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Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover

Alison J. Peel, Konstans Wells Orcid Logo, John Giles, Victoria Boyd, Amy Burroughs, Daniel Edson, Gary Crameri, Michelle L. Baker, Hume Field, Lin-Fa Wang, Hamish McCallum, Raina Plowright, Nicholas Clark

Emerging Microbes & Infections, Volume: 8, Issue: 1, Pages: 1314 - 1323

Swansea University Author: Konstans Wells Orcid Logo

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DOI (Published version): 10.1080/22221751.2019.1661217

Abstract

Within host-parasite communities, viral co-circulation and co-infections of hosts are the norm, yet studies of significant emerging zoonoses tend to focus on a single parasite species within the host. Using a multiplexed paramyxovirus bead-based PCR on urine samples from Australian flying foxes, we...

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Published in: Emerging Microbes & Infections
Published: Taylor & Francis 2019
URI: https://cronfa.swan.ac.uk/Record/cronfa51486
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spelling 2019-09-27T15:06:28.9482669 v2 51486 2019-08-20 Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover d18166c31e89833c55ef0f2cbb551243 0000-0003-0377-2463 Konstans Wells Konstans Wells true false 2019-08-20 SBI Within host-parasite communities, viral co-circulation and co-infections of hosts are the norm, yet studies of significant emerging zoonoses tend to focus on a single parasite species within the host. Using a multiplexed paramyxovirus bead-based PCR on urine samples from Australian flying foxes, we show that multi-viral shedding from flying fox populations is common. We detected up to nine bat paramyxoviruses shed synchronously. Multi-viral shedding infrequently coalesced into an extreme, brief and spatially restricted shedding pulse, coinciding with peak spillover of Hendra virus, an emerging fatal zoonotic pathogen of high interest. Such extreme pulses of multi-viral shedding could easily be missed during routine surveillance yet have potentially serious consequences for spillover of novel pathogens to humans and domestic animal hosts. We also detected co-occurrence patterns suggestive of the presence of interactions among viruses, such as facilitation and cross-immunity. We propose that multiple viruses may be interacting, influencing the shedding and spillover of zoonotic pathogens. Understanding these interactions in the context of broader scale drivers, such as habitat loss, may help predict shedding pulses of Hendra virus and other fatal zoonoses. Journal Article Emerging Microbes & Infections 8 1 1314 1323 Taylor & Francis Pteropus, emerging infectious diseases, multi-viral, viral communities, zoonoses, disease ecology, co-occurrence analyses, Markov Random Fields 8 9 2019 2019-09-08 10.1080/22221751.2019.1661217 COLLEGE NANME Biosciences COLLEGE CODE SBI Swansea University AgriFutures Australia, Australian National Hendra Virus Research Program 2019-09-27T15:06:28.9482669 2019-08-20T15:13:35.5694913 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Alison J. Peel 1 Konstans Wells 0000-0003-0377-2463 2 John Giles 3 Victoria Boyd 4 Amy Burroughs 5 Daniel Edson 6 Gary Crameri 7 Michelle L. Baker 8 Hume Field 9 Lin-Fa Wang 10 Hamish McCallum 11 Raina Plowright 12 Nicholas Clark 13 0051486-07092019205635.pdf Peel_etal_2019_EmergMicorbesInfect.pdf 2019-09-07T20:56:35.2600000 Output 2432702 application/pdf Version of Record true 2019-09-07T00:00:00.0000000 Distributed under the terms of a Creative Commons Attribution (CC-BY-4.0) true eng
title Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover
spellingShingle Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover
Konstans Wells
title_short Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover
title_full Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover
title_fullStr Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover
title_full_unstemmed Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover
title_sort Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover
author_id_str_mv d18166c31e89833c55ef0f2cbb551243
author_id_fullname_str_mv d18166c31e89833c55ef0f2cbb551243_***_Konstans Wells
author Konstans Wells
author2 Alison J. Peel
Konstans Wells
John Giles
Victoria Boyd
Amy Burroughs
Daniel Edson
Gary Crameri
Michelle L. Baker
Hume Field
Lin-Fa Wang
Hamish McCallum
Raina Plowright
Nicholas Clark
format Journal article
container_title Emerging Microbes & Infections
container_volume 8
container_issue 1
container_start_page 1314
publishDate 2019
institution Swansea University
doi_str_mv 10.1080/22221751.2019.1661217
publisher Taylor & Francis
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description Within host-parasite communities, viral co-circulation and co-infections of hosts are the norm, yet studies of significant emerging zoonoses tend to focus on a single parasite species within the host. Using a multiplexed paramyxovirus bead-based PCR on urine samples from Australian flying foxes, we show that multi-viral shedding from flying fox populations is common. We detected up to nine bat paramyxoviruses shed synchronously. Multi-viral shedding infrequently coalesced into an extreme, brief and spatially restricted shedding pulse, coinciding with peak spillover of Hendra virus, an emerging fatal zoonotic pathogen of high interest. Such extreme pulses of multi-viral shedding could easily be missed during routine surveillance yet have potentially serious consequences for spillover of novel pathogens to humans and domestic animal hosts. We also detected co-occurrence patterns suggestive of the presence of interactions among viruses, such as facilitation and cross-immunity. We propose that multiple viruses may be interacting, influencing the shedding and spillover of zoonotic pathogens. Understanding these interactions in the context of broader scale drivers, such as habitat loss, may help predict shedding pulses of Hendra virus and other fatal zoonoses.
published_date 2019-09-08T04:03:23Z
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score 11.012678

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