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Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial

O. Nicholas, C. Bowden, A. Selby, Owen Bodger Orcid Logo, Paul Lewis, R. Webster, G. Radhakrishna, G. Jones, M. Hawkins, S. Mukherjee, T. Crosby, S. Gwynne

Clinical Oncology, Volume: 32, Issue: 12

Swansea University Authors: Owen Bodger Orcid Logo, Paul Lewis

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Abstract

Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4...

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Published in: Clinical Oncology
ISSN: 0936-6555
Published: Elsevier BV 2020
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa54566
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Abstract: Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4D-CT into the radiotherapy planning. Using NeoSCOPE 4D-CT cases, we undertook a dosimetric comparison study of 3D-CT versus 4D-CT plans comparing target volume coverage and dose to organs at risk. We used established normal tissue complication probability (NTCP) models to evaluate the potential toxicity reduction of using 4D-CT plans in oesophageal cancer. Our work shows that incorporating 4D-CT into treatment planning may significantly reduce the toxicity burden from this treatment.
Keywords: 4D-CT planning; NTCP; oesophageal cancer; organs at risk; postoperative toxicity; radiotherapy
College: Faculty of Medicine, Health and Life Sciences
Issue: 12