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Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering

George Zacharopoulos, Torkel Klingberg, Roi Cohen Kadosh

Cognitive Neuroscience, Volume: 11, Issue: 4, Pages: 229 - 238

Swansea University Author: George Zacharopoulos

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DOI (Published version): 10.1080/17588928.2020.1813699

Abstract

Cognitive control is a pivotal aspect of cognition and it is impaired in many clinical populations. To date, several distinct types of cognitive control have been proposed, and prior work demonstrated the instrumental role of basal ganglia, frontal and parietal regions. However, the role of the stru...

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Published in: Cognitive Neuroscience
ISSN: 1758-8928 1758-8936
Published: Informa UK Limited 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa58963
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spelling 2021-12-29T16:57:35.2528012 v2 58963 2021-12-07 Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering 7abcfe5e6fd29d20e2c53eff9a4098d1 George Zacharopoulos George Zacharopoulos true false 2021-12-07 HPS Cognitive control is a pivotal aspect of cognition and it is impaired in many clinical populations. To date, several distinct types of cognitive control have been proposed, and prior work demonstrated the instrumental role of basal ganglia, frontal and parietal regions. However, the role of the structural variation of these regions in cognitive control functions is poorly understood. Here, we examined in 39 adults the association between regional brain volume and three major types of cognitive control: (i) stimulus updating, (ii) task-switching, and (iii) distractor filtering. The volume of the globus pallidus was positively correlated with individual variation in task-switching , and was anatomically specific to the left hemisphere. Importantly, this region did not track performance in distractor filtering or stimulus updating. We then aimed to use transcranial direct current stimulation to target the left midline subcortical structures. However, we did not find an effect on task-switching. While the null effect in the brain stimulation prevents us from drawing causal inference from the role of globus pallidus on task-switching, our structural results reveal a novel and highly specific neurostructural mechanism for task-switching and provide a further understanding of the link between cognitive control functions and the human brain. Journal Article Cognitive Neuroscience 11 4 229 238 Informa UK Limited 1758-8928 1758-8936 Working-memory; task-switching; globus pallidus 10 10 2020 2020-10-10 10.1080/17588928.2020.1813699 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University European Research Council under Grant Learning & Achievement (338065) 2021-12-29T16:57:35.2528012 2021-12-07T14:29:25.2073185 Faculty of Medicine, Health and Life Sciences School of Psychology George Zacharopoulos 1 Torkel Klingberg 2 Roi Cohen Kadosh 3 58963__21954__e26b9164edd5436c8412f826eb40322a.pdf 58963.pdf 2021-12-29T16:55:18.0324762 Output 1707085 application/pdf Version of Record true © 2020 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering
spellingShingle Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering
George Zacharopoulos
title_short Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering
title_full Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering
title_fullStr Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering
title_full_unstemmed Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering
title_sort Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering
author_id_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1
author_id_fullname_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1_***_George Zacharopoulos
author George Zacharopoulos
author2 George Zacharopoulos
Torkel Klingberg
Roi Cohen Kadosh
format Journal article
container_title Cognitive Neuroscience
container_volume 11
container_issue 4
container_start_page 229
publishDate 2020
institution Swansea University
issn 1758-8928
1758-8936
doi_str_mv 10.1080/17588928.2020.1813699
publisher Informa UK Limited
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
active_str 0
description Cognitive control is a pivotal aspect of cognition and it is impaired in many clinical populations. To date, several distinct types of cognitive control have been proposed, and prior work demonstrated the instrumental role of basal ganglia, frontal and parietal regions. However, the role of the structural variation of these regions in cognitive control functions is poorly understood. Here, we examined in 39 adults the association between regional brain volume and three major types of cognitive control: (i) stimulus updating, (ii) task-switching, and (iii) distractor filtering. The volume of the globus pallidus was positively correlated with individual variation in task-switching , and was anatomically specific to the left hemisphere. Importantly, this region did not track performance in distractor filtering or stimulus updating. We then aimed to use transcranial direct current stimulation to target the left midline subcortical structures. However, we did not find an effect on task-switching. While the null effect in the brain stimulation prevents us from drawing causal inference from the role of globus pallidus on task-switching, our structural results reveal a novel and highly specific neurostructural mechanism for task-switching and provide a further understanding of the link between cognitive control functions and the human brain.
published_date 2020-10-10T04:15:54Z
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