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A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer

Samira Behboudi-Gandevani, Razieh Bidhendi-Yarandi, Mohammad Hossein Panahi, Mojtaba Vaismoradi

Frontiers in Oncology, Volume: 11

Swansea University Author: Mojtaba Vaismoradi

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DOI (Published version): 10.3389/fonc.2021.696702

Abstract

Objectives: The primary objective of this systemic review and meta-analysis was to investigate the risk of developing composite outcome of all cancers, regardless of the type of cancer among men with infertility diagnosis compared to fertile counterparts. The secondary objective was to compare the p...

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Published in: Frontiers in Oncology
ISSN: 2234-943X
Published: Frontiers Media SA 2021
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2021-11-09T12:13:58.8617782</datestamp><bib-version>v2</bib-version><id>58323</id><entry>2021-10-14</entry><title>A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer</title><swanseaauthors><author><sid>b865b33654e99f5cbccdb11350f7b069</sid><firstname>Mojtaba</firstname><surname>Vaismoradi</surname><name>Mojtaba Vaismoradi</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2021-10-14</date><deptcode>FGMHL</deptcode><abstract>Objectives: The primary objective of this systemic review and meta-analysis was to investigate the risk of developing composite outcome of all cancers, regardless of the type of cancer among men with infertility diagnosis compared to fertile counterparts. The secondary objective was to compare the pooled risk of developing individual specific cancers between two groups.Methods: A systematic literature search was performed on the databases of PubMed (including Medline), Scopus, and Web of Science to retrieve observational studies published in English language from 01.01.1990 to 28. 02. 2021. They assessed cancer events in males with an infertility diagnosis compared to controls without infertility. The outcomes of interest were a composite outcome of cancers including all known cancer types, and also specific individual cancers. The fixed/random effects model was used to analyze heterogeneous and non-heterogeneous results. Publication bias was assessed using the Harbord test, Egger test, Begg test, and funnel plot. The pooled odds ratio of cancers was calculated using the DerSimonian and Laird, and inverse variance methods. Studies&#x2019; quality and risk of bias were assessed using structured standard tools.Results: We included eight cohort studies involving 168,327 men with the diagnosis of infertility and 2,252,806 men without it. The total number of composite outcome of cancers as well as individual cancers including prostate, testicular and melanoma were 1551, 324, 183 and 121 in the infertile men and 12164, 3875, 849, and 450 in the fertile men, respectively. The pooled OR of the composite outcome of cancers, regardless of the type of cancer, in men with infertility was 1.4 folds higher than those without infertility (pooled OR = 1.43, 95% confidence interval [CI]: 1.25-1.64). Meta-analysis of individual cancers including prostate, testicular and melanoma between two groups was carried out. The pooled ORs of testicular and prostate cancers in men with the diagnosis of infertility were significantly higher than controls without infertility (pooled OR = 1.91, 95% CI: 1.52-2.42 and pooled OR = 1.48, 95% CI: 1.05-2.08, respectively). Additionally, the pooled OR of melanoma in men with infertility was 1.3 folds higher than those without infertility (pooled OR = 1.31, 95% CI: 1.06-1.62).Conclusion: A greater risk of cancers in men with male infertility was found suggesting that the history of male infertility might be an important risk factor for developing cancers in later life. Further well-designed long-term population-based prospective studies, considering all known cancers and their accompanying risk factors should be conducted to support our findings.</abstract><type>Journal Article</type><journal>Frontiers in Oncology</journal><volume>11</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Frontiers Media SA</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2234-943X</issnElectronic><keywords>melanoma; prostate cancer; risk; testicular cancer; male infertility</keywords><publishedDay>14</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-10-14</publishedDate><doi>10.3389/fonc.2021.696702</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine, Health and Life Science - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGMHL</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>Nord University</funders><lastEdited>2021-11-09T12:13:58.8617782</lastEdited><Created>2021-10-14T07:57:34.9456704</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Nursing</level></path><authors><author><firstname>Samira</firstname><surname>Behboudi-Gandevani</surname><order>1</order></author><author><firstname>Razieh</firstname><surname>Bidhendi-Yarandi</surname><order>2</order></author><author><firstname>Mohammad Hossein</firstname><surname>Panahi</surname><order>3</order></author><author><firstname>Mojtaba</firstname><surname>Vaismoradi</surname><order>4</order></author></authors><documents><document><filename>58323__21169__471269b6d74b4bf6be8732e94303df54.pdf</filename><originalFilename>fonc-11-696702.pdf</originalFilename><uploaded>2021-10-14T08:01:42.4313780</uploaded><type>Output</type><contentLength>1664514</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; 2021 Behboudi-Gandevani, Bidhendi-Yarandi, Panahi and Vaismoradi. 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spelling 2021-11-09T12:13:58.8617782 v2 58323 2021-10-14 A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer b865b33654e99f5cbccdb11350f7b069 Mojtaba Vaismoradi Mojtaba Vaismoradi true false 2021-10-14 FGMHL Objectives: The primary objective of this systemic review and meta-analysis was to investigate the risk of developing composite outcome of all cancers, regardless of the type of cancer among men with infertility diagnosis compared to fertile counterparts. The secondary objective was to compare the pooled risk of developing individual specific cancers between two groups.Methods: A systematic literature search was performed on the databases of PubMed (including Medline), Scopus, and Web of Science to retrieve observational studies published in English language from 01.01.1990 to 28. 02. 2021. They assessed cancer events in males with an infertility diagnosis compared to controls without infertility. The outcomes of interest were a composite outcome of cancers including all known cancer types, and also specific individual cancers. The fixed/random effects model was used to analyze heterogeneous and non-heterogeneous results. Publication bias was assessed using the Harbord test, Egger test, Begg test, and funnel plot. The pooled odds ratio of cancers was calculated using the DerSimonian and Laird, and inverse variance methods. Studies’ quality and risk of bias were assessed using structured standard tools.Results: We included eight cohort studies involving 168,327 men with the diagnosis of infertility and 2,252,806 men without it. The total number of composite outcome of cancers as well as individual cancers including prostate, testicular and melanoma were 1551, 324, 183 and 121 in the infertile men and 12164, 3875, 849, and 450 in the fertile men, respectively. The pooled OR of the composite outcome of cancers, regardless of the type of cancer, in men with infertility was 1.4 folds higher than those without infertility (pooled OR = 1.43, 95% confidence interval [CI]: 1.25-1.64). Meta-analysis of individual cancers including prostate, testicular and melanoma between two groups was carried out. The pooled ORs of testicular and prostate cancers in men with the diagnosis of infertility were significantly higher than controls without infertility (pooled OR = 1.91, 95% CI: 1.52-2.42 and pooled OR = 1.48, 95% CI: 1.05-2.08, respectively). Additionally, the pooled OR of melanoma in men with infertility was 1.3 folds higher than those without infertility (pooled OR = 1.31, 95% CI: 1.06-1.62).Conclusion: A greater risk of cancers in men with male infertility was found suggesting that the history of male infertility might be an important risk factor for developing cancers in later life. Further well-designed long-term population-based prospective studies, considering all known cancers and their accompanying risk factors should be conducted to support our findings. Journal Article Frontiers in Oncology 11 Frontiers Media SA 2234-943X melanoma; prostate cancer; risk; testicular cancer; male infertility 14 10 2021 2021-10-14 10.3389/fonc.2021.696702 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University Another institution paid the OA fee Nord University 2021-11-09T12:13:58.8617782 2021-10-14T07:57:34.9456704 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing Samira Behboudi-Gandevani 1 Razieh Bidhendi-Yarandi 2 Mohammad Hossein Panahi 3 Mojtaba Vaismoradi 4 58323__21169__471269b6d74b4bf6be8732e94303df54.pdf fonc-11-696702.pdf 2021-10-14T08:01:42.4313780 Output 1664514 application/pdf Version of Record true © 2021 Behboudi-Gandevani, Bidhendi-Yarandi, Panahi and Vaismoradi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) true eng http://creativecommons.org/licenses/by/4.0/
title A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer
spellingShingle A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer
Mojtaba Vaismoradi
title_short A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer
title_full A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer
title_fullStr A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer
title_full_unstemmed A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer
title_sort A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer
author_id_str_mv b865b33654e99f5cbccdb11350f7b069
author_id_fullname_str_mv b865b33654e99f5cbccdb11350f7b069_***_Mojtaba Vaismoradi
author Mojtaba Vaismoradi
author2 Samira Behboudi-Gandevani
Razieh Bidhendi-Yarandi
Mohammad Hossein Panahi
Mojtaba Vaismoradi
format Journal article
container_title Frontiers in Oncology
container_volume 11
publishDate 2021
institution Swansea University
issn 2234-943X
doi_str_mv 10.3389/fonc.2021.696702
publisher Frontiers Media SA
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
document_store_str 1
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description Objectives: The primary objective of this systemic review and meta-analysis was to investigate the risk of developing composite outcome of all cancers, regardless of the type of cancer among men with infertility diagnosis compared to fertile counterparts. The secondary objective was to compare the pooled risk of developing individual specific cancers between two groups.Methods: A systematic literature search was performed on the databases of PubMed (including Medline), Scopus, and Web of Science to retrieve observational studies published in English language from 01.01.1990 to 28. 02. 2021. They assessed cancer events in males with an infertility diagnosis compared to controls without infertility. The outcomes of interest were a composite outcome of cancers including all known cancer types, and also specific individual cancers. The fixed/random effects model was used to analyze heterogeneous and non-heterogeneous results. Publication bias was assessed using the Harbord test, Egger test, Begg test, and funnel plot. The pooled odds ratio of cancers was calculated using the DerSimonian and Laird, and inverse variance methods. Studies’ quality and risk of bias were assessed using structured standard tools.Results: We included eight cohort studies involving 168,327 men with the diagnosis of infertility and 2,252,806 men without it. The total number of composite outcome of cancers as well as individual cancers including prostate, testicular and melanoma were 1551, 324, 183 and 121 in the infertile men and 12164, 3875, 849, and 450 in the fertile men, respectively. The pooled OR of the composite outcome of cancers, regardless of the type of cancer, in men with infertility was 1.4 folds higher than those without infertility (pooled OR = 1.43, 95% confidence interval [CI]: 1.25-1.64). Meta-analysis of individual cancers including prostate, testicular and melanoma between two groups was carried out. The pooled ORs of testicular and prostate cancers in men with the diagnosis of infertility were significantly higher than controls without infertility (pooled OR = 1.91, 95% CI: 1.52-2.42 and pooled OR = 1.48, 95% CI: 1.05-2.08, respectively). Additionally, the pooled OR of melanoma in men with infertility was 1.3 folds higher than those without infertility (pooled OR = 1.31, 95% CI: 1.06-1.62).Conclusion: A greater risk of cancers in men with male infertility was found suggesting that the history of male infertility might be an important risk factor for developing cancers in later life. Further well-designed long-term population-based prospective studies, considering all known cancers and their accompanying risk factors should be conducted to support our findings.
published_date 2021-10-14T04:14:45Z
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