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Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients

Erifyli Piastopoulou, Parvaiz Ali, Gianfilippo Bertelli, Martyn Heatley, Maung Moe, Chandramohan Murugesan, Gareth Stratton Orcid Logo, Michael Lewis

Physiological Measurement, Volume: 42, Issue: 10

Swansea University Authors: Erifyli Piastopoulou, Parvaiz Ali, Chandramohan Murugesan, Gareth Stratton Orcid Logo, Michael Lewis

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DOI (Published version): 10.1088/1361-6579/ac28e5

Abstract

Objective: Breast cancer treatment can negatively impact cardiac function in some breast cancer patients. Current methods (MUGA, echocardiography) used in clinical practice to detect abnormal cardiac changes as a result of treatment suffer from important limitations. Use of alternative techniques th...

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Published in: Physiological Measurement
ISSN: 0967-3334 1361-6579
Published: IOP Publishing
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Current methods (MUGA, echocardiography) used in clinical practice to detect abnormal cardiac changes as a result of treatment suffer from important limitations. Use of alternative techniques that would offer safe, inexpensive and non-invasive cardiac function assessment in this population would be highly advantageous. The aim of this study was to examine the agreement between impedance cardiography (ICG) and cardiac magnetic resonance imaging (CMR) in quantifying stroke volume (SV), cardiac output (CO) and end-diastolic volume (EDV) in this population. Approach: Sixteen breast cancer patients underwent ICG and CMR assessments at three time-points (before treatment, immediately after chemotherapy, and four months after chemotherapy). Bland-Altman analysis was used to quantify the accuracy and precision of ICG (relative to CMR) in estimating absolute values of SV, CO and EDV. Four methods (concordance rate, polar concordance rate, clinical concordance rate and trend interchangeability rate) were also used to assess ICG performance in tracking changes in these variables. Main results: Bland-Altman analysis showed that the accuracy of ICG relative to CMR was -3.1 ml (SV), 0.2 L&#xB7;min-1 (CO) and -26.0 ml (EDV) and precision was 13.2 ml (SV), 1.1 L&#xB7;min-1 (CO) and 20.1 ml (EDV), respectively. Trending ability assessment showed that 1) the concordance rate was 87% (SV), 73% (CO) and 73% (EDV), 2) the polar concordance rate was 67% (SV), 53% (CO) and 33% (EDV), 3) the clinical concordance rate was 33% (SV), 40% (CO) and 20% (EDV) and 4) the trend interchangeability rate was 29% (SV), 43% (CO) and 17% (EDV), respectively. Significance: Our findings show that, although ICG showed good accuracy for absolute SV and CO measurements and for CO and EDV changes, precision was poor for all variables in terms of both absolute measurements and trend tracking performance. This suggests that ICG cannot be used interchangeably with CMR in breast cancer patients.</abstract><type>Journal Article</type><journal>Physiological Measurement</journal><volume>42</volume><journalNumber>10</journalNumber><paginationStart/><paginationEnd/><publisher>IOP Publishing</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0967-3334</issnPrint><issnElectronic>1361-6579</issnElectronic><keywords>cardiotoxicity, impedance cardiography, cardiac magnetic resonance imaging, Bland-Altman analysis, trending ability, method-comparison study, breast cancer</keywords><publishedDay>0</publishedDay><publishedMonth>0</publishedMonth><publishedYear>0</publishedYear><publishedDate>0001-01-01</publishedDate><doi>10.1088/1361-6579/ac28e5</doi><url/><notes/><college>COLLEGE NANME</college><department>Science and Engineering - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGSEN</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2021-11-22T13:51:26.5931216</lastEdited><Created>2021-09-28T09:40:38.4153571</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Uncategorised</level></path><authors><author><firstname>Erifyli</firstname><surname>Piastopoulou</surname><order>1</order></author><author><firstname>Parvaiz</firstname><surname>Ali</surname><order>2</order></author><author><firstname>Gianfilippo</firstname><surname>Bertelli</surname><order>3</order></author><author><firstname>Martyn</firstname><surname>Heatley</surname><order>4</order></author><author><firstname>Maung</firstname><surname>Moe</surname><order>5</order></author><author><firstname>Chandramohan</firstname><surname>Murugesan</surname><order>6</order></author><author><firstname>Gareth</firstname><surname>Stratton</surname><orcid>0000-0001-5618-0803</orcid><order>7</order></author><author><firstname>Michael</firstname><surname>Lewis</surname><order>8</order></author></authors><documents><document><filename>58119__21024__d424f0d19e5c47b986c7790bc51565f2.pdf</filename><originalFilename>58119.pdf</originalFilename><uploaded>2021-09-28T09:42:22.7288789</uploaded><type>Output</type><contentLength>1268468</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2022-09-21T00:00:00.0000000</embargoDate><documentNotes>Released under the terms of a CC BY-NC-ND 3.0 licence</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by-nc-nd/3.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2021-11-22T13:51:26.5931216 v2 58119 2021-09-28 Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients 1bcaddedf0a3484b64cc4df6ee9b07d5 Erifyli Piastopoulou Erifyli Piastopoulou true false d03adb0b0294cba80e020e423903caa6 Parvaiz Ali Parvaiz Ali true false e003fb59a193203e6949459dd27cf0bb Chandramohan Murugesan Chandramohan Murugesan true false 6d62b2ed126961bed81a94a2beba8a01 0000-0001-5618-0803 Gareth Stratton Gareth Stratton true false b59c8f5c056bac7e6995385f22ad1639 Michael Lewis Michael Lewis true false 2021-09-28 FGSEN Objective: Breast cancer treatment can negatively impact cardiac function in some breast cancer patients. Current methods (MUGA, echocardiography) used in clinical practice to detect abnormal cardiac changes as a result of treatment suffer from important limitations. Use of alternative techniques that would offer safe, inexpensive and non-invasive cardiac function assessment in this population would be highly advantageous. The aim of this study was to examine the agreement between impedance cardiography (ICG) and cardiac magnetic resonance imaging (CMR) in quantifying stroke volume (SV), cardiac output (CO) and end-diastolic volume (EDV) in this population. Approach: Sixteen breast cancer patients underwent ICG and CMR assessments at three time-points (before treatment, immediately after chemotherapy, and four months after chemotherapy). Bland-Altman analysis was used to quantify the accuracy and precision of ICG (relative to CMR) in estimating absolute values of SV, CO and EDV. Four methods (concordance rate, polar concordance rate, clinical concordance rate and trend interchangeability rate) were also used to assess ICG performance in tracking changes in these variables. Main results: Bland-Altman analysis showed that the accuracy of ICG relative to CMR was -3.1 ml (SV), 0.2 L·min-1 (CO) and -26.0 ml (EDV) and precision was 13.2 ml (SV), 1.1 L·min-1 (CO) and 20.1 ml (EDV), respectively. Trending ability assessment showed that 1) the concordance rate was 87% (SV), 73% (CO) and 73% (EDV), 2) the polar concordance rate was 67% (SV), 53% (CO) and 33% (EDV), 3) the clinical concordance rate was 33% (SV), 40% (CO) and 20% (EDV) and 4) the trend interchangeability rate was 29% (SV), 43% (CO) and 17% (EDV), respectively. Significance: Our findings show that, although ICG showed good accuracy for absolute SV and CO measurements and for CO and EDV changes, precision was poor for all variables in terms of both absolute measurements and trend tracking performance. This suggests that ICG cannot be used interchangeably with CMR in breast cancer patients. Journal Article Physiological Measurement 42 10 IOP Publishing 0967-3334 1361-6579 cardiotoxicity, impedance cardiography, cardiac magnetic resonance imaging, Bland-Altman analysis, trending ability, method-comparison study, breast cancer 0 0 0 0001-01-01 10.1088/1361-6579/ac28e5 COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University 2021-11-22T13:51:26.5931216 2021-09-28T09:40:38.4153571 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Erifyli Piastopoulou 1 Parvaiz Ali 2 Gianfilippo Bertelli 3 Martyn Heatley 4 Maung Moe 5 Chandramohan Murugesan 6 Gareth Stratton 0000-0001-5618-0803 7 Michael Lewis 8 58119__21024__d424f0d19e5c47b986c7790bc51565f2.pdf 58119.pdf 2021-09-28T09:42:22.7288789 Output 1268468 application/pdf Accepted Manuscript true 2022-09-21T00:00:00.0000000 Released under the terms of a CC BY-NC-ND 3.0 licence true eng https://creativecommons.org/licenses/by-nc-nd/3.0/
title Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
spellingShingle Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
Erifyli Piastopoulou
Parvaiz Ali
Chandramohan Murugesan
Gareth Stratton
Michael Lewis
title_short Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
title_full Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
title_fullStr Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
title_full_unstemmed Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
title_sort Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
author_id_str_mv 1bcaddedf0a3484b64cc4df6ee9b07d5
d03adb0b0294cba80e020e423903caa6
e003fb59a193203e6949459dd27cf0bb
6d62b2ed126961bed81a94a2beba8a01
b59c8f5c056bac7e6995385f22ad1639
author_id_fullname_str_mv 1bcaddedf0a3484b64cc4df6ee9b07d5_***_Erifyli Piastopoulou
d03adb0b0294cba80e020e423903caa6_***_Parvaiz Ali
e003fb59a193203e6949459dd27cf0bb_***_Chandramohan Murugesan
6d62b2ed126961bed81a94a2beba8a01_***_Gareth Stratton
b59c8f5c056bac7e6995385f22ad1639_***_Michael Lewis
author Erifyli Piastopoulou
Parvaiz Ali
Chandramohan Murugesan
Gareth Stratton
Michael Lewis
author2 Erifyli Piastopoulou
Parvaiz Ali
Gianfilippo Bertelli
Martyn Heatley
Maung Moe
Chandramohan Murugesan
Gareth Stratton
Michael Lewis
format Journal article
container_title Physiological Measurement
container_volume 42
container_issue 10
institution Swansea University
issn 0967-3334
1361-6579
doi_str_mv 10.1088/1361-6579/ac28e5
publisher IOP Publishing
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 1
active_str 0
description Objective: Breast cancer treatment can negatively impact cardiac function in some breast cancer patients. Current methods (MUGA, echocardiography) used in clinical practice to detect abnormal cardiac changes as a result of treatment suffer from important limitations. Use of alternative techniques that would offer safe, inexpensive and non-invasive cardiac function assessment in this population would be highly advantageous. The aim of this study was to examine the agreement between impedance cardiography (ICG) and cardiac magnetic resonance imaging (CMR) in quantifying stroke volume (SV), cardiac output (CO) and end-diastolic volume (EDV) in this population. Approach: Sixteen breast cancer patients underwent ICG and CMR assessments at three time-points (before treatment, immediately after chemotherapy, and four months after chemotherapy). Bland-Altman analysis was used to quantify the accuracy and precision of ICG (relative to CMR) in estimating absolute values of SV, CO and EDV. Four methods (concordance rate, polar concordance rate, clinical concordance rate and trend interchangeability rate) were also used to assess ICG performance in tracking changes in these variables. Main results: Bland-Altman analysis showed that the accuracy of ICG relative to CMR was -3.1 ml (SV), 0.2 L·min-1 (CO) and -26.0 ml (EDV) and precision was 13.2 ml (SV), 1.1 L·min-1 (CO) and 20.1 ml (EDV), respectively. Trending ability assessment showed that 1) the concordance rate was 87% (SV), 73% (CO) and 73% (EDV), 2) the polar concordance rate was 67% (SV), 53% (CO) and 33% (EDV), 3) the clinical concordance rate was 33% (SV), 40% (CO) and 20% (EDV) and 4) the trend interchangeability rate was 29% (SV), 43% (CO) and 17% (EDV), respectively. Significance: Our findings show that, although ICG showed good accuracy for absolute SV and CO measurements and for CO and EDV changes, precision was poor for all variables in terms of both absolute measurements and trend tracking performance. This suggests that ICG cannot be used interchangeably with CMR in breast cancer patients.
published_date 0001-01-01T04:14:23Z
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