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Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
Prostaglandins & Other Lipid Mediators, Volume: 147, Start page: 106381
Swansea University Authors:
William Griffiths , Yuqin Wang
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DOI (Published version): 10.1016/j.prostaglandins.2019.106381
Abstract
There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol...
Published in: | Prostaglandins & Other Lipid Mediators |
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ISSN: | 1098-8823 |
Published: |
Elsevier BV
2020
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URI: | https://cronfa.swan.ac.uk/Record/cronfa52696 |
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2019-11-10T04:14:16Z |
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2020-10-29T13:18:59.4724866 v2 52696 2019-11-10 Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 2019-11-10 BMS There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in health and disease. Journal Article Prostaglandins & Other Lipid Mediators 147 106381 Elsevier BV 1098-8823 Hydroxycholesterol, Dihydroxycholesterol, Epoxycholesterol, G protein-coupled receptor, Epstein Barr virus induced gene 2, Smoothened, Hedgehog signaling, Nuclear receptor, Liver X receptor 1 4 2020 2020-04-01 10.1016/j.prostaglandins.2019.106381 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University UKRI, BB/N015932/1 2020-10-29T13:18:59.4724866 2019-11-10T01:50:13.5205824 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 Yuqin Wang 0000-0002-3063-3066 2 52696__16045__59400e66d6e04bbbaf3068a362152f76.pdf 52696.pdf 2019-12-05T11:22:31.8146028 Output 1753865 application/pdf Version of Record true Distributed under the terms of a Creative Commons Attribution 4.0 (CC-BY) Licence true eng https://creativecommons.org/licenses/by/4.0/ 4 true true |
title |
Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites |
spellingShingle |
Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites William Griffiths Yuqin Wang |
title_short |
Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites |
title_full |
Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites |
title_fullStr |
Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites |
title_full_unstemmed |
Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites |
title_sort |
Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites |
author_id_str_mv |
3316b1d1b524be1831790933eed1c26e c92729b58622f9fdf6a0e7d8f4ce5081 |
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3316b1d1b524be1831790933eed1c26e_***_William Griffiths c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang |
author |
William Griffiths Yuqin Wang |
author2 |
William Griffiths Yuqin Wang |
format |
Journal article |
container_title |
Prostaglandins & Other Lipid Mediators |
container_volume |
147 |
container_start_page |
106381 |
publishDate |
2020 |
institution |
Swansea University |
issn |
1098-8823 |
doi_str_mv |
10.1016/j.prostaglandins.2019.106381 |
publisher |
Elsevier BV |
college_str |
Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
document_store_str |
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description |
There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in health and disease. |
published_date |
2020-04-01T04:05:13Z |
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1763753394963480576 |
score |
11.021648 |