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In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm

Feihu Zhao Orcid Logo, Myles J. Mc Garrigle, Ted J. Vaughan, Laoise M. McNamara

Biomechanics and Modeling in Mechanobiology, Volume: 17, Issue: 1, Pages: 5 - 18

Swansea University Author: Feihu Zhao Orcid Logo

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DOI (Published version): 10.1007/s10237-017-0941-3

Abstract

Mechanical stimulation, in the form of fluid perfusion or mechanical strain, enhances osteogenic differentiation and overall bone tissue formation by mesenchymal stems cells cultured in biomaterial scaffolds for tissue engineering applications. In silico techniques can be used to predict the mechani...

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Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa51684
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first_indexed 2019-09-04T20:46:37Z
last_indexed 2019-10-11T14:23:31Z
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spelling 2019-10-11T11:23:11.3239165 v2 51684 2019-09-04 In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2019-09-04 MEDE Mechanical stimulation, in the form of fluid perfusion or mechanical strain, enhances osteogenic differentiation and overall bone tissue formation by mesenchymal stems cells cultured in biomaterial scaffolds for tissue engineering applications. In silico techniques can be used to predict the mechanical environment within biomaterial scaffolds, and also the relationship between bone tissue regeneration and mechanical stimulation, and thereby inform conditions for bone tissue engineering experiments. In this study, we investigated bone tissue regeneration in an idealised hydrogel scaffold using a mechano-regulation model capable of predicting tissue differentiation, and specifically compared five loading cases, based on known experimental bioreactor regimes. These models predicted that low levels of mechanical loading, i.e. compression (0.5% strain), pore pressure of 10 kPa and a combination of compression (0.5%) and pore pressure (10 kPa), could induce more osteogenic differentiation and lead to the formation of a higher bone tissue fraction. In contrast greater volumes of cartilage and fibrous tissue fractions were predicted under higher levels of mechanical loading (i.e. compression strain of 5.0% and pore pressure of 100 kPa). The findings in this study may provide important information regarding the appropriate mechanical stimulation for in vitro bone tissue engineering experiments. Journal Article Biomechanics and Modeling in Mechanobiology 17 1 5 18 1617-7959 1617-7940 in silico bone tissue engineering, mechanical stimulation, mechano-regulation algorithm 28 2 2018 2018-02-28 10.1007/s10237-017-0941-3 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2019-10-11T11:23:11.3239165 2019-09-04T15:40:54.4367309 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Feihu Zhao 0000-0003-0515-6808 1 Myles J. Mc Garrigle 2 Ted J. Vaughan 3 Laoise M. McNamara 4
title In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm
spellingShingle In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm
Feihu Zhao
title_short In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm
title_full In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm
title_fullStr In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm
title_full_unstemmed In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm
title_sort In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm
author_id_str_mv 1c6e79b6edd08c88a8d17a241cd78630
author_id_fullname_str_mv 1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao
author Feihu Zhao
author2 Feihu Zhao
Myles J. Mc Garrigle
Ted J. Vaughan
Laoise M. McNamara
format Journal article
container_title Biomechanics and Modeling in Mechanobiology
container_volume 17
container_issue 1
container_start_page 5
publishDate 2018
institution Swansea University
issn 1617-7959
1617-7940
doi_str_mv 10.1007/s10237-017-0941-3
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description Mechanical stimulation, in the form of fluid perfusion or mechanical strain, enhances osteogenic differentiation and overall bone tissue formation by mesenchymal stems cells cultured in biomaterial scaffolds for tissue engineering applications. In silico techniques can be used to predict the mechanical environment within biomaterial scaffolds, and also the relationship between bone tissue regeneration and mechanical stimulation, and thereby inform conditions for bone tissue engineering experiments. In this study, we investigated bone tissue regeneration in an idealised hydrogel scaffold using a mechano-regulation model capable of predicting tissue differentiation, and specifically compared five loading cases, based on known experimental bioreactor regimes. These models predicted that low levels of mechanical loading, i.e. compression (0.5% strain), pore pressure of 10 kPa and a combination of compression (0.5%) and pore pressure (10 kPa), could induce more osteogenic differentiation and lead to the formation of a higher bone tissue fraction. In contrast greater volumes of cartilage and fibrous tissue fractions were predicted under higher levels of mechanical loading (i.e. compression strain of 5.0% and pore pressure of 100 kPa). The findings in this study may provide important information regarding the appropriate mechanical stimulation for in vitro bone tissue engineering experiments.
published_date 2018-02-28T04:03:40Z
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score 11.02586

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