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The genetics of neuroticism and human values

George Zacharopoulos, Thomas M. Lancaster, Gregory R. Maio, David E. J. Linden

Genes, Brain and Behavior, Volume: 15, Issue: 4, Pages: 361 - 366

Swansea University Author: George Zacharopoulos

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DOI (Published version): 10.1111/gbb.12286

Abstract

Human values and personality have been shown to share genetic variance in twin studies. However, there is a lack of evidence about the genetic components of this association. This study examined the interplay between genes, values and personality in the case of neuroticism, because polygenic scores...

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Published in: Genes, Brain and Behavior
ISSN: 1601-1848
Published: Wiley 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa58968
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spelling 2021-12-29T15:32:40.5225864 v2 58968 2021-12-07 The genetics of neuroticism and human values 7abcfe5e6fd29d20e2c53eff9a4098d1 George Zacharopoulos George Zacharopoulos true false 2021-12-07 HPS Human values and personality have been shown to share genetic variance in twin studies. However, there is a lack of evidence about the genetic components of this association. This study examined the interplay between genes, values and personality in the case of neuroticism, because polygenic scores were available for this personality trait. First, we replicated prior evidence of a positive association between the polygenic neuroticism score (PNS) and neuroticism. Second, we found that the PNS was significantly associated with the whole human value space in a sinusoidal waveform that was consistent with Schwartz's circular model of human values. These results suggest that it is useful to consider human values in the analyses of genetic contributions to personality traits. They also pave the way for an investigation of the biological mechanisms contributing to human value orientations. Journal Article Genes, Brain and Behavior 15 4 361 366 Wiley 1601-1848 Genetics, human values, neuroticism, personality,polygenic score 6 4 2016 2016-04-06 10.1111/gbb.12286 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University National Centre for Mental Health (NCMH); National Institute for Social Care and Health Research (NISCHR); Welsh Government, Wales. Grant Number: BR09; Medical Research Council (MRC). Grant Number: MR/K004360/1; MRC Centre for Neuropsychiatric Genetics and Genomics. Grant Number: G0800509 2021-12-29T15:32:40.5225864 2021-12-07T14:32:19.8377884 Faculty of Medicine, Health and Life Sciences School of Psychology George Zacharopoulos 1 Thomas M. Lancaster 2 Gregory R. Maio 3 David E. J. Linden 4 58968__21951__537aa28140594162b07ebbb835856b91.pdf 58968.pdf 2021-12-29T15:31:01.4884899 Output 344554 application/pdf Version of Record true © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title The genetics of neuroticism and human values
spellingShingle The genetics of neuroticism and human values
George Zacharopoulos
title_short The genetics of neuroticism and human values
title_full The genetics of neuroticism and human values
title_fullStr The genetics of neuroticism and human values
title_full_unstemmed The genetics of neuroticism and human values
title_sort The genetics of neuroticism and human values
author_id_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1
author_id_fullname_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1_***_George Zacharopoulos
author George Zacharopoulos
author2 George Zacharopoulos
Thomas M. Lancaster
Gregory R. Maio
David E. J. Linden
format Journal article
container_title Genes, Brain and Behavior
container_volume 15
container_issue 4
container_start_page 361
publishDate 2016
institution Swansea University
issn 1601-1848
doi_str_mv 10.1111/gbb.12286
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
active_str 0
description Human values and personality have been shown to share genetic variance in twin studies. However, there is a lack of evidence about the genetic components of this association. This study examined the interplay between genes, values and personality in the case of neuroticism, because polygenic scores were available for this personality trait. First, we replicated prior evidence of a positive association between the polygenic neuroticism score (PNS) and neuroticism. Second, we found that the PNS was significantly associated with the whole human value space in a sinusoidal waveform that was consistent with Schwartz's circular model of human values. These results suggest that it is useful to consider human values in the analyses of genetic contributions to personality traits. They also pave the way for an investigation of the biological mechanisms contributing to human value orientations.
published_date 2016-04-06T04:15:54Z
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score 10.999207

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