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Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data

Joanna F. Dipnall, Frederick P. Rivara, Ronan Lyons Orcid Logo, Shanthi Ameratunga, Mariana Brussoni, Fiona E. Lecky, Clare Bradley, Ben Beck, Jane Lyons, Amy Schneeberg, James E. Harrison, Belinda Gabbe Orcid Logo

International Journal of Environmental Research and Public Health, Volume: 18, Issue: 19, Start page: 10156

Swansea University Authors: Ronan Lyons Orcid Logo, Jane Lyons, Belinda Gabbe Orcid Logo

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Abstract

Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at b...

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Published in: International Journal of Environmental Research and Public Health
ISSN: 1660-4601
Published: MDPI AG 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa58149
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Abstract: Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population.
Keywords: health-related quality of life, health outcomes, disability, trauma, injury, EQ-5D, children, pediatric, adolescents
College: Swansea University Medical School
Funders: National Health and Medical Research Council of Australia Grant: NHMRC-APP1142325 Grant: (#0010009) Grant: NA Grant: NA Grant: NA Grant: NA Grant: (FT170100048) Canadian Institutes of Health Research Grant: (#TIR-104028) Michael Smith Foundation for Health Research Grant: NA
Issue: 19
Start Page: 10156