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Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis

Ren-Jay Shei, Robert L. Dekerlegand, Kelly Mackintosh Orcid Logo, John D. Lowman, Melitta McNarry Orcid Logo

Sports Medicine - Open, Volume: 5, Issue: 1

Swansea University Authors: Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo

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DOI (Published version): 10.1186/s40798-019-0210-3

Abstract

Cystic fibrosis (CF) is an inherited, multi-system, life-limiting disease characterized by a progressive decline in lung function, which accounts for the majority of CF-related morbidity and mortality. Inspiratory muscle training (IMT) has been proposed as a rehabilitative strategy to treat respirat...

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Published in: Sports Medicine - Open
ISSN: 2199-1170 2198-9761
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa51284
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first_indexed 2019-07-31T22:30:21Z
last_indexed 2019-08-27T15:30:01Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-08-27T12:14:21.5742305</datestamp><bib-version>v2</bib-version><id>51284</id><entry>2019-07-31</entry><title>Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis</title><swanseaauthors><author><sid>bdb20e3f31bcccf95c7bc116070c4214</sid><ORCID>0000-0003-0355-6357</ORCID><firstname>Kelly</firstname><surname>Mackintosh</surname><name>Kelly Mackintosh</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>062f5697ff59f004bc8c713955988398</sid><ORCID>0000-0003-0813-7477</ORCID><firstname>Melitta</firstname><surname>McNarry</surname><name>Melitta McNarry</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-07-31</date><deptcode>STSC</deptcode><abstract>Cystic fibrosis (CF) is an inherited, multi-system, life-limiting disease characterized by a progressive decline in lung function, which accounts for the majority of CF-related morbidity and mortality. Inspiratory muscle training (IMT) has been proposed as a rehabilitative strategy to treat respiratory impairments associated with CF. However, despite evidence of therapeutic benefits in healthy and other clinical populations, the routine application of IMT in CF can neither be supported nor refuted due to the paucity of methodologically rigorous research. Specifically, the interpretation of available studies regarding the efficacy of IMT in CF is hampered by methodological threats to internal and external validity. As such, it is important to highlight the inherent risk of bias that differences in patient characteristics, IMT protocols, and outcome measurements present when synthesizing this literature prior to making final clinical judgments. Future studies are required to identify the characteristics of individuals who may respond to IMT and determine whether the controlled application of IMT can elicit meaningful improvements in physiological and patient-centered clinical outcomes. Given the equivocal evidence regarding its efficacy, IMT should be utilized on a case-by-case basis with sound clinical reasoning, rather than simply dismissed, until a rigorous evidence-based consensus has been reached.</abstract><type>Journal Article</type><journal>Sports Medicine - Open</journal><volume>5</volume><journalNumber>1</journalNumber><publisher/><issnPrint>2199-1170</issnPrint><issnElectronic>2198-9761</issnElectronic><keywords/><publishedDay>8</publishedDay><publishedMonth>8</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-08-08</publishedDate><doi>10.1186/s40798-019-0210-3</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-08-27T12:14:21.5742305</lastEdited><Created>2019-07-31T15:32:03.7520143</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences</level></path><authors><author><firstname>Ren-Jay</firstname><surname>Shei</surname><order>1</order></author><author><firstname>Robert L.</firstname><surname>Dekerlegand</surname><order>2</order></author><author><firstname>Kelly</firstname><surname>Mackintosh</surname><orcid>0000-0003-0355-6357</orcid><order>3</order></author><author><firstname>John D.</firstname><surname>Lowman</surname><order>4</order></author><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>5</order></author></authors><documents><document><filename>0051284-19082019095711.pdf</filename><originalFilename>shei2019(2).pdf</originalFilename><uploaded>2019-08-19T09:57:11.6070000</uploaded><type>Output</type><contentLength>974992</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-08-19T00:00:00.0000000</embargoDate><documentNotes>Distributed under the terms of a Creative Commons Attribution (CC-BY-4.0)</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2019-08-27T12:14:21.5742305 v2 51284 2019-07-31 Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 2019-07-31 STSC Cystic fibrosis (CF) is an inherited, multi-system, life-limiting disease characterized by a progressive decline in lung function, which accounts for the majority of CF-related morbidity and mortality. Inspiratory muscle training (IMT) has been proposed as a rehabilitative strategy to treat respiratory impairments associated with CF. However, despite evidence of therapeutic benefits in healthy and other clinical populations, the routine application of IMT in CF can neither be supported nor refuted due to the paucity of methodologically rigorous research. Specifically, the interpretation of available studies regarding the efficacy of IMT in CF is hampered by methodological threats to internal and external validity. As such, it is important to highlight the inherent risk of bias that differences in patient characteristics, IMT protocols, and outcome measurements present when synthesizing this literature prior to making final clinical judgments. Future studies are required to identify the characteristics of individuals who may respond to IMT and determine whether the controlled application of IMT can elicit meaningful improvements in physiological and patient-centered clinical outcomes. Given the equivocal evidence regarding its efficacy, IMT should be utilized on a case-by-case basis with sound clinical reasoning, rather than simply dismissed, until a rigorous evidence-based consensus has been reached. Journal Article Sports Medicine - Open 5 1 2199-1170 2198-9761 8 8 2019 2019-08-08 10.1186/s40798-019-0210-3 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2019-08-27T12:14:21.5742305 2019-07-31T15:32:03.7520143 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Ren-Jay Shei 1 Robert L. Dekerlegand 2 Kelly Mackintosh 0000-0003-0355-6357 3 John D. Lowman 4 Melitta McNarry 0000-0003-0813-7477 5 0051284-19082019095711.pdf shei2019(2).pdf 2019-08-19T09:57:11.6070000 Output 974992 application/pdf Version of Record true 2019-08-19T00:00:00.0000000 Distributed under the terms of a Creative Commons Attribution (CC-BY-4.0) true eng
title Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis
spellingShingle Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis
Kelly Mackintosh
Melitta McNarry
title_short Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis
title_full Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis
title_fullStr Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis
title_full_unstemmed Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis
title_sort Inspiration for the Future: The Role of Inspiratory Muscle Training in Cystic Fibrosis
author_id_str_mv bdb20e3f31bcccf95c7bc116070c4214
062f5697ff59f004bc8c713955988398
author_id_fullname_str_mv bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
062f5697ff59f004bc8c713955988398_***_Melitta McNarry
author Kelly Mackintosh
Melitta McNarry
author2 Ren-Jay Shei
Robert L. Dekerlegand
Kelly Mackintosh
John D. Lowman
Melitta McNarry
format Journal article
container_title Sports Medicine - Open
container_volume 5
container_issue 1
publishDate 2019
institution Swansea University
issn 2199-1170
2198-9761
doi_str_mv 10.1186/s40798-019-0210-3
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
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description Cystic fibrosis (CF) is an inherited, multi-system, life-limiting disease characterized by a progressive decline in lung function, which accounts for the majority of CF-related morbidity and mortality. Inspiratory muscle training (IMT) has been proposed as a rehabilitative strategy to treat respiratory impairments associated with CF. However, despite evidence of therapeutic benefits in healthy and other clinical populations, the routine application of IMT in CF can neither be supported nor refuted due to the paucity of methodologically rigorous research. Specifically, the interpretation of available studies regarding the efficacy of IMT in CF is hampered by methodological threats to internal and external validity. As such, it is important to highlight the inherent risk of bias that differences in patient characteristics, IMT protocols, and outcome measurements present when synthesizing this literature prior to making final clinical judgments. Future studies are required to identify the characteristics of individuals who may respond to IMT and determine whether the controlled application of IMT can elicit meaningful improvements in physiological and patient-centered clinical outcomes. Given the equivocal evidence regarding its efficacy, IMT should be utilized on a case-by-case basis with sound clinical reasoning, rather than simply dismissed, until a rigorous evidence-based consensus has been reached.
published_date 2019-08-08T04:03:07Z
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score 11.012678

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