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Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study

Othmar Moser, Marlene Dietrich, Olivia McCarthy, Richard Bracken Orcid Logo, Max L. Eckstein

Diabetes, Obesity and Metabolism, Volume: 22, Issue: 10, Pages: 1714 - 1721

Swansea University Authors: Olivia McCarthy, Richard Bracken Orcid Logo

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DOI (Published version): 10.1111/dom.14083

Abstract

AimsTo assess insulin therapy, macronutrient intake and glycaemia in professional cyclists with type 1 diabetes (T1D) over a 5‐day Union Cycliste Internationale road‐cycle race.Material and methodsIn this prospective observational study, seven professional cyclists with T1D (age 28 ± 4 years, body m...

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Published in: Diabetes, Obesity and Metabolism
ISSN: 1462-8902 1463-1326
Published: Wiley 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa55190
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spelling 2020-11-05T14:25:25.4522648 v2 55190 2020-09-16 Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study 4fea3e19b39712dea1d051d317614572 Olivia McCarthy Olivia McCarthy true false f5da81cd18adfdedb2ccb845bddc12f7 0000-0002-6986-6449 Richard Bracken Richard Bracken true false 2020-09-16 STSC AimsTo assess insulin therapy, macronutrient intake and glycaemia in professional cyclists with type 1 diabetes (T1D) over a 5‐day Union Cycliste Internationale road‐cycle race.Material and methodsIn this prospective observational study, seven professional cyclists with T1D (age 28 ± 4 years, body mass index 20.9 ± 0.9 kg/m2, glycated haemoglobin concentration 56 ± 7 mmol/mol [7.3% ± 0.6%]) were monitored during a five‐stage professional road cycling race. Real‐time continuous glucose monitoring (rtCGM) data, smart insulin pen dose data and macronutrient intake were assessed by means of repeated‐measure one‐way ANOVA and post hoc testing. Associations between exercise physiological markers and rtCGM data, insulin doses and macronutrient intake were assessed via linear regression modelling (P ≤ 0.05).ResultsBolus insulin dose was significantly reduced over the 5‐day period (P = 0.03), while carbohydrate intake (P = 0.24) and basal insulin doses remained unchanged (P = 0.64). A higher mean previous‐day race intensity was associated with a lower mean sensor glucose level (P = 0.03), less time above range level 2 (>13.9 mmol/L [250 mg/dL]; P = 0.05) and lower doses of bolus insulin (P = 0.04) on the subsequent day. No significant associations were found for any other glycaemic range and glycaemic variability (P > 0.05).ConclusionsThis is the first study to demonstrate the influence of previous‐day race intensity on subsequent bolus insulin dose requirements in professional cyclists with T1D. These data may help inform therapeutic strategies to ensure safe exercise performance. Journal Article Diabetes, Obesity and Metabolism 22 10 1714 1721 Wiley 1462-8902 1463-1326 1 10 2020 2020-10-01 10.1111/dom.14083 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2020-11-05T14:25:25.4522648 2020-09-16T15:56:37.8163787 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Othmar Moser 1 Marlene Dietrich 2 Olivia McCarthy 3 Richard Bracken 0000-0002-6986-6449 4 Max L. Eckstein 5 55190__18180__abe3f4b273c84801a1ac57af3aa02de7.pdf 55190.pdf 2020-09-16T15:58:48.2466618 Output 1413362 application/pdf Version of Record true © 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License true eng http://creativecommons.org/licenses/by-nc/4.0/
title Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study
spellingShingle Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study
Olivia McCarthy
Richard Bracken
title_short Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study
title_full Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study
title_fullStr Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study
title_full_unstemmed Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study
title_sort Bolus insulin dose depends on previous‐day race intensity during 5 days of professional road‐cycle racing in athletes with type 1 diabetes: A prospective observational study
author_id_str_mv 4fea3e19b39712dea1d051d317614572
f5da81cd18adfdedb2ccb845bddc12f7
author_id_fullname_str_mv 4fea3e19b39712dea1d051d317614572_***_Olivia McCarthy
f5da81cd18adfdedb2ccb845bddc12f7_***_Richard Bracken
author Olivia McCarthy
Richard Bracken
author2 Othmar Moser
Marlene Dietrich
Olivia McCarthy
Richard Bracken
Max L. Eckstein
format Journal article
container_title Diabetes, Obesity and Metabolism
container_volume 22
container_issue 10
container_start_page 1714
publishDate 2020
institution Swansea University
issn 1462-8902
1463-1326
doi_str_mv 10.1111/dom.14083
publisher Wiley
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
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description AimsTo assess insulin therapy, macronutrient intake and glycaemia in professional cyclists with type 1 diabetes (T1D) over a 5‐day Union Cycliste Internationale road‐cycle race.Material and methodsIn this prospective observational study, seven professional cyclists with T1D (age 28 ± 4 years, body mass index 20.9 ± 0.9 kg/m2, glycated haemoglobin concentration 56 ± 7 mmol/mol [7.3% ± 0.6%]) were monitored during a five‐stage professional road cycling race. Real‐time continuous glucose monitoring (rtCGM) data, smart insulin pen dose data and macronutrient intake were assessed by means of repeated‐measure one‐way ANOVA and post hoc testing. Associations between exercise physiological markers and rtCGM data, insulin doses and macronutrient intake were assessed via linear regression modelling (P ≤ 0.05).ResultsBolus insulin dose was significantly reduced over the 5‐day period (P = 0.03), while carbohydrate intake (P = 0.24) and basal insulin doses remained unchanged (P = 0.64). A higher mean previous‐day race intensity was associated with a lower mean sensor glucose level (P = 0.03), less time above range level 2 (>13.9 mmol/L [250 mg/dL]; P = 0.05) and lower doses of bolus insulin (P = 0.04) on the subsequent day. No significant associations were found for any other glycaemic range and glycaemic variability (P > 0.05).ConclusionsThis is the first study to demonstrate the influence of previous‐day race intensity on subsequent bolus insulin dose requirements in professional cyclists with T1D. These data may help inform therapeutic strategies to ensure safe exercise performance.
published_date 2020-10-01T04:09:13Z
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