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The cross‐sectional interplay between neurochemical profile and brain connectivity
Human Brain Mapping, Volume: 42, Issue: 9, Pages: 2722 - 2733
Swansea University Author: George Zacharopoulos
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DOI (Published version): 10.1002/hbm.25396
Abstract
Neurochemical profile and brain connectivity are both critical aspects of brain function. However, our knowledge of their interplay across development is currently poor. We combined single-voxel magnetic resonance spectroscopy and resting functional magnetic resonance imaging in a cross-sectional sa...
Published in: | Human Brain Mapping |
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ISSN: | 1065-9471 1097-0193 |
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Wiley
2021
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URI: | https://cronfa.swan.ac.uk/Record/cronfa58961 |
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v2 58961 2021-12-07 The cross‐sectional interplay between neurochemical profile and brain connectivity 7abcfe5e6fd29d20e2c53eff9a4098d1 George Zacharopoulos George Zacharopoulos true false 2021-12-07 HPS Neurochemical profile and brain connectivity are both critical aspects of brain function. However, our knowledge of their interplay across development is currently poor. We combined single-voxel magnetic resonance spectroscopy and resting functional magnetic resonance imaging in a cross-sectional sample spanning from childhood to adulthood which was reassessed in ~1.5 years (N = 293). We revealed the developmental trajectories of 20 neurochemicals in two key developmental brain regions (the intraparietal sulcus, IPS, and the middle frontal gyrus, MFG). We found that certain neurochemicals exhibited similar developmental trajectories across the two regions, while other trajectories were region-specific. Crucially, we mapped the connectivity of the brain regions IPS and MFG to the rest of the brain across development as a function of regional glutamate and GABA concentration. We demonstrated that glutamate concentration within the IPS is modulated by age in explaining IPS connectivity with frontal, temporal and parietal regions. In mature participants, higher glutamate within the IPS was related to more negative connectivity while the opposite pattern was found for younger participants. Our findings offer specific developmental insights on the interplay between the brain's resting activity and the glutamatergic system both of which are crucial for regulating normal functioning and are dysregulated in several clinical conditions. Journal Article Human Brain Mapping 42 9 2722 2733 Wiley 1065-9471 1097-0193 brain connectivity; development; glutamate; neurochemicals; parietal 15 6 2021 2021-06-15 10.1002/hbm.25396 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University FP7 Ideas: European Research Council. Grant Number: 338065; Wellcome Trust. Grant Number: 203139/Z/16/Z 2023-09-13T17:16:34.9329882 2021-12-07T14:28:21.2146430 Faculty of Medicine, Health and Life Sciences School of Psychology George Zacharopoulos 1 Uzay Emir 2 Roi Cohen Kadosh 3 58961__21962__619a25ccf657410fbd3f2b5874bec49a.pdf 58961.pdf 2021-12-30T10:08:06.0451087 Output 3816728 application/pdf Version of Record true © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/ |
title |
The cross‐sectional interplay between neurochemical profile and brain connectivity |
spellingShingle |
The cross‐sectional interplay between neurochemical profile and brain connectivity George Zacharopoulos |
title_short |
The cross‐sectional interplay between neurochemical profile and brain connectivity |
title_full |
The cross‐sectional interplay between neurochemical profile and brain connectivity |
title_fullStr |
The cross‐sectional interplay between neurochemical profile and brain connectivity |
title_full_unstemmed |
The cross‐sectional interplay between neurochemical profile and brain connectivity |
title_sort |
The cross‐sectional interplay between neurochemical profile and brain connectivity |
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7abcfe5e6fd29d20e2c53eff9a4098d1 |
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7abcfe5e6fd29d20e2c53eff9a4098d1_***_George Zacharopoulos |
author |
George Zacharopoulos |
author2 |
George Zacharopoulos Uzay Emir Roi Cohen Kadosh |
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Journal article |
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Human Brain Mapping |
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42 |
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9 |
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2722 |
publishDate |
2021 |
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Swansea University |
issn |
1065-9471 1097-0193 |
doi_str_mv |
10.1002/hbm.25396 |
publisher |
Wiley |
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Faculty of Medicine, Health and Life Sciences |
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Faculty of Medicine, Health and Life Sciences |
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Faculty of Medicine, Health and Life Sciences |
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School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology |
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description |
Neurochemical profile and brain connectivity are both critical aspects of brain function. However, our knowledge of their interplay across development is currently poor. We combined single-voxel magnetic resonance spectroscopy and resting functional magnetic resonance imaging in a cross-sectional sample spanning from childhood to adulthood which was reassessed in ~1.5 years (N = 293). We revealed the developmental trajectories of 20 neurochemicals in two key developmental brain regions (the intraparietal sulcus, IPS, and the middle frontal gyrus, MFG). We found that certain neurochemicals exhibited similar developmental trajectories across the two regions, while other trajectories were region-specific. Crucially, we mapped the connectivity of the brain regions IPS and MFG to the rest of the brain across development as a function of regional glutamate and GABA concentration. We demonstrated that glutamate concentration within the IPS is modulated by age in explaining IPS connectivity with frontal, temporal and parietal regions. In mature participants, higher glutamate within the IPS was related to more negative connectivity while the opposite pattern was found for younger participants. Our findings offer specific developmental insights on the interplay between the brain's resting activity and the glutamatergic system both of which are crucial for regulating normal functioning and are dysregulated in several clinical conditions. |
published_date |
2021-06-15T17:16:37Z |
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11.012678 |