Journal article 882 views 146 downloads
Electromechanical vibration of microtubules and its application in biosensors
Journal of The Royal Society Interface, Volume: 16, Issue: 151, Start page: 20180826
Swansea University Authors:
Chengyuan Wang , Perumal Nithiarasu
-
PDF | Accepted Manuscript
Download (1.86MB)
DOI (Published version): 10.1098/rsif.2018.0826
Abstract
An electric field (EF) has the potential to excite the vibration of polarized microtubules (MTs) and thus enable their use as a biosensor for the biophysical properties of MTs or cells. To facilitate the development, this paper aims to capture the EF-induced vibration modes and the associated freque...
Published in: | Journal of The Royal Society Interface |
---|---|
ISSN: | 1742-5689 1742-5662 |
Published: |
2019
|
Online Access: |
Check full text
|
URI: | https://cronfa.swan.ac.uk/Record/cronfa48679 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
first_indexed |
2019-02-04T20:02:38Z |
---|---|
last_indexed |
2019-03-26T12:21:57Z |
id |
cronfa48679 |
recordtype |
SURis |
fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2019-03-25T16:42:39.5103791</datestamp><bib-version>v2</bib-version><id>48679</id><entry>2019-02-04</entry><title>Electromechanical vibration of microtubules and its application in biosensors</title><swanseaauthors><author><sid>fdea93ab99f51d0b3921d3601876c1e5</sid><ORCID>0000-0002-1001-2537</ORCID><firstname>Chengyuan</firstname><surname>Wang</surname><name>Chengyuan Wang</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>3b28bf59358fc2b9bd9a46897dbfc92d</sid><ORCID>0000-0002-4901-2980</ORCID><firstname>Perumal</firstname><surname>Nithiarasu</surname><name>Perumal Nithiarasu</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-02-04</date><deptcode>MECH</deptcode><abstract>An electric field (EF) has the potential to excite the vibration of polarized microtubules (MTs) and thus enable their use as a biosensor for the biophysical properties of MTs or cells. To facilitate the development, this paper aims to capture the EF-induced vibration modes and the associated frequency for MTs. The analyses were carried out based on a molecular structural mechanics model accounting for the structural details of MTs. Transverse vibration, radial breathing vibration and axial vibration were achieved for MTs subject to a transverse or an axial EF. The frequency shift and stiffness alteration of MTs were also examined due to the possible changes of the tubulin interactions in physiological or pathological processes. The strong correlation achieved between the tubulin interaction and MT vibration excited by EF provides a new avenue to a non-contacting technique for the structural or property changes in MTs, where frequency shift is used as a biomarker. This technique can be used for individual MTs and is possible for those in cells when the cytosol damping on MT vibrations is largely reduced by the unique features of MT–cytosol interface.</abstract><type>Journal Article</type><journal>Journal of The Royal Society Interface</journal><volume>16</volume><journalNumber>151</journalNumber><paginationStart>20180826</paginationStart><publisher/><issnPrint>1742-5689</issnPrint><issnElectronic>1742-5662</issnElectronic><keywords/><publishedDay>28</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-02-28</publishedDate><doi>10.1098/rsif.2018.0826</doi><url/><notes/><college>COLLEGE NANME</college><department>Mechanical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MECH</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-03-25T16:42:39.5103791</lastEdited><Created>2019-02-04T13:42:51.9116045</Created><authors><author><firstname>Si</firstname><surname>Li</surname><order>1</order></author><author><firstname>Chengyuan</firstname><surname>Wang</surname><orcid>0000-0002-1001-2537</orcid><order>2</order></author><author><firstname>Perumal</firstname><surname>Nithiarasu</surname><orcid>0000-0002-4901-2980</orcid><order>3</order></author></authors><documents><document><filename>0048679-04022019134516.pdf</filename><originalFilename>li2019(3).pdf</originalFilename><uploaded>2019-02-04T13:45:16.3630000</uploaded><type>Output</type><contentLength>1963135</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-02-12T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807> |
spelling |
2019-03-25T16:42:39.5103791 v2 48679 2019-02-04 Electromechanical vibration of microtubules and its application in biosensors fdea93ab99f51d0b3921d3601876c1e5 0000-0002-1001-2537 Chengyuan Wang Chengyuan Wang true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2019-02-04 MECH An electric field (EF) has the potential to excite the vibration of polarized microtubules (MTs) and thus enable their use as a biosensor for the biophysical properties of MTs or cells. To facilitate the development, this paper aims to capture the EF-induced vibration modes and the associated frequency for MTs. The analyses were carried out based on a molecular structural mechanics model accounting for the structural details of MTs. Transverse vibration, radial breathing vibration and axial vibration were achieved for MTs subject to a transverse or an axial EF. The frequency shift and stiffness alteration of MTs were also examined due to the possible changes of the tubulin interactions in physiological or pathological processes. The strong correlation achieved between the tubulin interaction and MT vibration excited by EF provides a new avenue to a non-contacting technique for the structural or property changes in MTs, where frequency shift is used as a biomarker. This technique can be used for individual MTs and is possible for those in cells when the cytosol damping on MT vibrations is largely reduced by the unique features of MT–cytosol interface. Journal Article Journal of The Royal Society Interface 16 151 20180826 1742-5689 1742-5662 28 2 2019 2019-02-28 10.1098/rsif.2018.0826 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2019-03-25T16:42:39.5103791 2019-02-04T13:42:51.9116045 Si Li 1 Chengyuan Wang 0000-0002-1001-2537 2 Perumal Nithiarasu 0000-0002-4901-2980 3 0048679-04022019134516.pdf li2019(3).pdf 2019-02-04T13:45:16.3630000 Output 1963135 application/pdf Accepted Manuscript true 2019-02-12T00:00:00.0000000 true eng |
title |
Electromechanical vibration of microtubules and its application in biosensors |
spellingShingle |
Electromechanical vibration of microtubules and its application in biosensors Chengyuan Wang Perumal Nithiarasu |
title_short |
Electromechanical vibration of microtubules and its application in biosensors |
title_full |
Electromechanical vibration of microtubules and its application in biosensors |
title_fullStr |
Electromechanical vibration of microtubules and its application in biosensors |
title_full_unstemmed |
Electromechanical vibration of microtubules and its application in biosensors |
title_sort |
Electromechanical vibration of microtubules and its application in biosensors |
author_id_str_mv |
fdea93ab99f51d0b3921d3601876c1e5 3b28bf59358fc2b9bd9a46897dbfc92d |
author_id_fullname_str_mv |
fdea93ab99f51d0b3921d3601876c1e5_***_Chengyuan Wang 3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu |
author |
Chengyuan Wang Perumal Nithiarasu |
author2 |
Si Li Chengyuan Wang Perumal Nithiarasu |
format |
Journal article |
container_title |
Journal of The Royal Society Interface |
container_volume |
16 |
container_issue |
151 |
container_start_page |
20180826 |
publishDate |
2019 |
institution |
Swansea University |
issn |
1742-5689 1742-5662 |
doi_str_mv |
10.1098/rsif.2018.0826 |
document_store_str |
1 |
active_str |
0 |
description |
An electric field (EF) has the potential to excite the vibration of polarized microtubules (MTs) and thus enable their use as a biosensor for the biophysical properties of MTs or cells. To facilitate the development, this paper aims to capture the EF-induced vibration modes and the associated frequency for MTs. The analyses were carried out based on a molecular structural mechanics model accounting for the structural details of MTs. Transverse vibration, radial breathing vibration and axial vibration were achieved for MTs subject to a transverse or an axial EF. The frequency shift and stiffness alteration of MTs were also examined due to the possible changes of the tubulin interactions in physiological or pathological processes. The strong correlation achieved between the tubulin interaction and MT vibration excited by EF provides a new avenue to a non-contacting technique for the structural or property changes in MTs, where frequency shift is used as a biomarker. This technique can be used for individual MTs and is possible for those in cells when the cytosol damping on MT vibrations is largely reduced by the unique features of MT–cytosol interface. |
published_date |
2019-02-28T03:59:15Z |
_version_ |
1763753020220243968 |
score |
11.021648 |