Journal article 455 views 94 downloads
A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide
Small, Volume: 16, Issue: 21, Start page: 2000486
Swansea University Author:
Paul Rees
-
PDF | Version of Record
Released under the terms of a Creative Commons Attribution-NonCommercial-NoDerivs License (CC-BY-NC-ND).
Download (2.17MB)
DOI (Published version): 10.1002/smll.202000486
Abstract
Human exposure to persistent, nonbiological nanoparticles and microparticles via the oral route is continuous and large scale (1012–1013 particles per day per adult in Europe). Whether this matters or not is unknown but confirmed health risks with airborne particle exposure warns against complacency...
Published in: | Small |
---|---|
ISSN: | 1613-6810 1613-6829 |
Published: |
Wiley
2020
|
Online Access: |
Check full text
|
URI: | https://cronfa.swan.ac.uk/Record/cronfa54222 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
first_indexed |
2020-05-14T19:08:28Z |
---|---|
last_indexed |
2020-06-04T19:09:37Z |
id |
cronfa54222 |
recordtype |
SURis |
fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2020-06-04T18:45:39.1599618</datestamp><bib-version>v2</bib-version><id>54222</id><entry>2020-05-14</entry><title>A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide</title><swanseaauthors><author><sid>537a2fe031a796a3bde99679ee8c24f5</sid><ORCID>0000-0002-7715-6914</ORCID><firstname>Paul</firstname><surname>Rees</surname><name>Paul Rees</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2020-05-14</date><deptcode>MEDE</deptcode><abstract>Human exposure to persistent, nonbiological nanoparticles and microparticles via the oral route is continuous and large scale (1012–1013 particles per day per adult in Europe). Whether this matters or not is unknown but confirmed health risks with airborne particle exposure warns against complacency. Murine models of oral exposure will help to identify risk but, to date, lack validation or relevance to humans. This work addresses that gap. It reports i) on a murine diet, modified with differing concentrations of the common dietary particle, food grade titanium dioxide (fgTiO2), an additive of polydisperse form that contains micro‐ and nano‐particles, ii) that these diets deliver particles to basal cells of intestinal lymphoid follicles, exactly as is reported as a “normal occurrence” in humans, iii) that confocal reflectance microscopy is the method of analytical choice to determine this, and iv) that food intake, weight gain, and Peyer's patch immune cell profiles, up to 18 weeks of feeding, do not differ between fgTiO2‐fed groups or controls. These findings afford a human‐relevant and validated oral dosing protocol for fgTiO2 risk assessment as well as provide a generalized platform for application to oral exposure studies with nano‐ and micro‐particles.</abstract><type>Journal Article</type><journal>Small</journal><volume>16</volume><journalNumber>21</journalNumber><paginationStart>2000486</paginationStart><publisher>Wiley</publisher><issnPrint>1613-6810</issnPrint><issnElectronic>1613-6829</issnElectronic><keywords/><publishedDay>26</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2020</publishedYear><publishedDate>2020-05-26</publishedDate><doi>10.1002/smll.202000486</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-06-04T18:45:39.1599618</lastEdited><Created>2020-05-14T13:37:36.8918253</Created><authors><author><firstname>Sebastian</firstname><surname>Riedle</surname><order>1</order></author><author><firstname>John W.</firstname><surname>Wills</surname><order>2</order></author><author><firstname>Michelle</firstname><surname>Miniter</surname><order>3</order></author><author><firstname>Don E.</firstname><surname>Otter</surname><order>4</order></author><author><firstname>Harjinder</firstname><surname>Singh</surname><order>5</order></author><author><firstname>Andy P.</firstname><surname>Brown</surname><order>6</order></author><author><firstname>Stuart</firstname><surname>Micklethwaite</surname><order>7</order></author><author><firstname>Paul</firstname><surname>Rees</surname><orcid>0000-0002-7715-6914</orcid><order>8</order></author><author><firstname>Ravin</firstname><surname>Jugdaohsingh</surname><order>9</order></author><author><firstname>Nicole C.</firstname><surname>Roy</surname><order>10</order></author><author><firstname>Rachel E.</firstname><surname>Hewitt</surname><order>11</order></author><author><firstname>Jonathan J.</firstname><surname>Powell</surname><order>12</order></author></authors><documents><document><filename>54222__17233__7175f29ae8954aa0bfe4897233674663.pdf</filename><originalFilename>54222.pdf</originalFilename><uploaded>2020-05-14T13:39:30.0960560</uploaded><type>Output</type><contentLength>2278990</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Released under the terms of a Creative Commons Attribution-NonCommercial-NoDerivs License (CC-BY-NC-ND).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>English</language><licence>http://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807> |
spelling |
2020-06-04T18:45:39.1599618 v2 54222 2020-05-14 A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide 537a2fe031a796a3bde99679ee8c24f5 0000-0002-7715-6914 Paul Rees Paul Rees true false 2020-05-14 MEDE Human exposure to persistent, nonbiological nanoparticles and microparticles via the oral route is continuous and large scale (1012–1013 particles per day per adult in Europe). Whether this matters or not is unknown but confirmed health risks with airborne particle exposure warns against complacency. Murine models of oral exposure will help to identify risk but, to date, lack validation or relevance to humans. This work addresses that gap. It reports i) on a murine diet, modified with differing concentrations of the common dietary particle, food grade titanium dioxide (fgTiO2), an additive of polydisperse form that contains micro‐ and nano‐particles, ii) that these diets deliver particles to basal cells of intestinal lymphoid follicles, exactly as is reported as a “normal occurrence” in humans, iii) that confocal reflectance microscopy is the method of analytical choice to determine this, and iv) that food intake, weight gain, and Peyer's patch immune cell profiles, up to 18 weeks of feeding, do not differ between fgTiO2‐fed groups or controls. These findings afford a human‐relevant and validated oral dosing protocol for fgTiO2 risk assessment as well as provide a generalized platform for application to oral exposure studies with nano‐ and micro‐particles. Journal Article Small 16 21 2000486 Wiley 1613-6810 1613-6829 26 5 2020 2020-05-26 10.1002/smll.202000486 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-06-04T18:45:39.1599618 2020-05-14T13:37:36.8918253 Sebastian Riedle 1 John W. Wills 2 Michelle Miniter 3 Don E. Otter 4 Harjinder Singh 5 Andy P. Brown 6 Stuart Micklethwaite 7 Paul Rees 0000-0002-7715-6914 8 Ravin Jugdaohsingh 9 Nicole C. Roy 10 Rachel E. Hewitt 11 Jonathan J. Powell 12 54222__17233__7175f29ae8954aa0bfe4897233674663.pdf 54222.pdf 2020-05-14T13:39:30.0960560 Output 2278990 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution-NonCommercial-NoDerivs License (CC-BY-NC-ND). true English http://creativecommons.org/licenses/by-nc-nd/4.0/ |
title |
A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide |
spellingShingle |
A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide Paul Rees |
title_short |
A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide |
title_full |
A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide |
title_fullStr |
A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide |
title_full_unstemmed |
A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide |
title_sort |
A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide |
author_id_str_mv |
537a2fe031a796a3bde99679ee8c24f5 |
author_id_fullname_str_mv |
537a2fe031a796a3bde99679ee8c24f5_***_Paul Rees |
author |
Paul Rees |
author2 |
Sebastian Riedle John W. Wills Michelle Miniter Don E. Otter Harjinder Singh Andy P. Brown Stuart Micklethwaite Paul Rees Ravin Jugdaohsingh Nicole C. Roy Rachel E. Hewitt Jonathan J. Powell |
format |
Journal article |
container_title |
Small |
container_volume |
16 |
container_issue |
21 |
container_start_page |
2000486 |
publishDate |
2020 |
institution |
Swansea University |
issn |
1613-6810 1613-6829 |
doi_str_mv |
10.1002/smll.202000486 |
publisher |
Wiley |
document_store_str |
1 |
active_str |
0 |
description |
Human exposure to persistent, nonbiological nanoparticles and microparticles via the oral route is continuous and large scale (1012–1013 particles per day per adult in Europe). Whether this matters or not is unknown but confirmed health risks with airborne particle exposure warns against complacency. Murine models of oral exposure will help to identify risk but, to date, lack validation or relevance to humans. This work addresses that gap. It reports i) on a murine diet, modified with differing concentrations of the common dietary particle, food grade titanium dioxide (fgTiO2), an additive of polydisperse form that contains micro‐ and nano‐particles, ii) that these diets deliver particles to basal cells of intestinal lymphoid follicles, exactly as is reported as a “normal occurrence” in humans, iii) that confocal reflectance microscopy is the method of analytical choice to determine this, and iv) that food intake, weight gain, and Peyer's patch immune cell profiles, up to 18 weeks of feeding, do not differ between fgTiO2‐fed groups or controls. These findings afford a human‐relevant and validated oral dosing protocol for fgTiO2 risk assessment as well as provide a generalized platform for application to oral exposure studies with nano‐ and micro‐particles. |
published_date |
2020-05-26T04:07:37Z |
_version_ |
1763753546114662400 |
score |
11.021648 |