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Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial / O. Nicholas; C. Bowden; A. Selby; Owen Bodger; Paul Lewis; R. Webster; G. Radhakrishna; G. Jones; M. Hawkins; S. Mukherjee; T. Crosby; S. Gwynne

Clinical Oncology

Swansea University Authors: Owen, Bodger, Paul, Lewis

  • Accepted Manuscript under embargo until: 19th July 2021

Abstract

Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4...

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Published in: Clinical Oncology
ISSN: 0936-6555
Published: Elsevier BV
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa54566
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Abstract: Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4D-CT into the radiotherapy planning. Using NeoSCOPE 4D-CT cases, we undertook a dosimetric comparison study of 3D-CT versus 4D-CT plans comparing target volume coverage and dose to organs at risk. We used established normal tissue complication probability (NTCP) models to evaluate the potential toxicity reduction of using 4D-CT plans in oesophageal cancer. Our work shows that incorporating 4D-CT into treatment planning may significantly reduce the toxicity burden from this treatment.
Keywords: 4D-CT planning; NTCP; oesophageal cancer; organs at risk; postoperative toxicity; radiotherapy