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Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)

Chedly Tizaoui Orcid Logo

Ozone: Science & Engineering, Volume: 42, Issue: 5, Pages: 378 - 385

Swansea University Author: Chedly Tizaoui Orcid Logo

Abstract

Currently, no medicine has demonstrated efficacy in treating the ongoing pandemic COVID-19 caused by SARS-CoV-2 virus. Being a potent oxidant, ozone is lethal against most bacteria and viruses found in water, or on surfaces and aerosols. Ozone has also been successfully used to treat several viral d...

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Published in: Ozone: Science & Engineering
ISSN: 0191-9512 1547-6545
Published: Informa UK Limited 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa54867
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spelling 2021-12-01T13:34:19.6771074 v2 54867 2020-08-04 Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2) 4b34a0286d3c0b0b081518fa6987031d 0000-0003-2159-7881 Chedly Tizaoui Chedly Tizaoui true false 2020-08-04 CHEG Currently, no medicine has demonstrated efficacy in treating the ongoing pandemic COVID-19 caused by SARS-CoV-2 virus. Being a potent oxidant, ozone is lethal against most bacteria and viruses found in water, or on surfaces and aerosols. Ozone has also been successfully used to treat several viral diseases such as Ebola and HIV Hepatitis B and C. Using molecular modeling, this study evaluated the reactivity of ozone toward representative key molecules in the structure of SARS-CoV-2. The results show that ozone is able to attack the proteins and lipids of the virus’s spikes and envelope, particularly the amino acids tryptophan, methionine and cysteine, and the fatty acids, arachidonic acid, linoleic acid, and oleic acid. Ozone also attacks the N-glycopeptides of the spike protein subunits 1 and 2, though at lower reactivity. Disruption of the structure of SARS-CoV-2 could inactivate the virus, suggesting that ozone could be an effective oxidant against COVID-19 virus. If incorrectly applied, ozone is toxic and contact with the respiratory tract must be avoided. Journal Article Ozone: Science & Engineering 42 5 378 385 Informa UK Limited 0191-9512 1547-6545 Ozone, SARS-CoV-2, COVID-19, coronavirus, severe acute respiratory syndrome 2 9 2020 2020-09-02 10.1080/01919512.2020.1795614 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2021-12-01T13:34:19.6771074 2020-08-04T14:11:48.8935599 College of Engineering Engineering Chedly Tizaoui 0000-0003-2159-7881 1 54867__18261__ce1b0be903a746678dfa37bf5d37c33e.pdf 54867.pdf 2020-09-28T10:12:17.4521339 Output 810682 application/pdf Accepted Manuscript true 2021-07-27T00:00:00.0000000 true English
title Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
spellingShingle Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
Chedly Tizaoui
title_short Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
title_full Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
title_fullStr Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
title_full_unstemmed Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
title_sort Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
author_id_str_mv 4b34a0286d3c0b0b081518fa6987031d
author_id_fullname_str_mv 4b34a0286d3c0b0b081518fa6987031d_***_Chedly Tizaoui
author Chedly Tizaoui
author2 Chedly Tizaoui
format Journal article
container_title Ozone: Science & Engineering
container_volume 42
container_issue 5
container_start_page 378
publishDate 2020
institution Swansea University
issn 0191-9512
1547-6545
doi_str_mv 10.1080/01919512.2020.1795614
publisher Informa UK Limited
college_str College of Engineering
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hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
document_store_str 1
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description Currently, no medicine has demonstrated efficacy in treating the ongoing pandemic COVID-19 caused by SARS-CoV-2 virus. Being a potent oxidant, ozone is lethal against most bacteria and viruses found in water, or on surfaces and aerosols. Ozone has also been successfully used to treat several viral diseases such as Ebola and HIV Hepatitis B and C. Using molecular modeling, this study evaluated the reactivity of ozone toward representative key molecules in the structure of SARS-CoV-2. The results show that ozone is able to attack the proteins and lipids of the virus’s spikes and envelope, particularly the amino acids tryptophan, methionine and cysteine, and the fatty acids, arachidonic acid, linoleic acid, and oleic acid. Ozone also attacks the N-glycopeptides of the spike protein subunits 1 and 2, though at lower reactivity. Disruption of the structure of SARS-CoV-2 could inactivate the virus, suggesting that ozone could be an effective oxidant against COVID-19 virus. If incorrectly applied, ozone is toxic and contact with the respiratory tract must be avoided.
published_date 2020-09-02T04:09:40Z
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