No Cover Image

Journal article 125 views 20 downloads

The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis / Ruth Davies, Jessica Williams, Katie Sime, Hyun-Sun Jin, Charlotte Thompson, Lauren Jordan, Derek Lang, Julian P Halcox, Elizabeth Ellins, Gareth W Jones, Simon A Jones, Stefan Rose-John, Anwen Williams, Ernest Choy, Julian Halcox, Libby Ellins

Rheumatology, Volume: 60, Issue: 6, Pages: 2852 - 2861

Swansea University Authors: Julian Halcox, Libby Ellins

  • 55470.pdf

    PDF | Version of Record

    ©The Author(s) 2020. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License

    Download (460.1KB)

Check full text

DOI (Published version): 10.1093/rheumatology/keaa725

Abstract

Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the...

Full description

Published in: Rheumatology
ISSN: 1462-0324 1462-0332
Published: Oxford University Press (OUP) 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa55470
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the two modes of IL-6 signalling, trans-signalling is pro-inflammatory whereas classical signalling is linked with inflammation resolution. This study examines the role of IL-6 trans-signalling in CVD in a mouse model and patients with RA.
Keywords: RA, inflammation, cardiovascular diseases, experimental arthritis
College: Swansea University Medical School
Issue: 6
Start Page: 2852
End Page: 2861

Similar Items