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A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study

Elizabeth Mudge, Patricia Price, Walkley Neal, Keith G. Harding, Tricia Price

Wound Repair and Regeneration, Volume: 22, Issue: 1, Pages: 43 - 51

Swansea University Author: Tricia Price

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DOI (Published version): 10.1111/wrr.12127

Abstract

It has been known for centuries that the application of larvae is useful to heal certain wounds by facilitating debridement of necrotic tissue,1 yet the efficacy of larval therapy continues to be debatable. This study compared the clinical effectiveness of a larval therapy dressing (BioFOAM) with a...

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Published in: Wound Repair and Regeneration
ISSN: 10671927
Published: 2014
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URI: https://cronfa.swan.ac.uk/Record/cronfa48705
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fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>48705</id><entry>2019-02-05</entry><title>A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study</title><swanseaauthors><author><sid>72b4943af96c97ef72977c31b9c29624</sid><firstname>Tricia</firstname><surname>Price</surname><name>Tricia Price</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-02-05</date><deptcode>FGMHL</deptcode><abstract>It has been known for centuries that the application of larvae is useful to heal certain wounds by facilitating debridement of necrotic tissue,1 yet the efficacy of larval therapy continues to be debatable. This study compared the clinical effectiveness of a larval therapy dressing (BioFOAM) with a standard debridement technique (Purilon gel; hydrogel) in terms of time to debridement of venous (VLU) or mixed arterial/venous (MLU) leg ulcers. Data analyses were conducted on 88 subjects. Sixty‐four subjects completed the full study. Of these, 31 of the 32 (96.9%) patients who completed treatment in the larvae arm debrided fully, compared with 11 of the 32 (34.4%) patients who completed the hydrogel arm. In addition, 42 (48%) ulcers fully debrided within the 21‐day intervention phase, 31 (67.4%) from the larvae arm (n = 46), and 11 (26.2%) from the hydrogel arm (n = 42), which was statistically significant (p = 0.001) in support of larvae. A statistically significant difference was also observed between treatment arms with regard to numbers of dressing changes during the intervention phase of the study (p &lt; 0.001) in that subjects in the larvae arm required significantly fewer dressing changes(mean = 2.83) than those in the hydrogel arm (mean = 5.40). There were no statistically significant differences in the clinical condition of the wound bed and surrounding skin by intervention. Subjects in the larvae arm experienced more ulcer‐related pain or discomfort than subjects in the hydrogel arm (p &lt; 0.001). This study provided good evidence to show that larval therapy, in the form of a BioFOAM dressing, debrided VLU and MLU considerably more quickly than a hydrogel, although the possibility of resloughing should be closely monitored.</abstract><type>Journal Article</type><journal>Wound Repair and Regeneration</journal><volume>22</volume><journalNumber>1</journalNumber><paginationStart>43</paginationStart><paginationEnd>51</paginationEnd><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>10671927</issnPrint><issnElectronic/><keywords/><publishedDay>31</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2014</publishedYear><publishedDate>2014-01-31</publishedDate><doi>10.1111/wrr.12127</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine, Health and Life Science - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGMHL</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2023-06-28T15:29:38.9660510</lastEdited><Created>2019-02-05T16:19:48.4904010</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Elizabeth</firstname><surname>Mudge</surname><order>1</order></author><author><firstname>Patricia</firstname><surname>Price</surname><order>2</order></author><author><firstname>Walkley</firstname><surname>Neal</surname><order>3</order></author><author><firstname>Keith G.</firstname><surname>Harding</surname><order>4</order></author><author><firstname>Tricia</firstname><surname>Price</surname><order>5</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling v2 48705 2019-02-05 A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study 72b4943af96c97ef72977c31b9c29624 Tricia Price Tricia Price true false 2019-02-05 FGMHL It has been known for centuries that the application of larvae is useful to heal certain wounds by facilitating debridement of necrotic tissue,1 yet the efficacy of larval therapy continues to be debatable. This study compared the clinical effectiveness of a larval therapy dressing (BioFOAM) with a standard debridement technique (Purilon gel; hydrogel) in terms of time to debridement of venous (VLU) or mixed arterial/venous (MLU) leg ulcers. Data analyses were conducted on 88 subjects. Sixty‐four subjects completed the full study. Of these, 31 of the 32 (96.9%) patients who completed treatment in the larvae arm debrided fully, compared with 11 of the 32 (34.4%) patients who completed the hydrogel arm. In addition, 42 (48%) ulcers fully debrided within the 21‐day intervention phase, 31 (67.4%) from the larvae arm (n = 46), and 11 (26.2%) from the hydrogel arm (n = 42), which was statistically significant (p = 0.001) in support of larvae. A statistically significant difference was also observed between treatment arms with regard to numbers of dressing changes during the intervention phase of the study (p < 0.001) in that subjects in the larvae arm required significantly fewer dressing changes(mean = 2.83) than those in the hydrogel arm (mean = 5.40). There were no statistically significant differences in the clinical condition of the wound bed and surrounding skin by intervention. Subjects in the larvae arm experienced more ulcer‐related pain or discomfort than subjects in the hydrogel arm (p < 0.001). This study provided good evidence to show that larval therapy, in the form of a BioFOAM dressing, debrided VLU and MLU considerably more quickly than a hydrogel, although the possibility of resloughing should be closely monitored. Journal Article Wound Repair and Regeneration 22 1 43 51 10671927 31 1 2014 2014-01-31 10.1111/wrr.12127 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2023-06-28T15:29:38.9660510 2019-02-05T16:19:48.4904010 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Elizabeth Mudge 1 Patricia Price 2 Walkley Neal 3 Keith G. Harding 4 Tricia Price 5
title A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study
spellingShingle A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study
Tricia Price
title_short A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study
title_full A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study
title_fullStr A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study
title_full_unstemmed A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study
title_sort A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study
author_id_str_mv 72b4943af96c97ef72977c31b9c29624
author_id_fullname_str_mv 72b4943af96c97ef72977c31b9c29624_***_Tricia Price
author Tricia Price
author2 Elizabeth Mudge
Patricia Price
Walkley Neal
Keith G. Harding
Tricia Price
format Journal article
container_title Wound Repair and Regeneration
container_volume 22
container_issue 1
container_start_page 43
publishDate 2014
institution Swansea University
issn 10671927
doi_str_mv 10.1111/wrr.12127
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description It has been known for centuries that the application of larvae is useful to heal certain wounds by facilitating debridement of necrotic tissue,1 yet the efficacy of larval therapy continues to be debatable. This study compared the clinical effectiveness of a larval therapy dressing (BioFOAM) with a standard debridement technique (Purilon gel; hydrogel) in terms of time to debridement of venous (VLU) or mixed arterial/venous (MLU) leg ulcers. Data analyses were conducted on 88 subjects. Sixty‐four subjects completed the full study. Of these, 31 of the 32 (96.9%) patients who completed treatment in the larvae arm debrided fully, compared with 11 of the 32 (34.4%) patients who completed the hydrogel arm. In addition, 42 (48%) ulcers fully debrided within the 21‐day intervention phase, 31 (67.4%) from the larvae arm (n = 46), and 11 (26.2%) from the hydrogel arm (n = 42), which was statistically significant (p = 0.001) in support of larvae. A statistically significant difference was also observed between treatment arms with regard to numbers of dressing changes during the intervention phase of the study (p < 0.001) in that subjects in the larvae arm required significantly fewer dressing changes(mean = 2.83) than those in the hydrogel arm (mean = 5.40). There were no statistically significant differences in the clinical condition of the wound bed and surrounding skin by intervention. Subjects in the larvae arm experienced more ulcer‐related pain or discomfort than subjects in the hydrogel arm (p < 0.001). This study provided good evidence to show that larval therapy, in the form of a BioFOAM dressing, debrided VLU and MLU considerably more quickly than a hydrogel, although the possibility of resloughing should be closely monitored.
published_date 2014-01-31T15:29:35Z
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