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The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis

Mark Waldron Orcid Logo, Stephen David Patterson, Jamie Tallent, Owen Jeffries

Current Hypertension Reports, Volume: 20, Issue: 9

Swansea University Author: Mark Waldron Orcid Logo

Abstract

Purpose of ReviewThe aims of this meta-analysis were to investigate the effects of orally administered isolated taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans.Recent FindingsThere is growing evidence that taurine deficiency is associated with hypertensi...

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Published in: Current Hypertension Reports
ISSN: 1522-6417 1534-3111
Published: Springer 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa51422
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spelling 2019-10-07T15:26:48.5389218 v2 51422 2019-08-15 The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis 70db7c6c54d46f5e70b39e5ae0a056fa 0000-0002-2720-4615 Mark Waldron Mark Waldron true false 2019-08-15 STSC Purpose of ReviewThe aims of this meta-analysis were to investigate the effects of orally administered isolated taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans.Recent FindingsThere is growing evidence that taurine deficiency is associated with hypertension and that oral supplementation can have antihypertensive effects in humans. However, these investigations have been conducted across a number of decades and populations and have not been collectively reviewed. A search was performed using various databases in May 2018 and later screened using search criteria for eligibility. There were seven peer-reviewed studies meeting the inclusion criteria, encompassing 103 participants of varying age and health statuses. Taurine ingestion reduced SBP (Hedges’ g = − 0.70, 95% CI − 0.98 to − 0.41, P < 0.0001) and DBP (Hedges’ g = − 0.62, 95% CI − 0.91 to − 0.34, P < 0.0001). These results translated to mean ~ 3 mmHg reductions in both SBP (range = 0–15 mmHg) and DBP (range = 0–7 mmHg) following a range of doses (1 to 6 g/day) and supplementation periods (1 day to 12 weeks), with no adverse events reported.SummaryThese preliminary findings suggest that ingestion of taurine at the stated doses and supplementation periods can reduce blood pressure to a clinically relevant magnitude, without any adverse side effects. Future studies are needed to establish the effects of oral taurine supplementation on targeted pathologies and the optimal supplementation doses and periods. Journal Article Current Hypertension Reports 20 9 Springer 1522-6417 1534-3111 Hypertension, Taurine deficiency, Oral taurine 30 9 2018 2018-09-30 10.1007/s11906-018-0881-z https://doi.org/10.1007/s11906-018-0881-z COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2019-10-07T15:26:48.5389218 2019-08-15T15:44:31.2111640 College of Engineering Engineering Mark Waldron 0000-0002-2720-4615 1 Stephen David Patterson 2 Jamie Tallent 3 Owen Jeffries 4 0051422-07102019152331.pdf 51422.pdf 2019-10-07T15:23:31.2530000 Output 940859 application/pdf Accepted Manuscript true 2019-08-15T00:00:00.0000000 true eng
title The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
spellingShingle The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
Mark Waldron
title_short The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
title_full The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
title_fullStr The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
title_full_unstemmed The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
title_sort The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
author_id_str_mv 70db7c6c54d46f5e70b39e5ae0a056fa
author_id_fullname_str_mv 70db7c6c54d46f5e70b39e5ae0a056fa_***_Mark Waldron
author Mark Waldron
author2 Mark Waldron
Stephen David Patterson
Jamie Tallent
Owen Jeffries
format Journal article
container_title Current Hypertension Reports
container_volume 20
container_issue 9
publishDate 2018
institution Swansea University
issn 1522-6417
1534-3111
doi_str_mv 10.1007/s11906-018-0881-z
publisher Springer
college_str College of Engineering
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hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
url https://doi.org/10.1007/s11906-018-0881-z
document_store_str 1
active_str 0
description Purpose of ReviewThe aims of this meta-analysis were to investigate the effects of orally administered isolated taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans.Recent FindingsThere is growing evidence that taurine deficiency is associated with hypertension and that oral supplementation can have antihypertensive effects in humans. However, these investigations have been conducted across a number of decades and populations and have not been collectively reviewed. A search was performed using various databases in May 2018 and later screened using search criteria for eligibility. There were seven peer-reviewed studies meeting the inclusion criteria, encompassing 103 participants of varying age and health statuses. Taurine ingestion reduced SBP (Hedges’ g = − 0.70, 95% CI − 0.98 to − 0.41, P < 0.0001) and DBP (Hedges’ g = − 0.62, 95% CI − 0.91 to − 0.34, P < 0.0001). These results translated to mean ~ 3 mmHg reductions in both SBP (range = 0–15 mmHg) and DBP (range = 0–7 mmHg) following a range of doses (1 to 6 g/day) and supplementation periods (1 day to 12 weeks), with no adverse events reported.SummaryThese preliminary findings suggest that ingestion of taurine at the stated doses and supplementation periods can reduce blood pressure to a clinically relevant magnitude, without any adverse side effects. Future studies are needed to establish the effects of oral taurine supplementation on targeted pathologies and the optimal supplementation doses and periods.
published_date 2018-09-30T04:05:02Z
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