Journal article 964 views 243 downloads
Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial
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Paul Lewis,
R. Webster,
G. Radhakrishna,
G. Jones,
M. Hawkins,
S. Mukherjee,
T. Crosby,
S. Gwynne
Clinical Oncology, Volume: 32, Issue: 12
Swansea University Authors:
Owen Bodger , Paul Lewis
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DOI (Published version): 10.1016/j.clon.2020.06.022
Abstract
Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4...
| Published in: | Clinical Oncology |
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| ISSN: | 0936-6555 |
| Published: |
Elsevier BV
2020
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa54566 |
| Abstract: |
Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4D-CT into the radiotherapy planning. Using NeoSCOPE 4D-CT cases, we undertook a dosimetric comparison study of 3D-CT versus 4D-CT plans comparing target volume coverage and dose to organs at risk. We used established normal tissue complication probability (NTCP) models to evaluate the potential toxicity reduction of using 4D-CT plans in oesophageal cancer. Our work shows that incorporating 4D-CT into treatment planning may significantly reduce the toxicity burden from this treatment. |
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| Keywords: |
4D-CT planning; NTCP; oesophageal cancer; organs at risk; postoperative toxicity; radiotherapy |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
12 |