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Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing

Rahul Kapoore Orcid Logo, Gloria Padmaperuma, Supattra Maneein, Seetharaman Vaidyanathan

Critical Reviews in Biotechnology, Volume: 42 (2022), Issue: 1, Pages: 1 - 27

Swansea University Author: Rahul Kapoore Orcid Logo

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DOI (Published version): 10.1080/07388551.2021.1921691

Abstract

The application of microbial co-cultures is now recognized in the fields of biotechnology, ecology, and medicine. Understanding the biological interactions that govern the association of microorganisms would shape the way in which artificial/synthetic co-cultures or consortia are developed. The abil...

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Published in: Critical Reviews in Biotechnology
ISSN: 0738-8551 1549-7801
Published: Informa UK Limited 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa56889
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first_indexed 2021-05-18T09:10:29Z
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spelling 2022-02-14T13:39:37.2526170 v2 56889 2021-05-18 Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing 5583be4600daecd670edac16f6e77e88 0000-0002-2287-0619 Rahul Kapoore Rahul Kapoore true false 2021-05-18 SBI The application of microbial co-cultures is now recognized in the fields of biotechnology, ecology, and medicine. Understanding the biological interactions that govern the association of microorganisms would shape the way in which artificial/synthetic co-cultures or consortia are developed. The ability to accurately predict and control cell-to-cell interactions fully would be a significant enabler in synthetic biology. Co-culturing method development holds the key to strategically engineer environments in which the co-cultured microorganism can be monitored. Various approaches have been employed which aim to emulate the natural environment and gain access to the untapped natural resources emerging from cross-talk between partners. Amongst these methods are the use of a communal liquid medium for growth, use of a solid–liquid interface, membrane separation, spatial separation, and use of microfluidics systems. Maximizing the information content of interactions monitored is one of the major challenges that needs to be addressed by these designs. This review critically evaluates the significance and drawbacks of the co-culturing approaches used to this day in biotechnological applications, relevant to biomanufacturing. It is recommended that experimental results for a co-cultured species should be validated with different co-culture approaches due to variations in interactions that could exist as a result of the culturing method selected. Journal Article Critical Reviews in Biotechnology 42 (2022) 1 1 27 Informa UK Limited 0738-8551 1549-7801 Co-culturing techniques; microbial consortia; infochemicals; metabolites; metabolomics; encapsulation; membrane separation; spatial separation; microfluidics; biofilms 12 5 2021 2021-05-12 10.1080/07388551.2021.1921691 COLLEGE NANME Biosciences COLLEGE CODE SBI Swansea University 2022-02-14T13:39:37.2526170 2021-05-18T10:07:44.4385737 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Rahul Kapoore 0000-0002-2287-0619 1 Gloria Padmaperuma 2 Supattra Maneein 3 Seetharaman Vaidyanathan 4 56889__19921__6e74500eda924df48ae385591e732566.pdf 56889.pdf 2021-05-18T10:32:33.6083627 Output 4196583 application/pdf Version of Record true ©2021 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing
spellingShingle Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing
Rahul Kapoore
title_short Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing
title_full Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing
title_fullStr Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing
title_full_unstemmed Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing
title_sort Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing
author_id_str_mv 5583be4600daecd670edac16f6e77e88
author_id_fullname_str_mv 5583be4600daecd670edac16f6e77e88_***_Rahul Kapoore
author Rahul Kapoore
author2 Rahul Kapoore
Gloria Padmaperuma
Supattra Maneein
Seetharaman Vaidyanathan
format Journal article
container_title Critical Reviews in Biotechnology
container_volume 42 (2022)
container_issue 1
container_start_page 1
publishDate 2021
institution Swansea University
issn 0738-8551
1549-7801
doi_str_mv 10.1080/07388551.2021.1921691
publisher Informa UK Limited
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description The application of microbial co-cultures is now recognized in the fields of biotechnology, ecology, and medicine. Understanding the biological interactions that govern the association of microorganisms would shape the way in which artificial/synthetic co-cultures or consortia are developed. The ability to accurately predict and control cell-to-cell interactions fully would be a significant enabler in synthetic biology. Co-culturing method development holds the key to strategically engineer environments in which the co-cultured microorganism can be monitored. Various approaches have been employed which aim to emulate the natural environment and gain access to the untapped natural resources emerging from cross-talk between partners. Amongst these methods are the use of a communal liquid medium for growth, use of a solid–liquid interface, membrane separation, spatial separation, and use of microfluidics systems. Maximizing the information content of interactions monitored is one of the major challenges that needs to be addressed by these designs. This review critically evaluates the significance and drawbacks of the co-culturing approaches used to this day in biotechnological applications, relevant to biomanufacturing. It is recommended that experimental results for a co-cultured species should be validated with different co-culture approaches due to variations in interactions that could exist as a result of the culturing method selected.
published_date 2021-05-12T04:12:11Z
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