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A novel numerical modelling approach for keratoplasty eye procedure

Salahudeen Mohamed, Alberto Coccarelli Orcid Logo, Alessandro Mauro, Nicola Massarotti, Mario R. Romano, Vito Romano, Perumal Nithiarasu Orcid Logo

Biomechanics and Modeling in Mechanobiology

Swansea University Authors: Alberto Coccarelli Orcid Logo, Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1007/s10237-019-01156-y

Abstract

Objective of the work is to investigate stress and deformation that conrneal tissue and donor graft undergo during endothelial keratoplasty. In order to attach the donor graft to the cornea, different air bubble pressure profiles acting on the graft are considered. This study is carried out by emplo...

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Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa50157
first_indexed 2019-05-09T20:01:01Z
last_indexed 2019-07-17T21:31:55Z
id cronfa50157
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spelling 2019-07-17T17:27:30.7737346 v2 50157 2019-04-30 A novel numerical modelling approach for keratoplasty eye procedure 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2019-04-30 ACEM Objective of the work is to investigate stress and deformation that conrneal tissue and donor graft undergo during endothelial keratoplasty. In order to attach the donor graft to the cornea, different air bubble pressure profiles acting on the graft are considered. This study is carried out by employing a three-dimensional nonlinear finite element methodology, combined with a contact algorithm. The ocular tissues are treated as isotropic, hyper-elastic and nearly-incompressible materials. The contact algorithm, based on the penalty-based node-to-surface approach, is used to model the donor graft-corneal interface region. First, the proposed computational methodology is tested against benchmark data for bending of the plates over a cylinder. Then, the influence of geometrical and material parameters of the graft on the corneal contact-structural response is investigated. The results are presented in terms of Von Mises stress intensity, displacement and mean contact force. Results clearly indicate that the air bubble pressure plays a key role in the corneal stress and strain, as well as graft stiffness and thickness. Journal Article Biomechanics and Modeling in Mechanobiology 1617-7959 1617-7940 Keratoplasty, Cornea transplantation, Biomechanics, Hyper-elastic model, Finite element method, Contact mechanics 31 12 2019 2019-12-31 10.1007/s10237-019-01156-y COLLEGE NANME Aerospace, Civil, Electrical, and Mechanical Engineering COLLEGE CODE ACEM Swansea University 2019-07-17T17:27:30.7737346 2019-04-30T15:43:50.1367883 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Salahudeen Mohamed 1 Alberto Coccarelli 0000-0003-1511-9015 2 Alessandro Mauro 3 Nicola Massarotti 4 Mario R. Romano 5 Vito Romano 6 Perumal Nithiarasu 0000-0002-4901-2980 7 0050157-30042019154503.pdf mohamed2019.pdf 2019-04-30T15:45:03.5600000 Output 5533414 application/pdf Accepted Manuscript true 2020-05-11T00:00:00.0000000 true eng
title A novel numerical modelling approach for keratoplasty eye procedure
spellingShingle A novel numerical modelling approach for keratoplasty eye procedure
Alberto Coccarelli
Perumal Nithiarasu
title_short A novel numerical modelling approach for keratoplasty eye procedure
title_full A novel numerical modelling approach for keratoplasty eye procedure
title_fullStr A novel numerical modelling approach for keratoplasty eye procedure
title_full_unstemmed A novel numerical modelling approach for keratoplasty eye procedure
title_sort A novel numerical modelling approach for keratoplasty eye procedure
author_id_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d
3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto Coccarelli
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Alberto Coccarelli
Perumal Nithiarasu
author2 Salahudeen Mohamed
Alberto Coccarelli
Alessandro Mauro
Nicola Massarotti
Mario R. Romano
Vito Romano
Perumal Nithiarasu
format Journal article
container_title Biomechanics and Modeling in Mechanobiology
publishDate 2019
institution Swansea University
issn 1617-7959
1617-7940
doi_str_mv 10.1007/s10237-019-01156-y
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
document_store_str 1
active_str 0
description Objective of the work is to investigate stress and deformation that conrneal tissue and donor graft undergo during endothelial keratoplasty. In order to attach the donor graft to the cornea, different air bubble pressure profiles acting on the graft are considered. This study is carried out by employing a three-dimensional nonlinear finite element methodology, combined with a contact algorithm. The ocular tissues are treated as isotropic, hyper-elastic and nearly-incompressible materials. The contact algorithm, based on the penalty-based node-to-surface approach, is used to model the donor graft-corneal interface region. First, the proposed computational methodology is tested against benchmark data for bending of the plates over a cylinder. Then, the influence of geometrical and material parameters of the graft on the corneal contact-structural response is investigated. The results are presented in terms of Von Mises stress intensity, displacement and mean contact force. Results clearly indicate that the air bubble pressure plays a key role in the corneal stress and strain, as well as graft stiffness and thickness.
published_date 2019-12-31T19:50:53Z
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score 11.048042

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