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Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
Biomechanics and Modeling in Mechanobiology, Volume: 14, Issue: 2, Pages: 231 - 243
Swansea University Author:
Feihu Zhao
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DOI (Published version): 10.1007/s10237-014-0599-z
Abstract
Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial scaffolds in vitro. However, the precise mechanisms by which such stimulation...
Published in: | Biomechanics and Modeling in Mechanobiology |
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ISSN: | 1617-7959 1617-7940 |
Published: |
2015
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URI: | https://cronfa.swan.ac.uk/Record/cronfa51692 |
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<?xml version="1.0"?><rfc1807><datestamp>2023-02-21T16:41:35.6086491</datestamp><bib-version>v2</bib-version><id>51692</id><entry>2019-09-04</entry><title>Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold</title><swanseaauthors><author><sid>1c6e79b6edd08c88a8d17a241cd78630</sid><ORCID>0000-0003-0515-6808</ORCID><firstname>Feihu</firstname><surname>Zhao</surname><name>Feihu Zhao</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-09-04</date><deptcode>MEDE</deptcode><abstract>Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial scaffolds in vitro. However, the precise mechanisms by which such stimulation enhances bone regeneration is not yet clear. The physical environment within a scaffold under perfusion is extremely complex and requires a multiscale and multiphysics approach to study the mechanical stimulation of cells. In this study, we aim to determine the mechanical stimulation of osteoblasts seeded in a biomaterial scaffold under flow perfusion and mechanical compression using multiscale modelling by twoway fluid–structure interaction and FE approaches. The mechanical stimulation, in terms of wall shear stress (WSS) and strain in osteoblasts, is quantified at different locations within the scaffold for cells of different morphologies (i.e. attached, bridged). The results show that 75.4% of scaffold surface has a WSS of 0.1–10 mPa, which indicates the likelihood of bone cell differentiation at these locations. For attached and bridged osteoblasts, the maximum strains are 397 and 177,200με, respectively. Additionally, the results from mechanical compression show that attached cells are more stimulated (maximum strain = 22, 600 με) than bridged cells (maximum strain = 10, 000 με). Such information is important for understanding the biological response of osteoblasts under in vitro stimulation. Finally, a combination of perfusion and compression of a tissue engineering scaffold is suggested for osteogenic differentiation.</abstract><type>Journal Article</type><journal>Biomechanics and Modeling in Mechanobiology</journal><volume>14</volume><journalNumber>2</journalNumber><paginationStart>231</paginationStart><paginationEnd>243</paginationEnd><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1617-7959</issnPrint><issnElectronic>1617-7940</issnElectronic><keywords>Fluid–structure interaction, multiscale modelling, osteoblast, tissue engineered scaffold</keywords><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2015</publishedYear><publishedDate>2015-04-01</publishedDate><doi>10.1007/s10237-014-0599-z</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2023-02-21T16:41:35.6086491</lastEdited><Created>2019-09-04T15:41:08.0885976</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Feihu</firstname><surname>Zhao</surname><orcid>0000-0003-0515-6808</orcid><order>1</order></author><author><firstname>Ted J.</firstname><surname>Vaughan</surname><order>2</order></author><author><firstname>Laoise M.</firstname><surname>Mcnamara</surname><order>3</order></author></authors><documents/><OutputDurs/></rfc1807> |
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2023-02-21T16:41:35.6086491 v2 51692 2019-09-04 Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2019-09-04 MEDE Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial scaffolds in vitro. However, the precise mechanisms by which such stimulation enhances bone regeneration is not yet clear. The physical environment within a scaffold under perfusion is extremely complex and requires a multiscale and multiphysics approach to study the mechanical stimulation of cells. In this study, we aim to determine the mechanical stimulation of osteoblasts seeded in a biomaterial scaffold under flow perfusion and mechanical compression using multiscale modelling by twoway fluid–structure interaction and FE approaches. The mechanical stimulation, in terms of wall shear stress (WSS) and strain in osteoblasts, is quantified at different locations within the scaffold for cells of different morphologies (i.e. attached, bridged). The results show that 75.4% of scaffold surface has a WSS of 0.1–10 mPa, which indicates the likelihood of bone cell differentiation at these locations. For attached and bridged osteoblasts, the maximum strains are 397 and 177,200με, respectively. Additionally, the results from mechanical compression show that attached cells are more stimulated (maximum strain = 22, 600 με) than bridged cells (maximum strain = 10, 000 με). Such information is important for understanding the biological response of osteoblasts under in vitro stimulation. Finally, a combination of perfusion and compression of a tissue engineering scaffold is suggested for osteogenic differentiation. Journal Article Biomechanics and Modeling in Mechanobiology 14 2 231 243 1617-7959 1617-7940 Fluid–structure interaction, multiscale modelling, osteoblast, tissue engineered scaffold 1 4 2015 2015-04-01 10.1007/s10237-014-0599-z COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2023-02-21T16:41:35.6086491 2019-09-04T15:41:08.0885976 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Feihu Zhao 0000-0003-0515-6808 1 Ted J. Vaughan 2 Laoise M. Mcnamara 3 |
title |
Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold |
spellingShingle |
Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold Feihu Zhao |
title_short |
Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold |
title_full |
Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold |
title_fullStr |
Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold |
title_full_unstemmed |
Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold |
title_sort |
Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold |
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1c6e79b6edd08c88a8d17a241cd78630 |
author_id_fullname_str_mv |
1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao |
author |
Feihu Zhao |
author2 |
Feihu Zhao Ted J. Vaughan Laoise M. Mcnamara |
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Journal article |
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Biomechanics and Modeling in Mechanobiology |
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14 |
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231 |
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2015 |
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Swansea University |
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1617-7959 1617-7940 |
doi_str_mv |
10.1007/s10237-014-0599-z |
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Faculty of Science and Engineering |
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Faculty of Science and Engineering |
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School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering |
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description |
Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial scaffolds in vitro. However, the precise mechanisms by which such stimulation enhances bone regeneration is not yet clear. The physical environment within a scaffold under perfusion is extremely complex and requires a multiscale and multiphysics approach to study the mechanical stimulation of cells. In this study, we aim to determine the mechanical stimulation of osteoblasts seeded in a biomaterial scaffold under flow perfusion and mechanical compression using multiscale modelling by twoway fluid–structure interaction and FE approaches. The mechanical stimulation, in terms of wall shear stress (WSS) and strain in osteoblasts, is quantified at different locations within the scaffold for cells of different morphologies (i.e. attached, bridged). The results show that 75.4% of scaffold surface has a WSS of 0.1–10 mPa, which indicates the likelihood of bone cell differentiation at these locations. For attached and bridged osteoblasts, the maximum strains are 397 and 177,200με, respectively. Additionally, the results from mechanical compression show that attached cells are more stimulated (maximum strain = 22, 600 με) than bridged cells (maximum strain = 10, 000 με). Such information is important for understanding the biological response of osteoblasts under in vitro stimulation. Finally, a combination of perfusion and compression of a tissue engineering scaffold is suggested for osteogenic differentiation. |
published_date |
2015-04-01T04:03:41Z |
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1763753299055476736 |
score |
11.021648 |