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The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis / Ruth Davies; Jessica Williams; Katie Sime; Hyun-Sun Jin; Charlotte Thompson; Lauren Jordan; Derek Lang; Julian P Halcox; Elizabeth Ellins; Gareth W Jones; Simon A Jones; Stefan Rose-John; Anwen Williams; Ernest Choy; Julian Halcox; Libby Ellins
Rheumatology, Volume: 60, Issue: 6, Pages: 2852 - 2861
Swansea University Authors: Julian, Halcox, Libby, Ellins
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DOI (Published version): 10.1093/rheumatology/keaa725
Abstract
Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the...
| Published in: | Rheumatology |
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| ISSN: | 1462-0324 1462-0332 |
| Published: |
Oxford University Press (OUP)
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa55470 |
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| Abstract: |
Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the two modes of IL-6 signalling, trans-signalling is pro-inflammatory whereas classical signalling is linked with inflammation resolution. This study examines the role of IL-6 trans-signalling in CVD in a mouse model and patients with RA. |
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| Keywords: |
RA, inflammation, cardiovascular diseases, experimental arthritis |
| College: |
Swansea University Medical School |
| Issue: |
6 |
| Start Page: |
2852 |
| End Page: |
2861 |