Controlled viscoelastic particle encapsulation in microfluidic devices

Shahrivar, Keshvad; Giudice, Francesco Del

doi:10.1039/d1sm00941a

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Controlled viscoelastic particle encapsulation in microfluidic devices

Keshvad Shahrivar, Francesco Del Giudice

Soft Matter, Volume: 17, Issue: 35, Pages: 8068 - 8077

Swansea University Authors: Keshvad Shahrivar, Francesco Del Giudice

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DOI (Published version): 10.1039/d1sm00941a

Abstract

The encapsulation of particles in droplets using microfluidic devices finds application across severalfields ranging from biomedical engineering to materials science. The encapsulation process, however, isoften affected by poor single encapsulation efficiency, quantified by the Poisson statistics, w...

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Published in:	Soft Matter
ISSN:	1744-683X 1744-6848
Published:	Royal Society of Chemistry (RSC) 2021
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URI:	https://cronfa.swan.ac.uk/Record/cronfa57561
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spelling	2022-08-12T16:17:41.9949056 v2 57561 2021-08-09 Controlled viscoelastic particle encapsulation in microfluidic devices b012e0b09453eca7c7ae1cce164ccff9 Keshvad Shahrivar Keshvad Shahrivar true false 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2021-08-09 CHEG The encapsulation of particles in droplets using microfluidic devices finds application across severalfields ranging from biomedical engineering to materials science. The encapsulation process, however, isoften affected by poor single encapsulation efficiency, quantified by the Poisson statistics, with dropletscontaining more than one particle or with several empty droplets. We here demonstrate that viscoelasticaqueous solutions of xanthan gum enable controlled single particle encapsulation in microfluidic deviceswith a single encapsulation efficiency up to 2-fold larger than the one predicted by the Poissonstatistics. We achieved such a result by identifying viscoelastic xanthan gum aqueous solutions thatcould drive particle ordering before approaching the encapsulation area and simultaneously formuniform droplets. This is the first experimental evidence of viscoelastic encapsulation in microfluidicdevices, the existing literature on the subject being focused on Newtonian suspending liquids. We firststudied the process of viscoelastic droplet formation, and found that the droplet length normalised bythe channel diameter scaled as predicted for Newtonian solutions. At variance with Newtonian solutions,we observed that the droplet formation mechanism became unstable above critical values of theWeissenberg number, which quantifies the elasticity of the xanthan gum solutions carrying the particles.In terms of controlled encapsulation, we discovered that the single encapsulation efficiency was largerthan the Poisson values in a specific range of xanthan gum mass concentrations. Finally, we introducedan empirical formula that can help the design of controlled viscoelastic encapsulation systems. Journal Article Soft Matter 17 35 8068 8077 Royal Society of Chemistry (RSC) 1744-683X 1744-6848 9 8 2021 2021-08-09 10.1039/d1sm00941a COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University External research funder(s) paid the OA fee (includes OA grants disbursed by the Library) UKRI, EP/S036490/1 2022-08-12T16:17:41.9949056 2021-08-09T18:34:57.1690552 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Keshvad Shahrivar 1 Francesco Del Giudice 0000-0002-9414-6937 2 57561__20723__a3785a2ac26745878c087788e6f17afa.pdf 57561.VOR.pdf 2021-08-31T11:48:57.1523440 Output 3865035 application/pdf Version of Record true Copyright: The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. true eng http://creativecommons.org/licenses/by/4.0/
title	Controlled viscoelastic particle encapsulation in microfluidic devices
spellingShingle	Controlled viscoelastic particle encapsulation in microfluidic devices Keshvad Shahrivar Francesco Del Giudice
title_short	Controlled viscoelastic particle encapsulation in microfluidic devices
title_full	Controlled viscoelastic particle encapsulation in microfluidic devices
title_fullStr	Controlled viscoelastic particle encapsulation in microfluidic devices
title_full_unstemmed	Controlled viscoelastic particle encapsulation in microfluidic devices
title_sort	Controlled viscoelastic particle encapsulation in microfluidic devices
author_id_str_mv	b012e0b09453eca7c7ae1cce164ccff9 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv	b012e0b09453eca7c7ae1cce164ccff9_*_Keshvad Shahrivar 742d483071479b44d7888e16166b1309_*_Francesco Del Giudice
author	Keshvad Shahrivar Francesco Del Giudice
author2	Keshvad Shahrivar Francesco Del Giudice
format	Journal article
container_title	Soft Matter
container_volume	17
container_issue	35
container_start_page	8068
publishDate	2021
institution	Swansea University
issn	1744-683X 1744-6848
doi_str_mv	10.1039/d1sm00941a
publisher	Royal Society of Chemistry (RSC)
college_str	Faculty of Science and Engineering
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hierarchy_top_title	Faculty of Science and Engineering
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department_str	School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
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description	The encapsulation of particles in droplets using microfluidic devices finds application across severalfields ranging from biomedical engineering to materials science. The encapsulation process, however, isoften affected by poor single encapsulation efficiency, quantified by the Poisson statistics, with dropletscontaining more than one particle or with several empty droplets. We here demonstrate that viscoelasticaqueous solutions of xanthan gum enable controlled single particle encapsulation in microfluidic deviceswith a single encapsulation efficiency up to 2-fold larger than the one predicted by the Poissonstatistics. We achieved such a result by identifying viscoelastic xanthan gum aqueous solutions thatcould drive particle ordering before approaching the encapsulation area and simultaneously formuniform droplets. This is the first experimental evidence of viscoelastic encapsulation in microfluidicdevices, the existing literature on the subject being focused on Newtonian suspending liquids. We firststudied the process of viscoelastic droplet formation, and found that the droplet length normalised bythe channel diameter scaled as predicted for Newtonian solutions. At variance with Newtonian solutions,we observed that the droplet formation mechanism became unstable above critical values of theWeissenberg number, which quantifies the elasticity of the xanthan gum solutions carrying the particles.In terms of controlled encapsulation, we discovered that the single encapsulation efficiency was largerthan the Poisson values in a specific range of xanthan gum mass concentrations. Finally, we introducedan empirical formula that can help the design of controlled viscoelastic encapsulation systems.
published_date	2021-08-09T04:13:24Z
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Controlled viscoelastic particle encapsulation in microfluidic devices

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