No Cover Image

Journal article 777 views 89 downloads

Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months

Sarah Prior Orcid Logo, Rachel Churm Orcid Logo, Thinzar Min, Gareth Dunseath Orcid Logo, J. D. Barry, Jeffrey Stephens Orcid Logo

Obesity Surgery, Volume: 30, Issue: 6, Pages: 2243 - 2250

Swansea University Authors: Sarah Prior Orcid Logo, Rachel Churm Orcid Logo, Thinzar Min, Gareth Dunseath Orcid Logo, Jeffrey Stephens Orcid Logo

  • 53472.pdf

    PDF | Version of Record

    Released under the terms of a Creative Commons Attribution 4.0 International License (CC-BY).

    Download (468.6KB)

Abstract

BackgroundBariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction.ObjectivesThe aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 partici...

Full description

Published in: Obesity Surgery
ISSN: 0960-8923 1708-0428
Published: Springer Science and Business Media LLC 2020
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa53472
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: BackgroundBariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction.ObjectivesThe aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 participants preoperatively and 1 month and 6 months postoperatively. The focus was on a sample of patients with impaired glucose tolerance and type 2 diabetes (T2D).SettingMorriston Hospital, UK.MethodsProspective study comprising of 55 participants with impaired glucose homeostasis and T2D undergoing SG (mean body mass index [BMI] 50.4 kg/m2, mean glycated haemoglobin [A1C] 7.4%). Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP) were performed during oral glucose tolerance testing preoperatively and 1 and 6 months postoperatively. Areas under the curve (AUC) were examined at 30, 60, and 120 min.ResultsWe observed significant improvements in measures of obesity, as well as static and dynamic measures of glucose, insulin, C-peptide and HOMA. Furthermore, significant increases in GLP-1 response as early as 6 months postoperatively were also seen.ConclusionsTo our knowledge, no study has examined the detailed dynamic changes in glucose and insulin homeostasis in this number of participants undergoing SG in relation to incretin hormones GIP and GLP-1. This current study supports the role of SG for the treatment of obesity-related glucose dysregulation.
Keywords: Type 2 diabetes; Impaired glucose tolerance; Incretin; Sleeve gastrectomy
College: Faculty of Medicine, Health and Life Sciences
Issue: 6
Start Page: 2243
End Page: 2250