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Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19

Patrick Holford, Anitra C. Carr, Thomas Jovic, Stephen Ali, Iain Whitaker, Paul E. Marik, A. David Smith

Nutrients, Volume: 12, Issue: 12, Start page: 3760

Swansea University Authors: Thomas Jovic, Stephen Ali, Iain Whitaker

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DOI (Published version): 10.3390/nu12123760

Abstract

There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This lite...

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Published in: Nutrients
ISSN: 2072-6643
Published: MDPI AG 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa57714
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spelling 2021-09-17T17:03:07.5665224 v2 57714 2021-08-30 Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19 7d95ed2bceb18fc0fdfd4048277c6eed Thomas Jovic Thomas Jovic true false 8c210736c07c6aa2514e0f6b3cfd9764 Stephen Ali Stephen Ali true false 830074c59291938a55b480dcbee4697e Iain Whitaker Iain Whitaker true false 2021-08-30 BMS There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6–24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients’ vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19. Journal Article Nutrients 12 12 3760 MDPI AG 2072-6643 COVID-19; SARS-CoV-2; coronavirus; vitamin C; ascorbate; colds; pneumonia; sepsis; immunonutrition; supplementation 7 12 2020 2020-12-07 10.3390/nu12123760 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Other This research received no external funding [Article] Action Medical Research [Research Fish] 2782 2021-09-17T17:03:07.5665224 2021-08-30T15:39:18.3852842 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Patrick Holford 1 Anitra C. Carr 2 Thomas Jovic 3 Stephen Ali 4 Iain Whitaker 5 Paul E. Marik 6 A. David Smith 7 57714__20721__953cecd324194a3abefd050b3563da8f.pdf VOR.nutrients-12-03760-v4.pdf 2021-08-30T15:42:53.8967763 Output 5589381 application/pdf Version of Record true This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC-BY) Licence. true eng This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution
title Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
spellingShingle Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Thomas Jovic
Stephen Ali
Iain Whitaker
title_short Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
title_full Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
title_fullStr Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
title_full_unstemmed Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
title_sort Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
author_id_str_mv 7d95ed2bceb18fc0fdfd4048277c6eed
8c210736c07c6aa2514e0f6b3cfd9764
830074c59291938a55b480dcbee4697e
author_id_fullname_str_mv 7d95ed2bceb18fc0fdfd4048277c6eed_***_Thomas Jovic
8c210736c07c6aa2514e0f6b3cfd9764_***_Stephen Ali
830074c59291938a55b480dcbee4697e_***_Iain Whitaker
author Thomas Jovic
Stephen Ali
Iain Whitaker
author2 Patrick Holford
Anitra C. Carr
Thomas Jovic
Stephen Ali
Iain Whitaker
Paul E. Marik
A. David Smith
format Journal article
container_title Nutrients
container_volume 12
container_issue 12
container_start_page 3760
publishDate 2020
institution Swansea University
issn 2072-6643
doi_str_mv 10.3390/nu12123760
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6–24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients’ vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19.
published_date 2020-12-07T04:13:39Z
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