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Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis / Max L. Eckstein; Olivia McCarthy; Norbert J. Tripolt; Alexander Müller; Philipp Birnbaumer; Peter N. Pferschy; Peter Hofmann; Richard Bracken; Harald Sourij; Othmar Moser

Canadian Journal of Diabetes

Swansea University Authors: Olivia, McCarthy, Richard, Bracken

  • Accepted Manuscript under embargo until: 22nd March 2021

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DOI (Published version): 10.1016/j.jcjd.2020.03.003

Abstract

IntroductionIndividuals with type 1 diabetes try to manage the risk of exercise-induced hypoglycemia by means of pre-exercise/pre-meal bolus insulin dose reductions and/or consuming additional carbohydrates during exercise. Both strategies have proven to be effective in offsetting the occurrence aga...

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Published in: Canadian Journal of Diabetes
ISSN: 1499-2671
Published: Elsevier BV
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URI: https://cronfa.swan.ac.uk/Record/cronfa53869
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first_indexed 2020-03-27T13:35:19Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2020-11-03T10:21:36.3797800</datestamp><bib-version>v2</bib-version><id>53869</id><entry>2020-03-27</entry><title>Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis</title><swanseaauthors><author><sid>4fea3e19b39712dea1d051d317614572</sid><firstname>Olivia</firstname><surname>McCarthy</surname><name>Olivia McCarthy</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>f5da81cd18adfdedb2ccb845bddc12f7</sid><ORCID>0000-0002-6986-6449</ORCID><firstname>Richard</firstname><surname>Bracken</surname><name>Richard Bracken</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2020-03-27</date><deptcode>STSC</deptcode><abstract>IntroductionIndividuals with type 1 diabetes try to manage the risk of exercise-induced hypoglycemia by means of pre-exercise/pre-meal bolus insulin dose reductions and/or consuming additional carbohydrates during exercise. Both strategies have proven to be effective in offsetting the occurrence against hypoglycemia, it is unclear as to which one is more beneficial. Consequently, the aim of this study was to assess the efficacy of carbohydrate supplementation in comparison to bolus insulin dose reduction to prevent hypoglycemia during moderate-intensity exercise in individuals with type 1 diabetes.MethodsThis was a retrospective controlled analysis of two independent clinical trials. All participants performed a continuous moderate-intensity cycle ergometer exercise session for &#x223C;45 minutes. Two different therapy management groups and a control group were compared: Group (A) supplemented 15 &#x2013; 30 g carbohydrates at a glycemic threshold of 7.0 mmol/L during exercise, group (B) reduced their individual bolus insulin dose by 50% with their last meal prior to exercise and group (C) remained as a control.ResultsNo hypoglycemic events occurred in group A, which differed to each four events recorded in groups B (p = 0.02) and C (p = 0.02).ConclusionCarbohydrate supplementation was superior to bolus insulin reductions in the prevention of hypoglycemia during exercise in people with type 1 diabetes.</abstract><type>Journal Article</type><journal>Canadian Journal of Diabetes</journal><volume/><journalNumber/><paginationStart/><paginationEnd/><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1499-2671</issnPrint><issnElectronic/><keywords>Physical Exercise, Type 1 Diabetes, Insulin Therapy, Carbohydrates</keywords><publishedDay>0</publishedDay><publishedMonth>0</publishedMonth><publishedYear>0</publishedYear><publishedDate>0001-01-01</publishedDate><doi>10.1016/j.jcjd.2020.03.003</doi><url/><notes/><college>COLLEGE NANME</college><department>Sports Science</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><lastEdited>2020-11-03T10:21:36.3797800</lastEdited><Created>2020-03-27T08:32:55.7244975</Created><path><level id="1"/><level id="2"/></path><authors><author><firstname>Max L.</firstname><surname>Eckstein</surname><order>1</order></author><author><firstname>Olivia</firstname><surname>McCarthy</surname><order>2</order></author><author><firstname>Norbert J.</firstname><surname>Tripolt</surname><order>3</order></author><author><firstname>Alexander</firstname><surname>M&#xFC;ller</surname><order>4</order></author><author><firstname>Philipp</firstname><surname>Birnbaumer</surname><order>5</order></author><author><firstname>Peter N.</firstname><surname>Pferschy</surname><order>6</order></author><author><firstname>Peter</firstname><surname>Hofmann</surname><order>7</order></author><author><firstname>Richard</firstname><surname>Bracken</surname><orcid>0000-0002-6986-6449</orcid><order>8</order></author><author><firstname>Harald</firstname><surname>Sourij</surname><order>9</order></author><author><firstname>Othmar</firstname><surname>Moser</surname><order>10</order></author></authors><documents><document><filename>Under embargo</filename><originalFilename>Under embargo</originalFilename><uploaded>2020-03-27T08:34:39.8569653</uploaded><type>Output</type><contentLength>485696</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><action/><embargoDate>2021-03-22T00:00:00.0000000</embargoDate><documentNotes>&#xA9; 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2020-11-03T10:21:36.3797800 v2 53869 2020-03-27 Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis 4fea3e19b39712dea1d051d317614572 Olivia McCarthy Olivia McCarthy true false f5da81cd18adfdedb2ccb845bddc12f7 0000-0002-6986-6449 Richard Bracken Richard Bracken true false 2020-03-27 STSC IntroductionIndividuals with type 1 diabetes try to manage the risk of exercise-induced hypoglycemia by means of pre-exercise/pre-meal bolus insulin dose reductions and/or consuming additional carbohydrates during exercise. Both strategies have proven to be effective in offsetting the occurrence against hypoglycemia, it is unclear as to which one is more beneficial. Consequently, the aim of this study was to assess the efficacy of carbohydrate supplementation in comparison to bolus insulin dose reduction to prevent hypoglycemia during moderate-intensity exercise in individuals with type 1 diabetes.MethodsThis was a retrospective controlled analysis of two independent clinical trials. All participants performed a continuous moderate-intensity cycle ergometer exercise session for ∼45 minutes. Two different therapy management groups and a control group were compared: Group (A) supplemented 15 – 30 g carbohydrates at a glycemic threshold of 7.0 mmol/L during exercise, group (B) reduced their individual bolus insulin dose by 50% with their last meal prior to exercise and group (C) remained as a control.ResultsNo hypoglycemic events occurred in group A, which differed to each four events recorded in groups B (p = 0.02) and C (p = 0.02).ConclusionCarbohydrate supplementation was superior to bolus insulin reductions in the prevention of hypoglycemia during exercise in people with type 1 diabetes. Journal Article Canadian Journal of Diabetes Elsevier BV 1499-2671 Physical Exercise, Type 1 Diabetes, Insulin Therapy, Carbohydrates 0 0 0 0001-01-01 10.1016/j.jcjd.2020.03.003 COLLEGE NANME Sports Science COLLEGE CODE STSC Swansea University 2020-11-03T10:21:36.3797800 2020-03-27T08:32:55.7244975 Max L. Eckstein 1 Olivia McCarthy 2 Norbert J. Tripolt 3 Alexander Müller 4 Philipp Birnbaumer 5 Peter N. Pferschy 6 Peter Hofmann 7 Richard Bracken 0000-0002-6986-6449 8 Harald Sourij 9 Othmar Moser 10 Under embargo Under embargo 2020-03-27T08:34:39.8569653 Output 485696 application/pdf Accepted Manuscript true 2021-03-22T00:00:00.0000000 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. true eng
title Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis
spellingShingle Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis
Olivia, McCarthy
Richard, Bracken
title_short Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis
title_full Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis
title_fullStr Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis
title_full_unstemmed Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis
title_sort Efficacy of carbohydrate supplementation compared to bolus insulin dose reduction around exercise in adults with type 1 diabetes: a retrospective controlled analysis
author_id_str_mv 4fea3e19b39712dea1d051d317614572
f5da81cd18adfdedb2ccb845bddc12f7
author_id_fullname_str_mv 4fea3e19b39712dea1d051d317614572_***_Olivia, McCarthy
f5da81cd18adfdedb2ccb845bddc12f7_***_Richard, Bracken
author Olivia, McCarthy
Richard, Bracken
author2 Max L. Eckstein
Olivia McCarthy
Norbert J. Tripolt
Alexander Müller
Philipp Birnbaumer
Peter N. Pferschy
Peter Hofmann
Richard Bracken
Harald Sourij
Othmar Moser
format Journal article
container_title Canadian Journal of Diabetes
institution Swansea University
issn 1499-2671
doi_str_mv 10.1016/j.jcjd.2020.03.003
publisher Elsevier BV
document_store_str 0
active_str 0
description IntroductionIndividuals with type 1 diabetes try to manage the risk of exercise-induced hypoglycemia by means of pre-exercise/pre-meal bolus insulin dose reductions and/or consuming additional carbohydrates during exercise. Both strategies have proven to be effective in offsetting the occurrence against hypoglycemia, it is unclear as to which one is more beneficial. Consequently, the aim of this study was to assess the efficacy of carbohydrate supplementation in comparison to bolus insulin dose reduction to prevent hypoglycemia during moderate-intensity exercise in individuals with type 1 diabetes.MethodsThis was a retrospective controlled analysis of two independent clinical trials. All participants performed a continuous moderate-intensity cycle ergometer exercise session for ∼45 minutes. Two different therapy management groups and a control group were compared: Group (A) supplemented 15 – 30 g carbohydrates at a glycemic threshold of 7.0 mmol/L during exercise, group (B) reduced their individual bolus insulin dose by 50% with their last meal prior to exercise and group (C) remained as a control.ResultsNo hypoglycemic events occurred in group A, which differed to each four events recorded in groups B (p = 0.02) and C (p = 0.02).ConclusionCarbohydrate supplementation was superior to bolus insulin reductions in the prevention of hypoglycemia during exercise in people with type 1 diabetes.
published_date 0001-01-01T04:15:12Z
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score 10.780896

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