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Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes

Zoe Marshall, Kelly Mackintosh Orcid Logo, John W. Gregory, Melitta McNarry Orcid Logo

Pediatric Diabetes, Volume: 23, Issue: 1, Pages: 115 - 125

Swansea University Authors: Zoe Marshall, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo

  • Accepted Manuscript under embargo until: 15th November 2022
  • Supplemental material under embargo until: 15th November 2022
  • Supplemental material under embargo until: 15th November 2022

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DOI (Published version): 10.1111/pedi.13288

Abstract

The aim of this study was to use a compositional analysis approach to account for the inherent co-dependencies between behaviours and to explore how daily movement behaviours influence cardiovascular health in children with and without T1D. Augmentation index, pulse wave velocity (PWV) and heart rat...

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Published in: Pediatric Diabetes
ISSN: 1399-543X 1399-5448
Published: Wiley 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa58495
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spelling 2022-01-24T13:14:21.5521800 v2 58495 2021-10-28 Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes c5ddb01098ac73242456f06a6b6ed7e2 Zoe Marshall Zoe Marshall true false bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 2021-10-28 FGSEN The aim of this study was to use a compositional analysis approach to account for the inherent co-dependencies between behaviours and to explore how daily movement behaviours influence cardiovascular health in children with and without T1D. Augmentation index, pulse wave velocity (PWV) and heart rate variability were measured in 20 children with (11.9±1.6 years) and 17 children without T1D (11.6±2.2 years). Subsequently, physical activity and sleep were assessed at 20 Hz for 28 consecutive days using a wrist-worn accelerometer. Compositional analyses were utilised to explore the relative effects of each movement behaviour and the overall movement complex on cardiovascular parameters, with predictive modelling used to explore the effects of reallocating 20 mins between behaviours. Arterial stiffness markers were most influenced by the total movement composition, whereas autonomic function was most influenced by sedentary time and sleep relative to all other behaviours. Reallocation of time from moderate-to-vigorous physical activity (MVPA) to any other behaviour was predicted to negatively affect all cardiovascular measures, independent of disease status, whereas reallocating time to MVPA was consistently predicted to improve all outcome measures. Additionally, the same intensity of physical activity appeared to be more potent for cardiovascular health in T1D children compared to non-diabetic peers.Intensity, rather than volume, of physical activity may be key in reducing risk of premature adverse changes in cardiovascular health, whereas increasing time in MVPA could potentially the slow progression of cardiovascular aging in children with diabetes. Journal Article Pediatric Diabetes 23 1 115 125 Wiley 1399-543X 1399-5448 arterial stiffness; heart rate variability; paediatric; sedentary; youth 1 2 2022 2022-02-01 10.1111/pedi.13288 COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University 2022-01-24T13:14:21.5521800 2021-10-28T14:08:07.8998663 College of Engineering Sports Science Zoe Marshall 1 Kelly Mackintosh 0000-0003-0355-6357 2 John W. Gregory 3 Melitta McNarry 0000-0003-0813-7477 4 Under embargo Under embargo 2021-10-28T14:13:30.6639947 Output 311268 application/pdf Accepted Manuscript true 2022-11-15T00:00:00.0000000 true eng Under embargo Under embargo 2021-10-28T14:13:57.8898192 Output 101641 application/pdf Supplemental material true 2022-11-15T00:00:00.0000000 true eng Under embargo Under embargo 2021-10-28T14:14:26.1679024 Output 85545 application/pdf Supplemental material true 2022-11-15T00:00:00.0000000 true eng
title Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes
spellingShingle Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes
Zoe Marshall
Kelly Mackintosh
Melitta McNarry
title_short Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes
title_full Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes
title_fullStr Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes
title_full_unstemmed Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes
title_sort Using compositional analysis to explore the relationship between physical activity and cardiovascular health in children and adolescents with and without type 1 diabetes
author_id_str_mv c5ddb01098ac73242456f06a6b6ed7e2
bdb20e3f31bcccf95c7bc116070c4214
062f5697ff59f004bc8c713955988398
author_id_fullname_str_mv c5ddb01098ac73242456f06a6b6ed7e2_***_Zoe Marshall
bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
062f5697ff59f004bc8c713955988398_***_Melitta McNarry
author Zoe Marshall
Kelly Mackintosh
Melitta McNarry
author2 Zoe Marshall
Kelly Mackintosh
John W. Gregory
Melitta McNarry
format Journal article
container_title Pediatric Diabetes
container_volume 23
container_issue 1
container_start_page 115
publishDate 2022
institution Swansea University
issn 1399-543X
1399-5448
doi_str_mv 10.1111/pedi.13288
publisher Wiley
college_str College of Engineering
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hierarchy_top_title College of Engineering
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hierarchy_parent_title College of Engineering
department_str Sports Science{{{_:::_}}}College of Engineering{{{_:::_}}}Sports Science
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description The aim of this study was to use a compositional analysis approach to account for the inherent co-dependencies between behaviours and to explore how daily movement behaviours influence cardiovascular health in children with and without T1D. Augmentation index, pulse wave velocity (PWV) and heart rate variability were measured in 20 children with (11.9±1.6 years) and 17 children without T1D (11.6±2.2 years). Subsequently, physical activity and sleep were assessed at 20 Hz for 28 consecutive days using a wrist-worn accelerometer. Compositional analyses were utilised to explore the relative effects of each movement behaviour and the overall movement complex on cardiovascular parameters, with predictive modelling used to explore the effects of reallocating 20 mins between behaviours. Arterial stiffness markers were most influenced by the total movement composition, whereas autonomic function was most influenced by sedentary time and sleep relative to all other behaviours. Reallocation of time from moderate-to-vigorous physical activity (MVPA) to any other behaviour was predicted to negatively affect all cardiovascular measures, independent of disease status, whereas reallocating time to MVPA was consistently predicted to improve all outcome measures. Additionally, the same intensity of physical activity appeared to be more potent for cardiovascular health in T1D children compared to non-diabetic peers.Intensity, rather than volume, of physical activity may be key in reducing risk of premature adverse changes in cardiovascular health, whereas increasing time in MVPA could potentially the slow progression of cardiovascular aging in children with diabetes.
published_date 2022-02-01T04:36:19Z
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