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Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension / Latif Miah, Huw Strafford, Beata Fonferko-Shadrach, Joseph Hollinghurst, Inder M.S. Sawhney, Savvas Hadjikoutis, Mark Rees, Robert Powell, Arron S. Lacey, Owen Pickrell
Neurology, Volume: 96, Issue: 8, Pages: e1251 - e1261
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Objective: To characterise trends in incidence, prevalence, and healthcare outcomes in the idiopathic intracranial hypertension (IIH) population in Wales using routinely collected healthcare data.Methods: We used and validated primary and secondary care IIH diagnosis codes within the Secure Anonymis...
Ovid Technologies (Wolters Kluwer Health)
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Objective: To characterise trends in incidence, prevalence, and healthcare outcomes in the idiopathic intracranial hypertension (IIH) population in Wales using routinely collected healthcare data.Methods: We used and validated primary and secondary care IIH diagnosis codes within the Secure Anonymised Information Linkage databank, to ascertain IIH cases and controls, in a retrospective cohort study between 2003 and 2017. We recorded body mass index (BMI), deprivation quintile, CSF diversion surgery and unscheduled hospital admissions in case and control cohorts.Results: We analysed 35 million patient years of data. There were 1765 cases of IIH in 2017 (85% female). The prevalence and incidence of IIH in 2017 was 76/100,000 and 7.8/100,000/year, a significant increase from 2003 (corresponding figures=12/100,000 and 2.3/100,000/year) (p<0.001). IIH prevalence is associated with increasing BMI and increasing deprivation. The odds ratio for developing IIH in the least deprived quintile compared to the most deprived quintile, adjusted for gender and BMI, was 0.65 (95% CI 0.55 to 0.76). 9% of IIH cases had CSF shunts with less than 0.2% having bariatric surgery. Unscheduled hospital admissions were higher in the IIH cohort compared to controls (rate ratio=5.28, p<0.001) and in individuals with IIH and CSF shunts compared to those without shunts (rate ratio=2.02, p<0.01).Conclusions: IIH incidence and prevalence is increasing considerably, corresponding to population increases in BMI, and is associated with increased deprivation. This has important implications for healthcare professionals and policy makers given the comorbidities, complications and increased healthcare utilization associated with IIH
Idiopathic intracranial hypertension, Cohort studies, Prevalence studies, Incidence studies, Quality of life
Swansea University Medical School