No Cover Image

Journal article 661 views 193 downloads

The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer

D.J.J. Farnell, J. Staffurth, S. Sivell, S. Ahmedzai, J. Andreyev, J. Green, D.S. Sanders, C.J. Ferguson, Sara Pickett, A. Muls, R. O'Shea, S.H. Campbell, S.E. Taylor, A. Nelson

Clinical and Translational Radiation Oncology, Volume: 21, Pages: 98 - 103

Swansea University Author: Sara Pickett

  • 53625.pdf

    PDF | Version of Record

    This is an open access article released under the terms of a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND).

    Download (759.09KB)

Check full text

DOI (Published version): 10.1016/j.ctro.2020.02.002

Abstract

There is an increasing need to measure treatment-related side effects in normal tissues following cancer therapy. The ALERT-B (Assessment of Late Effects of RadioTherapy - Bowel) questionnaire is a screening tool that is composed of four items related specifically to bowel symptoms. Those patients t...

Full description

Published in: Clinical and Translational Radiation Oncology
ISSN: 2405-6308
Published: Elsevier BV 2020
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa53625
first_indexed 2020-02-25T13:50:51Z
last_indexed 2025-04-10T05:37:52Z
id cronfa53625
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2025-04-09T15:15:07.0090489</datestamp><bib-version>v2</bib-version><id>53625</id><entry>2020-02-25</entry><title>The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer</title><swanseaauthors><author><sid>f150350ed02c423c668749b0f9e703cc</sid><ORCID/><firstname>Sara</firstname><surname>Pickett</surname><name>Sara Pickett</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2020-02-25</date><abstract>There is an increasing need to measure treatment-related side effects in normal tissues following cancer therapy. The ALERT-B (Assessment of Late Effects of RadioTherapy - Bowel) questionnaire is a screening tool that is composed of four items related specifically to bowel symptoms. Those patients that respond with a &#x201C;yes&#x201D; to any of these items are referred on to gastroenterologist in order to improve the long-term consequences of these side effects of radiological treatment. Here we wish to test the ability of this questionnaire to identify these subsequent gastroenterological complications by tracking prostate cancer patients that were positive with respect to ALERT-B. We also carry out receiver-operator curve (ROC) analysis for baseline data for an overall ALERT-B questionnaire score with respect to subscale data for the Gastrointestinal Symptom Rating Scale (GSRS) and the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. 84.4% and 95.7% of patients identified by the ALERT-B questionnaire demonstrated complications diagnosed at 6 and 12 months post-treatment, respectively. ROC curve analysis of baseline data showed that ALERT-B detected clinically relevant levels of side effects established at baseline by the GSRS diarrhoea subscale (AUC = 0.867, 95% CI = 0.795 to 0.926) and at the minimally important level of side effects for the EPIC bowel subscale (AUC = 0.765, 95% CI = 0.617 to 0.913). These results show that ALERT-B provides a simple and effective screening tool for identifying gastroenterological complications after treatment for prostate cancer.</abstract><type>Journal Article</type><journal>Clinical and Translational Radiation Oncology</journal><volume>21</volume><journalNumber/><paginationStart>98</paginationStart><paginationEnd>103</paginationEnd><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2405-6308</issnElectronic><keywords>Prostate cancer; Radiotherapy; Gastroenterological late effects; ROC analysis</keywords><publishedDay>1</publishedDay><publishedMonth>3</publishedMonth><publishedYear>2020</publishedYear><publishedDate>2020-03-01</publishedDate><doi>10.1016/j.ctro.2020.02.002</doi><url/><notes/><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>The work represented in this manuscript, including the posts of AN and SS was supported by core funding from Marie Curie to the Marie Curie Palliative Care Research Centre, Cardiff University (grant reference: MCCC-FCO-14-C). The results presented here were conducted as part of the EAGLE study, funded by Prostate Cancer UK&#x2019;s TrueNTH initiative (Grant Reference 250-55).</funders><projectreference/><lastEdited>2025-04-09T15:15:07.0090489</lastEdited><Created>2020-02-25T09:47:36.9578359</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Public Health</level></path><authors><author><firstname>D.J.J.</firstname><surname>Farnell</surname><order>1</order></author><author><firstname>J.</firstname><surname>Staffurth</surname><order>2</order></author><author><firstname>S.</firstname><surname>Sivell</surname><order>3</order></author><author><firstname>S.</firstname><surname>Ahmedzai</surname><order>4</order></author><author><firstname>J.</firstname><surname>Andreyev</surname><order>5</order></author><author><firstname>J.</firstname><surname>Green</surname><order>6</order></author><author><firstname>D.S.</firstname><surname>Sanders</surname><order>7</order></author><author><firstname>C.J.</firstname><surname>Ferguson</surname><order>8</order></author><author><firstname>Sara</firstname><surname>Pickett</surname><orcid/><order>9</order></author><author><firstname>A.</firstname><surname>Muls</surname><order>10</order></author><author><firstname>R.</firstname><surname>O'Shea</surname><order>11</order></author><author><firstname>S.H.</firstname><surname>Campbell</surname><order>12</order></author><author><firstname>S.E.</firstname><surname>Taylor</surname><order>13</order></author><author><firstname>A.</firstname><surname>Nelson</surname><order>14</order></author></authors><documents><document><filename>53625__16683__a6740a7b886a412ca7255cc5b281918d.pdf</filename><originalFilename>53625.pdf</originalFilename><uploaded>2020-02-25T09:50:11.2402106</uploaded><type>Output</type><contentLength>777309</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>This is an open access article released under the terms of a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2025-04-09T15:15:07.0090489 v2 53625 2020-02-25 The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer f150350ed02c423c668749b0f9e703cc Sara Pickett Sara Pickett true false 2020-02-25 There is an increasing need to measure treatment-related side effects in normal tissues following cancer therapy. The ALERT-B (Assessment of Late Effects of RadioTherapy - Bowel) questionnaire is a screening tool that is composed of four items related specifically to bowel symptoms. Those patients that respond with a “yes” to any of these items are referred on to gastroenterologist in order to improve the long-term consequences of these side effects of radiological treatment. Here we wish to test the ability of this questionnaire to identify these subsequent gastroenterological complications by tracking prostate cancer patients that were positive with respect to ALERT-B. We also carry out receiver-operator curve (ROC) analysis for baseline data for an overall ALERT-B questionnaire score with respect to subscale data for the Gastrointestinal Symptom Rating Scale (GSRS) and the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. 84.4% and 95.7% of patients identified by the ALERT-B questionnaire demonstrated complications diagnosed at 6 and 12 months post-treatment, respectively. ROC curve analysis of baseline data showed that ALERT-B detected clinically relevant levels of side effects established at baseline by the GSRS diarrhoea subscale (AUC = 0.867, 95% CI = 0.795 to 0.926) and at the minimally important level of side effects for the EPIC bowel subscale (AUC = 0.765, 95% CI = 0.617 to 0.913). These results show that ALERT-B provides a simple and effective screening tool for identifying gastroenterological complications after treatment for prostate cancer. Journal Article Clinical and Translational Radiation Oncology 21 98 103 Elsevier BV 2405-6308 Prostate cancer; Radiotherapy; Gastroenterological late effects; ROC analysis 1 3 2020 2020-03-01 10.1016/j.ctro.2020.02.002 COLLEGE NANME COLLEGE CODE Swansea University Another institution paid the OA fee The work represented in this manuscript, including the posts of AN and SS was supported by core funding from Marie Curie to the Marie Curie Palliative Care Research Centre, Cardiff University (grant reference: MCCC-FCO-14-C). The results presented here were conducted as part of the EAGLE study, funded by Prostate Cancer UK’s TrueNTH initiative (Grant Reference 250-55). 2025-04-09T15:15:07.0090489 2020-02-25T09:47:36.9578359 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health D.J.J. Farnell 1 J. Staffurth 2 S. Sivell 3 S. Ahmedzai 4 J. Andreyev 5 J. Green 6 D.S. Sanders 7 C.J. Ferguson 8 Sara Pickett 9 A. Muls 10 R. O'Shea 11 S.H. Campbell 12 S.E. Taylor 13 A. Nelson 14 53625__16683__a6740a7b886a412ca7255cc5b281918d.pdf 53625.pdf 2020-02-25T09:50:11.2402106 Output 777309 application/pdf Version of Record true This is an open access article released under the terms of a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND). true eng https://creativecommons.org/licenses/
title The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer
spellingShingle The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer
Sara Pickett
title_short The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer
title_full The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer
title_fullStr The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer
title_full_unstemmed The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer
title_sort The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer
author_id_str_mv f150350ed02c423c668749b0f9e703cc
author_id_fullname_str_mv f150350ed02c423c668749b0f9e703cc_***_Sara Pickett
author Sara Pickett
author2 D.J.J. Farnell
J. Staffurth
S. Sivell
S. Ahmedzai
J. Andreyev
J. Green
D.S. Sanders
C.J. Ferguson
Sara Pickett
A. Muls
R. O'Shea
S.H. Campbell
S.E. Taylor
A. Nelson
format Journal article
container_title Clinical and Translational Radiation Oncology
container_volume 21
container_start_page 98
publishDate 2020
institution Swansea University
issn 2405-6308
doi_str_mv 10.1016/j.ctro.2020.02.002
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Public Health{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Public Health
document_store_str 1
active_str 0
description There is an increasing need to measure treatment-related side effects in normal tissues following cancer therapy. The ALERT-B (Assessment of Late Effects of RadioTherapy - Bowel) questionnaire is a screening tool that is composed of four items related specifically to bowel symptoms. Those patients that respond with a “yes” to any of these items are referred on to gastroenterologist in order to improve the long-term consequences of these side effects of radiological treatment. Here we wish to test the ability of this questionnaire to identify these subsequent gastroenterological complications by tracking prostate cancer patients that were positive with respect to ALERT-B. We also carry out receiver-operator curve (ROC) analysis for baseline data for an overall ALERT-B questionnaire score with respect to subscale data for the Gastrointestinal Symptom Rating Scale (GSRS) and the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. 84.4% and 95.7% of patients identified by the ALERT-B questionnaire demonstrated complications diagnosed at 6 and 12 months post-treatment, respectively. ROC curve analysis of baseline data showed that ALERT-B detected clinically relevant levels of side effects established at baseline by the GSRS diarrhoea subscale (AUC = 0.867, 95% CI = 0.795 to 0.926) and at the minimally important level of side effects for the EPIC bowel subscale (AUC = 0.765, 95% CI = 0.617 to 0.913). These results show that ALERT-B provides a simple and effective screening tool for identifying gastroenterological complications after treatment for prostate cancer.
published_date 2020-03-01T04:45:09Z
_version_ 1856802766971731968
score 11.09611

Similar Items