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The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis / Ruth Davies, Jessica Williams, Katie Sime, Hyun-Sun Jin, Charlotte Thompson, Lauren Jordan, Derek Lang, Julian P Halcox, Elizabeth Ellins, Gareth W Jones, Simon A Jones, Stefan Rose-John, Anwen Williams, Ernest Choy, Julian Halcox, Libby Ellins

Rheumatology, Volume: 60, Issue: 6, Pages: 2852 - 2861

Swansea University Authors: Julian Halcox, Libby Ellins

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Abstract

Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the...

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Published in: Rheumatology
ISSN: 1462-0324 1462-0332
Published: Oxford University Press (OUP) 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa55470
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Abstract: Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the two modes of IL-6 signalling, trans-signalling is pro-inflammatory whereas classical signalling is linked with inflammation resolution. This study examines the role of IL-6 trans-signalling in CVD in a mouse model and patients with RA.
Keywords: RA, inflammation, cardiovascular diseases, experimental arthritis
College: Swansea University Medical School
Issue: 6
Start Page: 2852
End Page: 2861