Journal article 639 views 107 downloads
Towards enabling a cardiovascular digital twin for human systemic circulation using inverse analysis
,
Perumal Nithiarasu
Biomechanics and Modeling in Mechanobiology, Volume: 20, Issue: 2, Pages: 449 - 465
Swansea University Authors:
Neeraj Kavan Chakshu, Igor Sazonov , Perumal Nithiarasu
-
PDF | Version of Record
© 2020 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 (CC BY) License
Download (1.92MB)
DOI (Published version): 10.1007/s10237-020-01393-6
Abstract
An exponential rise in patient data provides an excellent opportunity to improve the existing health care infrastructure. In the present work, a method to enable cardiovascular digital twin is proposed using inverse analysis. Conventionally, accurate analytical solutions for inverse analysis in line...
| Published in: | Biomechanics and Modeling in Mechanobiology |
|---|---|
| ISSN: | 1617-7959 1617-7940 |
| Published: |
Springer Science and Business Media LLC
2021
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa55503 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract: |
An exponential rise in patient data provides an excellent opportunity to improve the existing health care infrastructure. In the present work, a method to enable cardiovascular digital twin is proposed using inverse analysis. Conventionally, accurate analytical solutions for inverse analysis in linear problems have been proposed and used. However, these methods fail or are not efficient for nonlinear systems, such as blood flow in the cardiovascular system (systemic circulation) that involves high degree of nonlinearity. To address this, a methodology for inverse analysis using recurrent neural network for the cardiovascular system is proposed in this work, using a virtual patient database. Blood pressure waveforms in various vessels of the body are inversely calculated with the help of long short-term memory (LSTM) cells by inputting pressure waveforms from three non-invasively accessible blood vessels (carotid, femoral and brachial arteries). The inverse analysis system built this way is applied to the detection of abdominal aortic aneurysm (AAA) and its severity using neural networks. |
|---|---|
| Keywords: |
Inverse analysis, Deep learning, Digital twin technology, Systemic circulation, Blood flow, Aneurysm detection |
| College: |
Faculty of Science and Engineering |
| Issue: |
2 |
| Start Page: |
449 |
| End Page: |
465 |