Journal article 778 views 103 downloads
3D Bioprinting and the Future of Surgery
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Iain Whitaker
Frontiers in Surgery, Volume: 7
Swansea University Authors:
Thomas Jovic, Emman Thomson, Zita Jessop , Iain Whitaker
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© 2020 Jovic, Combellack, Jessop and Whitaker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
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DOI (Published version): 10.3389/fsurg.2020.609836
Abstract
Introduction: The disciplines of 3D bioprinting and surgery have witnessed incremental transformations over the last century. 3D bioprinting is a convergence of biology and engineering technologies, mirroring the clinical need to produce viable biological tissue through advancements in printing, reg...
| Published in: | Frontiers in Surgery |
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| ISSN: | 2296-875X |
| Published: |
Frontiers Media SA
2020
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa55848 |
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| Abstract: |
Introduction: The disciplines of 3D bioprinting and surgery have witnessed incremental transformations over the last century. 3D bioprinting is a convergence of biology and engineering technologies, mirroring the clinical need to produce viable biological tissue through advancements in printing, regenerative medicine and materials science. To outline the current and future challenges of 3D bioprinting technology in surgery. Methods: A comprehensive literature search was undertaken using the MEDLINE, EMBASE and Google Scholar databases between 2000 and 2019. A narrative synthesis of the resulting literature was produced to discuss 3D bioprinting, current and future challenges, the role in personalized medicine and transplantation surgery and the global 3D bioprinting market. Results: The next 20 years will see the advent of bioprinted implants for surgical use, however the path to clinical incorporation will be fraught with an array of ethical, regulatory and technical challenges of which each must be surmounted. Previous clinical cases where regulatory processes have been bypassed have led to poor outcomes and controversy. Speculated roles of 3D bioprinting in surgery include the production of de novo organs for transplantation and use of autologous cellular material for personalized medicine. The promise of these technologies has sparked an industrial revolution, leading to an exponential growth of the 3D bioprinting market worth billions of dollars. Conclusion: Effective translation requires the input of scientists, engineers, clinicians, and regulatory bodies: there is a need for a collaborative effort to translate this impactful technology into a real-world healthcare setting and potentially transform the future of surgery. |
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| Keywords: |
3D printing, transplantation, biotechnology, bioprinting, reconstruction |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
UKRI, MR/N002431/1 |