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Protocol for the development of a core outcome set for studies of pregnant women with pre-existing multimorbidity

Siang Ing Lee, Kelly-Ann Eastwood, Ngawai Moss, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Astha Anand, Beck Taylor, Catherine Nelson-Piercy, Christopher Yau, Colin McCowan, Dermot O'Reilly, Holly Hope, Jonathan Kennedy, Kathryn Mary Abel, Louise Locock, Peter Brocklehurst, Rachel Plachcinski, Sinead Brophy Orcid Logo, Utkarsh Agrawal, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Mairead Black

BMJ Open, Volume: 11, Issue: 10, Start page: e044919

Swansea University Authors: Jonathan Kennedy, Sinead Brophy Orcid Logo

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Abstract

Increasingly more pregnant women are living with pre-existing multimorbidity (≥two long-term physical or mental health conditions). This may adversely affect maternal and offspring outcomes. This study aims to develop a core outcome set (COS) for maternal and offspring outcomes in pregnant women wit...

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Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa58679
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Abstract: Increasingly more pregnant women are living with pre-existing multimorbidity (≥two long-term physical or mental health conditions). This may adversely affect maternal and offspring outcomes. This study aims to develop a core outcome set (COS) for maternal and offspring outcomes in pregnant women with pre-existing multimorbidity. It is intended for use in observational and interventional studies in all pregnancy settings. We propose a four stage study design: (1) systematic literature search, (2) focus groups, (3) Delphi surveys and (4) consensus group meeting. The study will be conducted from June 2021 to August 2022. First, an initial list of outcomes will be identified through a systematic literature search of reported outcomes in studies of pregnant women with multimorbidity. We will search the Cochrane library, Medline, EMBASE and CINAHL. This will be supplemented with relevant outcomes from published COS for pregnancies and childbirth in general, and multimorbidity. Second, focus groups will be conducted among (1) women with lived experience of managing pre-existing multimorbidity in pregnancy (and/or their partners) and (2) their healthcare/social care professionals to identify outcomes important to them. Third, these initial lists of outcomes will be prioritised through a three-round online Delphi survey using predefined score criteria for consensus. Participants will be invited to suggest additional outcomes that were not included in the initial list. Finally, a consensus meeting using the nominal group technique will be held to agree on the final COS. The stakeholders will include (1) women (and/or their partners) with lived experience of managing multimorbidity in pregnancy, (2) healthcare/social care professionals involved in their care and (3) researchers in this field. This study has been approved by the University of Birmingham's ethical review committee. The final COS will be disseminated through peer-reviewed publication and conferences and to all stakeholders. [Abstract copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.]
Keywords: Outcome Assessment, Health Care, public health, Pregnant Women, Female, Pregnancy, Multimorbidity, Parturition, maternal medicine, Research Design, Delphi Technique, Humans, preventive medicine
College: Faculty of Medicine, Health and Life Sciences
Funders: Medical Research Council Grant: MR/V005243/1
Issue: 10
Start Page: e044919