No Cover Image

Journal article 28 views 3 downloads

Improved Nocturnal Glycaemia and Reduced Insulin Use Following Clinical Exercise Trial Participation in Individuals With Type 1 Diabetes / Olivia McCarthy; Rachel Deere; Max L. Eckstein; Jason Pitt; Benjamin Wellman; Steve Bain; Othmar Moser; Richard Bracken

Frontiers in Public Health, Volume: 8

Swansea University Authors: Olivia, McCarthy, Rachel, Deere, Jason, Pitt, Benjamin, Wellman, Steve, Bain, Richard, Bracken

  • 55783.pdf

    PDF | Version of Record

    © 2021 McCarthy, Deere, Eckstein, Pitt, Wellman, Bain, Moser and Bracken. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)

    Download (535.76KB)

Abstract

Aim: To explore the influence of clinical exercise trial participation on glycaemia and insulin therapy use in adults with type 1 diabetes (T1D). Research Design and Methods: This study involved a secondary analysis of data collected from 16 individuals with T1D who completed a randomized clinical t...

Full description

Published in: Frontiers in Public Health
ISSN: 2296-2565
Published: Frontiers Media SA 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa55783
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Aim: To explore the influence of clinical exercise trial participation on glycaemia and insulin therapy use in adults with type 1 diabetes (T1D). Research Design and Methods: This study involved a secondary analysis of data collected from 16 individuals with T1D who completed a randomized clinical trial consisting of 23-h in-patient phases with a 45-min evening bout of moderate intensity continuous exercise. Participants were switched from their usual basal-bolus therapy to ultra-long acting insulin degludec and rapid-acting insulin aspart as well as provided with unblinded interstitial flash-glucose monitoring systems. To assess the impact of clinical trial participation, weekly data obtained at the screening visit (pre-study involvement) were compared against those collated on the last experimental visit (post-study involvement). Interstitial glucose [iG] data were split into distinct glycaemic ranges and stratified into day (06:00–23:59) and night (00:00–05:59) time periods. A p-value of ≤ 0.05 was accepted for significance. Results: Following study completion, there were significant decreases in both the mean nocturnal iG concentration (Δ-0.9 ± 4.5 mmol.L−1, p < 0.001) and the time spent in severe hyperglycaemia (Δ-7.2 ± 9.8%, p = 0.028) during the night-time period. The total daily (Δ-7.3 ± 8.4 IU, p = 0.003) and basal only (Δ-2.3 ± 3.8 IU, p = 0.033) insulin dose requirements were reduced over the course of study involvement. Conclusions: Participation in clinical research may foster improved nocturnal glycaemia and reduced insulin therapy use in people with T1D. Recognition of these outcomes may help encourage volunteers to partake in clinical research opportunities for improved diabetes-related health outcomes. Clinical Trial Registration: DRKS.de; DRKS00013509.
Keywords: type 1 diabetes (T1D), exercise, insulin, glycaemia, research participant experience
College: College of Engineering