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A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives

Marc Evans, Ruth D. Lewis, Angharad R. Morgan, Martin B. Whyte, Wasim Hanif, Steve Bain Orcid Logo, Sarah Davies, Umesh Dashora, Zaheer Yousef, Dipesh C. Patel, W. David Strain

Advances in Therapy, Volume: 39, Issue: 1, Pages: 33 - 43

Swansea University Author: Steve Bain Orcid Logo

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DOI (Published version): 10.1007/s12325-021-01927-z

Abstract

Chronic kidney disease (CKD) is a complex disease which affects approximately 13% of the world's population. Over time, CKD can cause renal dysfunction and progression to end-stage kidney disease and cardiovascular disease. Complications associated with CKD may contribute to the acceleration of...

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Published in: Advances in Therapy
ISSN: 0741-238X 1865-8652
Published: Springer Science and Business Media LLC 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa58735
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first_indexed 2021-11-22T11:28:29Z
last_indexed 2022-03-17T04:27:21Z
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spelling 2022-03-16T11:38:58.3506881 v2 58735 2021-11-22 A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives 5399f4c6e6a70f3608a084ddb938511a 0000-0001-8519-4964 Steve Bain Steve Bain true false 2021-11-22 BMS Chronic kidney disease (CKD) is a complex disease which affects approximately 13% of the world's population. Over time, CKD can cause renal dysfunction and progression to end-stage kidney disease and cardiovascular disease. Complications associated with CKD may contribute to the acceleration of disease progression and the risk of cardiovascular-related morbidities. Early CKD is asymptomatic, and symptoms only present at later stages when complications of the disease arise, such as a decline in kidney function and the presence of other comorbidities associated with the disease. In advanced stages of the disease, when kidney function is significantly impaired, patients can only be treated with dialysis or a transplant. With limited treatment options available, an increasing prevalence of both the elderly population and comorbidities associated with the disease, the prevalence of CKD is set to rise. This review discusses the current challenges and the unmet patient need in CKD. Journal Article Advances in Therapy 39 1 33 43 Springer Science and Business Media LLC 0741-238X 1865-8652 Cardiovascular disease, Chronic kidney disease, Diabetic kidney disease, Sodium–glucose co-transporter 2 inhibitors 1 1 2022 2022-01-01 10.1007/s12325-021-01927-z COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Other AstraZeneca UK Ltd 2022-03-16T11:38:58.3506881 2021-11-22T11:26:29.9041027 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Marc Evans 1 Ruth D. Lewis 2 Angharad R. Morgan 3 Martin B. Whyte 4 Wasim Hanif 5 Steve Bain 0000-0001-8519-4964 6 Sarah Davies 7 Umesh Dashora 8 Zaheer Yousef 9 Dipesh C. Patel 10 W. David Strain 11 58735__21622__f384d308918d4b9f8e7868e8fa280f9f.pdf 58735.pdf 2021-11-22T11:27:58.1719750 Output 361930 application/pdf Version of Record true Copyright: The Author(s) 2021. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License true eng http://creativecommons.org/licenses/by-nc/4.0/
title A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives
spellingShingle A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives
Steve Bain
title_short A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives
title_full A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives
title_fullStr A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives
title_full_unstemmed A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives
title_sort A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives
author_id_str_mv 5399f4c6e6a70f3608a084ddb938511a
author_id_fullname_str_mv 5399f4c6e6a70f3608a084ddb938511a_***_Steve Bain
author Steve Bain
author2 Marc Evans
Ruth D. Lewis
Angharad R. Morgan
Martin B. Whyte
Wasim Hanif
Steve Bain
Sarah Davies
Umesh Dashora
Zaheer Yousef
Dipesh C. Patel
W. David Strain
format Journal article
container_title Advances in Therapy
container_volume 39
container_issue 1
container_start_page 33
publishDate 2022
institution Swansea University
issn 0741-238X
1865-8652
doi_str_mv 10.1007/s12325-021-01927-z
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description Chronic kidney disease (CKD) is a complex disease which affects approximately 13% of the world's population. Over time, CKD can cause renal dysfunction and progression to end-stage kidney disease and cardiovascular disease. Complications associated with CKD may contribute to the acceleration of disease progression and the risk of cardiovascular-related morbidities. Early CKD is asymptomatic, and symptoms only present at later stages when complications of the disease arise, such as a decline in kidney function and the presence of other comorbidities associated with the disease. In advanced stages of the disease, when kidney function is significantly impaired, patients can only be treated with dialysis or a transplant. With limited treatment options available, an increasing prevalence of both the elderly population and comorbidities associated with the disease, the prevalence of CKD is set to rise. This review discusses the current challenges and the unmet patient need in CKD.
published_date 2022-01-01T04:15:30Z
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score 11.012947

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