname><order>5</order></author><author><firstname>Sarah</firstname><surname>Prior</surname><orcid>0000-0001-8703-8092</orcid><order>6</order></author></authors><documents><document><filename>0045975-19112018120648.pdf</filename><originalFilename>Churm2018.pdf</originalFilename><uploaded>2018-11-19T12:06:48.8270000</uploaded><type>Output</type><contentLength>922216</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><action/><embargoDate>2019-11-13T00:00:00.0000000</embargoDate><documentNotes>Released under the terms of a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2020-07-20T12:44:49.5037878 v2 45975 2018-11-19 Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes c6cd8267ff0b13f2ea333bbfefdae144 0000-0001-9855-6282 Rachel Churm Rachel Churm true false 2cb3d1d96a7870a84d2f758e865172e6 0000-0002-4234-0033 Jeffrey Davies Jeffrey Davies true false cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false 2018-11-19 STSC Acyl-ghrelin has various peripheral effects including the potential role in mediating cellular lipid removal and macrophage polarization. Previous reports are contradictory as to how glycaemia and acyl-ghrelin mediates lipid retention and inflammation within individuals with Type 2 diabetes (T2D). Our aim was to explore acyl-ghrelin levels and ghrelin expression in relation to lipid and inflammatory markers within an ex vivo human model, biopsied visceral adipose tissue.Results indicated that acyl-ghrelin was associated with a decline in key lipid homeostasis genes ABCG1 and LXRβ expression. Within T2D there was also a down regulation of these genes which was independent of acyl-ghrelin levels. Circulatory pro-inflammatory markers (IL-6 and TNFα) had no association with ghrelin expression nor circulating acyl-ghrelin levels. Anti-inflammatory marker (IL-10) and total antioxidant status (TAOS%) were positively associated with ghrelin expression across samples from all groups combined (total sample cohort) and specifically within the obesity sample cohorts.Data supported the hypothesis that hyperglycaemia and acyl-ghrelin have a regulatory role in lipid retention. Furthermore, that both acyl- and desacyl-ghrelin is responsible for a protective inflammatory response; however this response is diminished in T2D. Journal Article Molecular and Cellular Endocrinology 481 8 13 0303-7207 5 2 2019 2019-02-05 10.1016/j.mce.2018.11.004 COLLEGE NANME Sports Science COLLEGE CODE STSC Swansea University 2020-07-20T12:44:49.5037878 2018-11-19T12:03:48.8766833 Rachel Churm 0000-0001-9855-6282 1 S. Caplin 2 J. Barry 3 Jeffrey Davies 0000-0002-4234-0033 4 J.W. Stephens 5 Sarah Prior 0000-0001-8703-8092 6 0045975-19112018120648.pdf Churm2018.pdf 2018-11-19T12:06:48.8270000 Output 922216 application/pdf Accepted Manuscript true 2019-11-13T00:00:00.0000000 Released under the terms of a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND). true eng
title Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes
spellingShingle Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes
Rachel, Churm
Jeffrey, Davies
Sarah, Prior
title_short Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes
title_full Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes
title_fullStr Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes
title_full_unstemmed Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes
title_sort Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes
author_id_str_mv c6cd8267ff0b13f2ea333bbfefdae144
2cb3d1d96a7870a84d2f758e865172e6
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author_id_fullname_str_mv c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel, Churm
2cb3d1d96a7870a84d2f758e865172e6_***_Jeffrey, Davies
cdda101035997acfaa6fdf17097f52b2_***_Sarah, Prior
author Rachel, Churm
Jeffrey, Davies
Sarah, Prior
format Journal article
container_title Molecular and Cellular Endocrinology
container_volume 481
container_start_page 8
publishDate 2019
institution Swansea University
issn 0303-7207
doi_str_mv 10.1016/j.mce.2018.11.004
document_store_str 1
active_str 0
description Acyl-ghrelin has various peripheral effects including the potential role in mediating cellular lipid removal and macrophage polarization. Previous reports are contradictory as to how glycaemia and acyl-ghrelin mediates lipid retention and inflammation within individuals with Type 2 diabetes (T2D). Our aim was to explore acyl-ghrelin levels and ghrelin expression in relation to lipid and inflammatory markers within an ex vivo human model, biopsied visceral adipose tissue.Results indicated that acyl-ghrelin was associated with a decline in key lipid homeostasis genes ABCG1 and LXRβ expression. Within T2D there was also a down regulation of these genes which was independent of acyl-ghrelin levels. Circulatory pro-inflammatory markers (IL-6 and TNFα) had no association with ghrelin expression nor circulating acyl-ghrelin levels. Anti-inflammatory marker (IL-10) and total antioxidant status (TAOS%) were positively associated with ghrelin expression across samples from all groups combined (total sample cohort) and specifically within the obesity sample cohorts.Data supported the hypothesis that hyperglycaemia and acyl-ghrelin have a regulatory role in lipid retention. Furthermore, that both acyl- and desacyl-ghrelin is responsible for a protective inflammatory response; however this response is diminished in T2D.
published_date 2019-02-05T04:11:09Z
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