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Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold

Feihu Zhao Orcid Logo, Ted J. Vaughan, Laoise M. Mcnamara

Biomechanics and Modeling in Mechanobiology, Volume: 14, Issue: 2, Pages: 231 - 243

Swansea University Author: Feihu Zhao Orcid Logo

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DOI (Published version): 10.1007/s10237-014-0599-z

Abstract

Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial scaffolds in vitro. However, the precise mechanisms by which such stimulation...

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Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa51692
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spelling 2023-02-21T16:41:35.6086491 v2 51692 2019-09-04 Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2019-09-04 MEDE Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial scaffolds in vitro. However, the precise mechanisms by which such stimulation enhances bone regeneration is not yet clear. The physical environment within a scaffold under perfusion is extremely complex and requires a multiscale and multiphysics approach to study the mechanical stimulation of cells. In this study, we aim to determine the mechanical stimulation of osteoblasts seeded in a biomaterial scaffold under flow perfusion and mechanical compression using multiscale modelling by twoway fluid–structure interaction and FE approaches. The mechanical stimulation, in terms of wall shear stress (WSS) and strain in osteoblasts, is quantified at different locations within the scaffold for cells of different morphologies (i.e. attached, bridged). The results show that 75.4% of scaffold surface has a WSS of 0.1–10 mPa, which indicates the likelihood of bone cell differentiation at these locations. For attached and bridged osteoblasts, the maximum strains are 397 and 177,200με, respectively. Additionally, the results from mechanical compression show that attached cells are more stimulated (maximum strain = 22, 600 με) than bridged cells (maximum strain = 10, 000 με). Such information is important for understanding the biological response of osteoblasts under in vitro stimulation. Finally, a combination of perfusion and compression of a tissue engineering scaffold is suggested for osteogenic differentiation. Journal Article Biomechanics and Modeling in Mechanobiology 14 2 231 243 1617-7959 1617-7940 Fluid–structure interaction, multiscale modelling, osteoblast, tissue engineered scaffold 1 4 2015 2015-04-01 10.1007/s10237-014-0599-z COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2023-02-21T16:41:35.6086491 2019-09-04T15:41:08.0885976 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Feihu Zhao 0000-0003-0515-6808 1 Ted J. Vaughan 2 Laoise M. Mcnamara 3
title Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
spellingShingle Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
Feihu Zhao
title_short Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
title_full Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
title_fullStr Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
title_full_unstemmed Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
title_sort Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
author_id_str_mv 1c6e79b6edd08c88a8d17a241cd78630
author_id_fullname_str_mv 1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao
author Feihu Zhao
author2 Feihu Zhao
Ted J. Vaughan
Laoise M. Mcnamara
format Journal article
container_title Biomechanics and Modeling in Mechanobiology
container_volume 14
container_issue 2
container_start_page 231
publishDate 2015
institution Swansea University
issn 1617-7959
1617-7940
doi_str_mv 10.1007/s10237-014-0599-z
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial scaffolds in vitro. However, the precise mechanisms by which such stimulation enhances bone regeneration is not yet clear. The physical environment within a scaffold under perfusion is extremely complex and requires a multiscale and multiphysics approach to study the mechanical stimulation of cells. In this study, we aim to determine the mechanical stimulation of osteoblasts seeded in a biomaterial scaffold under flow perfusion and mechanical compression using multiscale modelling by twoway fluid–structure interaction and FE approaches. The mechanical stimulation, in terms of wall shear stress (WSS) and strain in osteoblasts, is quantified at different locations within the scaffold for cells of different morphologies (i.e. attached, bridged). The results show that 75.4% of scaffold surface has a WSS of 0.1–10 mPa, which indicates the likelihood of bone cell differentiation at these locations. For attached and bridged osteoblasts, the maximum strains are 397 and 177,200με, respectively. Additionally, the results from mechanical compression show that attached cells are more stimulated (maximum strain = 22, 600 με) than bridged cells (maximum strain = 10, 000 με). Such information is important for understanding the biological response of osteoblasts under in vitro stimulation. Finally, a combination of perfusion and compression of a tissue engineering scaffold is suggested for osteogenic differentiation.
published_date 2015-04-01T04:03:41Z
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score 11.035634

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