Journal article 365 views
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review
Diabetes/Metabolism Research and Reviews, Volume: 32, Issue: Supp 1, Pages: 154 - 168
Swansea University Author: Tricia Price
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DOI (Published version): 10.1002/dmrr.2707
Abstract
The outcome of management of diabetic foot ulcers remains a challenge, andthere remains continuing uncertainty concerning optimal approaches to management.It is for these reasons that in 2008 and 2012, the International WorkingGroup of the Diabetic Foot (IWGDF) working group on wound healingpublishe...
| Published in: | Diabetes/Metabolism Research and Reviews |
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| ISSN: | 15207552 |
| Published: |
2016
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa51626 |
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| Abstract: |
The outcome of management of diabetic foot ulcers remains a challenge, andthere remains continuing uncertainty concerning optimal approaches to management.It is for these reasons that in 2008 and 2012, the International WorkingGroup of the Diabetic Foot (IWGDF) working group on wound healingpublished systematic reviews of the evidence to inform protocols for routinecare and to highlight areas, which should be considered for further study.The same working group has now updated this review by considering paperson the interventions to improve the healing of chronic ulcers published betweenJune 2010 and June 2014. Methodological quality of selected studieswas independently assessed by two reviewers using Scottish IntercollegiateGuidelines Network criteria. Selected studies fell into the following ten categories:sharp debridement and wound bed preparation with larvae or hydrotherapy;wound bed preparation using antiseptics, applications and dressingproducts; resection of the chronic wound; oxygen and other gases, compressionor negative pressure therapy; products designed to correct aspects ofwound biochemistry and cell biology associated with impaired wound healing;application of cells, including platelets and stem cells; bioengineered skin andskin grafts; electrical, electromagnetic, lasers, shockwaves and ultrasound andother systemic therapies, which did not fit in the aforementioned categories.Heterogeneity of studies prevented pooled analysis of results. Of the 2161 papersidentified, 30 were selected for grading following full text review. Thepresent report is an update of the earlier IWGDF systematic reviews, and theconclusion is similar: that with the possible exception of negative pressurewound therapy in post-operative wounds, there is little published evidence tojustify the use of newer therapies. Analysis of the evidence continues to presentdifficulties in this field as controlled studies remain few and the majoritycontinue to be of poor methodological quality |
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| Keywords: |
diabetes, diabetic foot, ulcer, wound healing, dressing |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
Supp 1 |
| Start Page: |
154 |
| End Page: |
168 |