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Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes

Martin Gill Orcid Logo, Jim A. Thomas

Ruthenium Complexes, Pages: 221 - 238

Swansea University Author: Martin Gill Orcid Logo

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DOI (Published version): 10.1002/9783527695225.ch11

Abstract

This chapter describes the development of kinetically inert ruthenium(II) polypyridyl complexes (RPCs) as cellular imaging agents and as potential therapeutics. By employing planar polypyridyl coordination ligands, these complexes may interact with DNA by a multitude of reversible binding mechanisms...

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Published in: Ruthenium Complexes
ISBN: 9783527339570 9783527695225
Published: Weinheim, Germany Wiley-VCH Verlag GmbH & Co. KGaA 2018
Online Access: http://dx.doi.org/10.1002/9783527695225.ch11
URI: https://cronfa.swan.ac.uk/Record/cronfa52957
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Abstract: This chapter describes the development of kinetically inert ruthenium(II) polypyridyl complexes (RPCs) as cellular imaging agents and as potential therapeutics. By employing planar polypyridyl coordination ligands, these complexes may interact with DNA by a multitude of reversible binding mechanisms, often with distinctive photophysical changes upon association. We discuss the chemical and biological approaches employed to promote cellular uptake and successful intracellular DNA targeting for complexes that bind DNA with high affinities and specificities. We describe the progress made in the past decade by leading researchers, citing recent examples of primary research in the literature. In addition to this, several milestone papers and key reviews are highlighted to provide wider context and further reading. Finally, we examine how this developing knowledge may provide an indication for future biomedical applications for this exciting area of ruthenium chemistry.
Keywords: ruthenium(II), polypyridyl, DNA, luminescence, microscopy
College: Faculty of Science and Engineering
Start Page: 221
End Page: 238