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Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes

Zoe Marshall, Kelly Mackintosh Orcid Logo, Michael Lewis, Libby Ellins Orcid Logo, Melitta McNarry Orcid Logo

Pediatric Diabetes, Volume: 22, Issue: 2, Pages: 320 - 328

Swansea University Authors: Zoe Marshall , Kelly Mackintosh Orcid Logo, Michael Lewis , Libby Ellins Orcid Logo, Melitta McNarry Orcid Logo

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DOI (Published version): 10.1111/pedi.13159

Abstract

ObjectiveLittle is known about the role of physical activity accumulation in cardiovascular disease risk for children with type 1 diabetes. Improved insight to identify factors of influence in key health outcomes could be provided by considering the entire physical activity profile.MethodsPulse wave...

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Published in: Pediatric Diabetes
ISSN: 1399-543X 1399-5448
Published: Wiley 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa55673
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Improved insight to identify factors of influence in key health outcomes could be provided by considering the entire physical activity profile.MethodsPulse wave velocity (PWV), augmentation index and heart rate variability (HRV) were assessed cross&#x2010;sectionally in children with (n = 29, 12.1&#x2009;&#xB1;&#x2009;2.1&#x2009;years) and without (n = 19, 12.1&#x2009;&#xB1;&#x2009;2.1&#x2009;years) type 1 diabetes. Time spent sedentary and in each physical activity intensity, intensity gradient and average acceleration were derived from seven consecutive days of monitoring with wrist&#x2010;worn accelerometry. Comparison between groups and influence of physical activity accumulation on cardiovascular metrics were explored with linear mixed models.ResultsDiabetic children demonstrated a higher PWV and a greater volume of light physical activity (p&#x2009;&lt;&#x2009;0.01), a more negative intensity gradient (p&#x2009;&lt;&#x2009;0.01), a lower average acceleration and less time in bouted moderate&#x2010;to&#x2010;vigorous physical activity (MVPA; p&#x2009;&lt;&#x2009;0.05). Overall, intensity gradient was strongly correlated with average acceleration, MVPA and bouted MVPA (r2 = 0.89, r2 = 0.80, r2 = 0.79, respectively; all p&#x2009;&lt;&#x2009;0.05), while average acceleration was correlated with MVPA and bouted MVPA (r2 = 0.85, r2 = 0.83, respectively; p&#x2009;&lt;&#x2009;0.05). Accounting for disease status, intensity gradient and average acceleration were significant predictors of HRV indices (p&#x2009;&lt;&#x2009;0.05) and PWV (p&#x2009;&lt;&#x2009;0.01, p&#x2009;&lt;&#x2009;0.05, respectively).ConclusionOverall, MVPA was most associated with central stiffness, highlighting the importance of meeting activity guidelines. Diabetic children demonstrated poorer cardiovascular health than their counterparts, likely attributable to a lower intensity and physical activity volume, identifying physical activity intensity as a key target for future interventions.</abstract><type>Journal Article</type><journal>Pediatric Diabetes</journal><volume>22</volume><journalNumber>2</journalNumber><paginationStart>320</paginationStart><paginationEnd>328</paginationEnd><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1399-543X</issnPrint><issnElectronic>1399-5448</issnElectronic><keywords>arterial stiffness; average acceleration; heart rate variability; intensity gradient; pulse wave velocity</keywords><publishedDay>1</publishedDay><publishedMonth>3</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-03-01</publishedDate><doi>10.1111/pedi.13159</doi><url/><notes/><college>COLLEGE NANME</college><department>Science and Engineering - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGSEN</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2021-04-28T16:39:10.8805688</lastEdited><Created>2020-11-16T15:19:58.6142676</Created><path><level id="1">College of Engineering</level><level id="2">Sports Science</level></path><authors><author><firstname>Zoe</firstname><surname>Marshall</surname><order>1</order></author><author><firstname>Kelly</firstname><surname>Mackintosh</surname><orcid>0000-0003-0355-6357</orcid><order>2</order></author><author><firstname>Michael</firstname><surname>Lewis</surname><order>3</order></author><author><firstname>Libby</firstname><surname>Ellins</surname><orcid>0000-0001-5164-6416</orcid><order>4</order></author><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>5</order></author></authors><documents><document><filename>55673__18670__0740bf30abf34eafba48f834241e5db6.pdf</filename><originalFilename>55673.pdf</originalFilename><uploaded>2020-11-16T15:21:40.1503831</uploaded><type>Output</type><contentLength>775505</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2021-11-20T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2021-04-28T16:39:10.8805688 v2 55673 2020-11-16 Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes c5ddb01098ac73242456f06a6b6ed7e2 Zoe Marshall Zoe Marshall true false bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false b59c8f5c056bac7e6995385f22ad1639 Michael Lewis Michael Lewis true false 553ce2abe05a6396e7dd6eadb6b90a6d 0000-0001-5164-6416 Libby Ellins Libby Ellins true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 2020-11-16 FGSEN ObjectiveLittle is known about the role of physical activity accumulation in cardiovascular disease risk for children with type 1 diabetes. Improved insight to identify factors of influence in key health outcomes could be provided by considering the entire physical activity profile.MethodsPulse wave velocity (PWV), augmentation index and heart rate variability (HRV) were assessed cross‐sectionally in children with (n = 29, 12.1 ± 2.1 years) and without (n = 19, 12.1 ± 2.1 years) type 1 diabetes. Time spent sedentary and in each physical activity intensity, intensity gradient and average acceleration were derived from seven consecutive days of monitoring with wrist‐worn accelerometry. Comparison between groups and influence of physical activity accumulation on cardiovascular metrics were explored with linear mixed models.ResultsDiabetic children demonstrated a higher PWV and a greater volume of light physical activity (p < 0.01), a more negative intensity gradient (p < 0.01), a lower average acceleration and less time in bouted moderate‐to‐vigorous physical activity (MVPA; p < 0.05). Overall, intensity gradient was strongly correlated with average acceleration, MVPA and bouted MVPA (r2 = 0.89, r2 = 0.80, r2 = 0.79, respectively; all p < 0.05), while average acceleration was correlated with MVPA and bouted MVPA (r2 = 0.85, r2 = 0.83, respectively; p < 0.05). Accounting for disease status, intensity gradient and average acceleration were significant predictors of HRV indices (p < 0.05) and PWV (p < 0.01, p < 0.05, respectively).ConclusionOverall, MVPA was most associated with central stiffness, highlighting the importance of meeting activity guidelines. Diabetic children demonstrated poorer cardiovascular health than their counterparts, likely attributable to a lower intensity and physical activity volume, identifying physical activity intensity as a key target for future interventions. Journal Article Pediatric Diabetes 22 2 320 328 Wiley 1399-543X 1399-5448 arterial stiffness; average acceleration; heart rate variability; intensity gradient; pulse wave velocity 1 3 2021 2021-03-01 10.1111/pedi.13159 COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University 2021-04-28T16:39:10.8805688 2020-11-16T15:19:58.6142676 College of Engineering Sports Science Zoe Marshall 1 Kelly Mackintosh 0000-0003-0355-6357 2 Michael Lewis 3 Libby Ellins 0000-0001-5164-6416 4 Melitta McNarry 0000-0003-0813-7477 5 55673__18670__0740bf30abf34eafba48f834241e5db6.pdf 55673.pdf 2020-11-16T15:21:40.1503831 Output 775505 application/pdf Accepted Manuscript true 2021-11-20T00:00:00.0000000 true eng
title Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes
spellingShingle Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes
Zoe, Marshall
Kelly, Mackintosh
Michael, Lewis
Libby, Ellins
Melitta, McNarry
title_short Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes
title_full Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes
title_fullStr Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes
title_full_unstemmed Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes
title_sort Association of physical activity metrics with indicators of cardiovascular function and control in children with and without type 1 diabetes
author_id_str_mv c5ddb01098ac73242456f06a6b6ed7e2
bdb20e3f31bcccf95c7bc116070c4214
b59c8f5c056bac7e6995385f22ad1639
553ce2abe05a6396e7dd6eadb6b90a6d
062f5697ff59f004bc8c713955988398
author_id_fullname_str_mv c5ddb01098ac73242456f06a6b6ed7e2_***_Zoe, Marshall_***_
bdb20e3f31bcccf95c7bc116070c4214_***_Kelly, Mackintosh_***_0000-0003-0355-6357
b59c8f5c056bac7e6995385f22ad1639_***_Michael, Lewis_***_
553ce2abe05a6396e7dd6eadb6b90a6d_***_Libby, Ellins_***_0000-0001-5164-6416
062f5697ff59f004bc8c713955988398_***_Melitta, McNarry_***_0000-0003-0813-7477
author Zoe, Marshall
Kelly, Mackintosh
Michael, Lewis
Libby, Ellins
Melitta, McNarry
author2 Zoe Marshall
Kelly Mackintosh
Michael Lewis
Libby Ellins
Melitta McNarry
format Journal article
container_title Pediatric Diabetes
container_volume 22
container_issue 2
container_start_page 320
publishDate 2021
institution Swansea University
issn 1399-543X
1399-5448
doi_str_mv 10.1111/pedi.13159
publisher Wiley
college_str College of Engineering
hierarchytype
hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Sports Science{{{_:::_}}}College of Engineering{{{_:::_}}}Sports Science
document_store_str 1
active_str 0
description ObjectiveLittle is known about the role of physical activity accumulation in cardiovascular disease risk for children with type 1 diabetes. Improved insight to identify factors of influence in key health outcomes could be provided by considering the entire physical activity profile.MethodsPulse wave velocity (PWV), augmentation index and heart rate variability (HRV) were assessed cross‐sectionally in children with (n = 29, 12.1 ± 2.1 years) and without (n = 19, 12.1 ± 2.1 years) type 1 diabetes. Time spent sedentary and in each physical activity intensity, intensity gradient and average acceleration were derived from seven consecutive days of monitoring with wrist‐worn accelerometry. Comparison between groups and influence of physical activity accumulation on cardiovascular metrics were explored with linear mixed models.ResultsDiabetic children demonstrated a higher PWV and a greater volume of light physical activity (p < 0.01), a more negative intensity gradient (p < 0.01), a lower average acceleration and less time in bouted moderate‐to‐vigorous physical activity (MVPA; p < 0.05). Overall, intensity gradient was strongly correlated with average acceleration, MVPA and bouted MVPA (r2 = 0.89, r2 = 0.80, r2 = 0.79, respectively; all p < 0.05), while average acceleration was correlated with MVPA and bouted MVPA (r2 = 0.85, r2 = 0.83, respectively; p < 0.05). Accounting for disease status, intensity gradient and average acceleration were significant predictors of HRV indices (p < 0.05) and PWV (p < 0.01, p < 0.05, respectively).ConclusionOverall, MVPA was most associated with central stiffness, highlighting the importance of meeting activity guidelines. Diabetic children demonstrated poorer cardiovascular health than their counterparts, likely attributable to a lower intensity and physical activity volume, identifying physical activity intensity as a key target for future interventions.
published_date 2021-03-01T04:24:25Z
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