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Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis

Lauren L. O’Mahoney, Rachel Churm Orcid Logo, Antonios Stavropoulos-Kalinoglou, Ramzi A. Ajjan, Nicolas M. Orsi, Georgia Mappa, Oliver J. Price, Matthew D. Campbell

Canadian Journal of Diabetes, Volume: 46, Issue: 2

Swansea University Author: Rachel Churm Orcid Logo

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DOI (Published version): 10.1016/j.jcjd.2021.06.005

Abstract

PurposeThe aim of this study was to assess the relationship between specific erythrocyte fatty acids levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).MethodsWe analysed baseline pretreatment data in a subset of 23 patients with T1D from a previously publis...

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Published in: Canadian Journal of Diabetes
ISSN: 1499-2671
Published: Elsevier BV 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa57251
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Estimated glucose disposal rate was used to identify and categorise patients with IR. We utilised principal component analysis (PCA) to cluster vascular biomarkers to compute a single &#x2018;vascular signal&#x2019; and employed univariate linear regression models to investigate the association with IR and fatty acid profiles.ResultsSubjects with IR displayed significantly higher levels of linoleic acid (p=0.001), lower levels of eicosapentaenoic acid (EPA) (p&lt;0.001), lower total omega-3 polyunsaturated fatty acid (n-3PUFA) (p&lt;0.006), and an increased n-6PUFA:n-3PUFA ratio (p=0.001). IR was associated with significantly higher linoleic acid levels, total n-6PUFA, and an increased ratio of n-6PUFA:n-3PUFA, and negatively associated with arachidonic and eicosapentaenoic acid levels, total saturated fatty acid, and total n-3PUFA. The PCA-derived vascular biomarker cluster was positively associated with linoleic acid, n-6PUFA:n-3PUFA ratio and inversely associated with EPA.ConclusionSpecific erythrocyte membrane fatty acid compositions are associated with impaired vascular health and IR in adults with T1D. These findings suggest that IR and risk of associated complications may be influenced by specific fatty acid profiles, and thus potentially modified by the selective targeting of dietary fatty acids.</abstract><type>Journal Article</type><journal>Canadian Journal of Diabetes</journal><volume>46</volume><journalNumber>2</journalNumber><paginationStart/><paginationEnd/><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1499-2671</issnPrint><issnElectronic/><keywords>Type 1 diabetes, vascular health, insulin resistance, erythrocyte fatty acids</keywords><publishedDay>26</publishedDay><publishedMonth>6</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-06-26</publishedDate><doi>10.1016/j.jcjd.2021.06.005</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2022-04-19T16:04:45.4806912</lastEdited><Created>2021-07-01T09:34:34.1395668</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences</level></path><authors><author><firstname>Lauren L.</firstname><surname>O&#x2019;Mahoney</surname><order>1</order></author><author><firstname>Rachel</firstname><surname>Churm</surname><orcid>0000-0001-9855-6282</orcid><order>2</order></author><author><firstname>Antonios</firstname><surname>Stavropoulos-Kalinoglou</surname><order>3</order></author><author><firstname>Ramzi A.</firstname><surname>Ajjan</surname><order>4</order></author><author><firstname>Nicolas M.</firstname><surname>Orsi</surname><order>5</order></author><author><firstname>Georgia</firstname><surname>Mappa</surname><order>6</order></author><author><firstname>Oliver J.</firstname><surname>Price</surname><order>7</order></author><author><firstname>Matthew D.</firstname><surname>Campbell</surname><order>8</order></author></authors><documents><document><filename>57251__20312__228eb8e1838f402fa1c6e0111fb2f569.pdf</filename><originalFilename>57251.pdf</originalFilename><uploaded>2021-07-01T09:36:12.3609604</uploaded><type>Output</type><contentLength>1480188</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2022-06-26T00:00:00.0000000</embargoDate><documentNotes>Released under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>fre</language><licence>http://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2022-04-19T16:04:45.4806912 v2 57251 2021-07-01 Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis c6cd8267ff0b13f2ea333bbfefdae144 0000-0001-9855-6282 Rachel Churm Rachel Churm true false 2021-07-01 STSC PurposeThe aim of this study was to assess the relationship between specific erythrocyte fatty acids levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).MethodsWe analysed baseline pretreatment data in a subset of 23 patients with T1D from a previously published randomised controlled trial consisting of comprehensive erythrocyte-derived fatty acid profiles and a panel of inflammation-associated endothelial markers. Estimated glucose disposal rate was used to identify and categorise patients with IR. We utilised principal component analysis (PCA) to cluster vascular biomarkers to compute a single ‘vascular signal’ and employed univariate linear regression models to investigate the association with IR and fatty acid profiles.ResultsSubjects with IR displayed significantly higher levels of linoleic acid (p=0.001), lower levels of eicosapentaenoic acid (EPA) (p<0.001), lower total omega-3 polyunsaturated fatty acid (n-3PUFA) (p<0.006), and an increased n-6PUFA:n-3PUFA ratio (p=0.001). IR was associated with significantly higher linoleic acid levels, total n-6PUFA, and an increased ratio of n-6PUFA:n-3PUFA, and negatively associated with arachidonic and eicosapentaenoic acid levels, total saturated fatty acid, and total n-3PUFA. The PCA-derived vascular biomarker cluster was positively associated with linoleic acid, n-6PUFA:n-3PUFA ratio and inversely associated with EPA.ConclusionSpecific erythrocyte membrane fatty acid compositions are associated with impaired vascular health and IR in adults with T1D. These findings suggest that IR and risk of associated complications may be influenced by specific fatty acid profiles, and thus potentially modified by the selective targeting of dietary fatty acids. Journal Article Canadian Journal of Diabetes 46 2 Elsevier BV 1499-2671 Type 1 diabetes, vascular health, insulin resistance, erythrocyte fatty acids 26 6 2021 2021-06-26 10.1016/j.jcjd.2021.06.005 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2022-04-19T16:04:45.4806912 2021-07-01T09:34:34.1395668 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Lauren L. O’Mahoney 1 Rachel Churm 0000-0001-9855-6282 2 Antonios Stavropoulos-Kalinoglou 3 Ramzi A. Ajjan 4 Nicolas M. Orsi 5 Georgia Mappa 6 Oliver J. Price 7 Matthew D. Campbell 8 57251__20312__228eb8e1838f402fa1c6e0111fb2f569.pdf 57251.pdf 2021-07-01T09:36:12.3609604 Output 1480188 application/pdf Accepted Manuscript true 2022-06-26T00:00:00.0000000 Released under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License true fre http://creativecommons.org/licenses/by-nc-nd/4.0/
title Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis
spellingShingle Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis
Rachel Churm
title_short Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis
title_full Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis
title_fullStr Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis
title_full_unstemmed Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis
title_sort Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis
author_id_str_mv c6cd8267ff0b13f2ea333bbfefdae144
author_id_fullname_str_mv c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel Churm
author Rachel Churm
author2 Lauren L. O’Mahoney
Rachel Churm
Antonios Stavropoulos-Kalinoglou
Ramzi A. Ajjan
Nicolas M. Orsi
Georgia Mappa
Oliver J. Price
Matthew D. Campbell
format Journal article
container_title Canadian Journal of Diabetes
container_volume 46
container_issue 2
publishDate 2021
institution Swansea University
issn 1499-2671
doi_str_mv 10.1016/j.jcjd.2021.06.005
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
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description PurposeThe aim of this study was to assess the relationship between specific erythrocyte fatty acids levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).MethodsWe analysed baseline pretreatment data in a subset of 23 patients with T1D from a previously published randomised controlled trial consisting of comprehensive erythrocyte-derived fatty acid profiles and a panel of inflammation-associated endothelial markers. Estimated glucose disposal rate was used to identify and categorise patients with IR. We utilised principal component analysis (PCA) to cluster vascular biomarkers to compute a single ‘vascular signal’ and employed univariate linear regression models to investigate the association with IR and fatty acid profiles.ResultsSubjects with IR displayed significantly higher levels of linoleic acid (p=0.001), lower levels of eicosapentaenoic acid (EPA) (p<0.001), lower total omega-3 polyunsaturated fatty acid (n-3PUFA) (p<0.006), and an increased n-6PUFA:n-3PUFA ratio (p=0.001). IR was associated with significantly higher linoleic acid levels, total n-6PUFA, and an increased ratio of n-6PUFA:n-3PUFA, and negatively associated with arachidonic and eicosapentaenoic acid levels, total saturated fatty acid, and total n-3PUFA. The PCA-derived vascular biomarker cluster was positively associated with linoleic acid, n-6PUFA:n-3PUFA ratio and inversely associated with EPA.ConclusionSpecific erythrocyte membrane fatty acid compositions are associated with impaired vascular health and IR in adults with T1D. These findings suggest that IR and risk of associated complications may be influenced by specific fatty acid profiles, and thus potentially modified by the selective targeting of dietary fatty acids.
published_date 2021-06-26T04:12:50Z
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