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Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood

Niusha Shishegari, Abbas Sabahi, Faranak Manteghi, Ali Ghaffarinejad, Zari Tehrani Orcid Logo

Journal of Electroanalytical Chemistry, Volume: 871, Start page: 114285

Swansea University Author: Zari Tehrani Orcid Logo

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DOI (Published version): 10.1016/j.jelechem.2020.114285

Abstract

Herein, a novel highly sensitive and selective non-enzymatic glucose sensor was developed. This sensor was prepared with a one-step electrodeposition process, which means that the palladium nanoparticles and NiAl layered double hydroxide were electrosynthesized simultaneously (Pd-NiAl-LDH) on a grap...

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Published in: Journal of Electroanalytical Chemistry
ISSN: 1572-6657
Published: Elsevier BV 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa54381
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spelling 2020-07-23T13:12:32.8594156 v2 54381 2020-06-04 Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood fd8e614b01086804c80fbafa6fa6aaf5 0000-0002-5069-7921 Zari Tehrani Zari Tehrani true false 2020-06-04 CHEG Herein, a novel highly sensitive and selective non-enzymatic glucose sensor was developed. This sensor was prepared with a one-step electrodeposition process, which means that the palladium nanoparticles and NiAl layered double hydroxide were electrosynthesized simultaneously (Pd-NiAl-LDH) on a graphite sheet electrode (GS) covered by nitrogen-doped functionalized graphene (NFG). The sensing performance was investigated by linear sweep voltammetry (LSV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry (CA) techniques. The results revealed that the one-step electrodeposition of Pd-NiAl-LDH nanocomposite on NFG provided a large surface area containing Ni and Pd electroactive centers and enhanced the electron transfer. This resulted in a remarkable effect on signal amplification toward glucose oxidation, with a wide linear range from 500 nM to 10 mM, an acceptable sensitivity of 315.46 μA. cm−2. dec−1 and a low detection limit of 234 nM based on a signal to noise ratio of 3. The relative standard deviation (RSD%) in all detection tests was lower than 5% and also the performance of fabricated GS/NFG/Pd-NiAl-LDH electrode which investigated in human real samples including serum, plasma and blood was acceptable, indicating the ability of the fabricated sensor in biological and clinical applications. Journal Article Journal of Electroanalytical Chemistry 871 114285 Elsevier BV 1572-6657 One-step electrodeposition, Layered double hydroxide, Electrochemical non-enzymatic sensor, Glucose 15 8 2020 2020-08-15 10.1016/j.jelechem.2020.114285 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2020-07-23T13:12:32.8594156 2020-06-04T10:08:10.2237261 Niusha Shishegari 1 Abbas Sabahi 2 Faranak Manteghi 3 Ali Ghaffarinejad 4 Zari Tehrani 0000-0002-5069-7921 5 54381__17428__e904efafeaa34e268e47672f66f1a235.pdf 54381.pdf 2020-06-05T09:18:35.2847037 Output 2528146 application/pdf Accepted Manuscript true 2021-05-31T00:00:00.0000000 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ false
title Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood
spellingShingle Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood
Zari Tehrani
title_short Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood
title_full Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood
title_fullStr Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood
title_full_unstemmed Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood
title_sort Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood
author_id_str_mv fd8e614b01086804c80fbafa6fa6aaf5
author_id_fullname_str_mv fd8e614b01086804c80fbafa6fa6aaf5_***_Zari Tehrani
author Zari Tehrani
author2 Niusha Shishegari
Abbas Sabahi
Faranak Manteghi
Ali Ghaffarinejad
Zari Tehrani
format Journal article
container_title Journal of Electroanalytical Chemistry
container_volume 871
container_start_page 114285
publishDate 2020
institution Swansea University
issn 1572-6657
doi_str_mv 10.1016/j.jelechem.2020.114285
publisher Elsevier BV
document_store_str 1
active_str 0
description Herein, a novel highly sensitive and selective non-enzymatic glucose sensor was developed. This sensor was prepared with a one-step electrodeposition process, which means that the palladium nanoparticles and NiAl layered double hydroxide were electrosynthesized simultaneously (Pd-NiAl-LDH) on a graphite sheet electrode (GS) covered by nitrogen-doped functionalized graphene (NFG). The sensing performance was investigated by linear sweep voltammetry (LSV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry (CA) techniques. The results revealed that the one-step electrodeposition of Pd-NiAl-LDH nanocomposite on NFG provided a large surface area containing Ni and Pd electroactive centers and enhanced the electron transfer. This resulted in a remarkable effect on signal amplification toward glucose oxidation, with a wide linear range from 500 nM to 10 mM, an acceptable sensitivity of 315.46 μA. cm−2. dec−1 and a low detection limit of 234 nM based on a signal to noise ratio of 3. The relative standard deviation (RSD%) in all detection tests was lower than 5% and also the performance of fabricated GS/NFG/Pd-NiAl-LDH electrode which investigated in human real samples including serum, plasma and blood was acceptable, indicating the ability of the fabricated sensor in biological and clinical applications.
published_date 2020-08-15T04:07:53Z
_version_ 1763753562698940416
score 10.997933

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