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Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial / O. Nicholas, C. Bowden, A. Selby, Owen Bodger, Paul Lewis, R. Webster, G. Radhakrishna, G. Jones, M. Hawkins, S. Mukherjee, T. Crosby, S. Gwynne

Clinical Oncology, Volume: 32, Issue: 12

Swansea University Authors: Owen Bodger, Paul Lewis

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Abstract

Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4...

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Published in: Clinical Oncology
ISSN: 0936-6555
Published: Elsevier BV
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa54566
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Abstract: Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4D-CT into the radiotherapy planning. Using NeoSCOPE 4D-CT cases, we undertook a dosimetric comparison study of 3D-CT versus 4D-CT plans comparing target volume coverage and dose to organs at risk. We used established normal tissue complication probability (NTCP) models to evaluate the potential toxicity reduction of using 4D-CT plans in oesophageal cancer. Our work shows that incorporating 4D-CT into treatment planning may significantly reduce the toxicity burden from this treatment.
Keywords: 4D-CT planning; NTCP; oesophageal cancer; organs at risk; postoperative toxicity; radiotherapy
Issue: 12