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Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes
Ruthenium Complexes, Pages: 221 - 238
Swansea University Author:
Martin Gill
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DOI (Published version): 10.1002/9783527695225.ch11
Abstract
This chapter describes the development of kinetically inert ruthenium(II) polypyridyl complexes (RPCs) as cellular imaging agents and as potential therapeutics. By employing planar polypyridyl coordination ligands, these complexes may interact with DNA by a multitude of reversible binding mechanisms...
Published in: | Ruthenium Complexes |
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ISBN: | 9783527339570 9783527695225 |
Published: |
Weinheim, Germany
Wiley-VCH Verlag GmbH & Co. KGaA
2018
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Online Access: |
http://dx.doi.org/10.1002/9783527695225.ch11 |
URI: | https://cronfa.swan.ac.uk/Record/cronfa52957 |
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Abstract: |
This chapter describes the development of kinetically inert ruthenium(II) polypyridyl complexes (RPCs) as cellular imaging agents and as potential therapeutics. By employing planar polypyridyl coordination ligands, these complexes may interact with DNA by a multitude of reversible binding mechanisms, often with distinctive photophysical changes upon association. We discuss the chemical and biological approaches employed to promote cellular uptake and successful intracellular DNA targeting for complexes that bind DNA with high affinities and specificities. We describe the progress made in the past decade by leading researchers, citing recent examples of primary research in the literature. In addition to this, several milestone papers and key reviews are highlighted to provide wider context and further reading. Finally, we examine how this developing knowledge may provide an indication for future biomedical applications for this exciting area of ruthenium chemistry. |
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Keywords: |
ruthenium(II), polypyridyl, DNA, luminescence, microscopy |
College: |
Faculty of Science and Engineering |
Start Page: |
221 |
End Page: |
238 |