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Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy

Wenhui Li, Jin Huang, Nan Zhang, Kathrin Weidacker Orcid Logo, Jun Li, Valerie Voon, Chuansheng Wang, Chencheng Zhang

Frontiers in Psychiatry, Volume: 12

Swansea University Author: Kathrin Weidacker Orcid Logo

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DOI (Published version): 10.3389/fpsyt.2021.780208

Abstract

Objective: Abnormal selective attention to drug cues and negative affect is observed in patients with substance dependence, and it is closely associated with drug addiction and relapse. Methadone maintenance is an effective replacement therapy to treat heroin addiction, which significantly reduces t...

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Published in: Frontiers in Psychiatry
ISSN: 1664-0640
Published: Frontiers Media SA 2022
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2022-01-18T11:25:10.5492455</datestamp><bib-version>v2</bib-version><id>59172</id><entry>2022-01-13</entry><title>Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy</title><swanseaauthors><author><sid>4fed7fdf5381ec1a577001d6bd3d74d8</sid><ORCID>0000-0002-5742-6016</ORCID><firstname>Kathrin</firstname><surname>Weidacker</surname><name>Kathrin Weidacker</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-01-13</date><deptcode>HPS</deptcode><abstract>Objective: Abnormal selective attention to drug cues and negative affect is observed in patients with substance dependence, and it is closely associated with drug addiction and relapse. Methadone maintenance is an effective replacement therapy to treat heroin addiction, which significantly reduces the relapse rate. The present study examines whether the patients with opioid use disorder on chronic methadone maintenance therapy exhibit abnormal attentional bias to drug cues and negative-affective cues. Moreover, its relation to therapeutic and neuropsychological factors is also examined.Methods: Seventy-nine patients with opioid use disorder under chronic methadone maintenance therapy and 73 age-, sex-, and education-matched healthy controls were recruited and assessed for attentional bias to drug cues and negative affect using a dot-probe detection task. Correlational analysis was used to examine the relationships between the attentional bias and the demographic, therapeutic, and neuropsychological factors.Results: No significant overall patient-control group difference is observed in drug-related or negative-affective-related attentional bias scores. In the patient group, however, a significant negative correlation is found between the attentional bias scores to negative-affective cues and the duration of methadone treatment (p = 0.027), with the patients receiving longer methadone treatment showing less attentional avoidance to negative-affective cues. A significant positive correlation is found between the negative affect-induced bias and the impulsivity score (p = 0.006), with more impulsive patients showing higher attentional avoidance to negative affective cues than less impulsive patients. Additionally, the patients detect a smaller percentage of probe stimuli following the drug (p = 0.029) or negative-affective pictures (p = 0.009) than the healthy controls.Conclusion: The results of the present study indicate that the patients under chronic methadone maintenance therapy show normalized attentional bias to drug and negative-affective cues, confirming the involuntary attention of the patients is not abnormally captured by external drug or negative-affective clues. Our findings also highlight that the attentional avoidance of negative-affective cues is modulated by the duration of methadone treatment and the impulsivity level in the patients.</abstract><type>Journal Article</type><journal>Frontiers in Psychiatry</journal><volume>12</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Frontiers Media SA</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>1664-0640</issnElectronic><keywords>opioid addiction, methadone maintenance therapy, attentional bias, treatment duration, impulsivity,heroin</keywords><publishedDay>12</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-01-12</publishedDate><doi>10.3389/fpsyt.2021.780208</doi><url/><notes/><college>COLLEGE NANME</college><department>Psychology</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>HPS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>CZ was supported by the fellowship of the Shanghai Research Center for Brain Science and Brain-Inspired Intelligence and Shanghai Clinical Research Center for Mental Health (19MC1911100). VV was supported by Medical Research Council Senior Clinical Fellowship (MR/P008747/1).</funders><lastEdited>2022-01-18T11:25:10.5492455</lastEdited><Created>2022-01-13T11:57:48.1124131</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Psychology</level></path><authors><author><firstname>Wenhui</firstname><surname>Li</surname><order>1</order></author><author><firstname>Jin</firstname><surname>Huang</surname><order>2</order></author><author><firstname>Nan</firstname><surname>Zhang</surname><order>3</order></author><author><firstname>Kathrin</firstname><surname>Weidacker</surname><orcid>0000-0002-5742-6016</orcid><order>4</order></author><author><firstname>Jun</firstname><surname>Li</surname><order>5</order></author><author><firstname>Valerie</firstname><surname>Voon</surname><order>6</order></author><author><firstname>Chuansheng</firstname><surname>Wang</surname><order>7</order></author><author><firstname>Chencheng</firstname><surname>Zhang</surname><order>8</order></author></authors><documents><document><filename>59172__22163__4f9d7a9d21e7404bbabfd45bbd1a11ff.pdf</filename><originalFilename>59172.pdf</originalFilename><uploaded>2022-01-17T14:07:12.2504727</uploaded><type>Output</type><contentLength>1559839</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Copyright &#xA9; 2022 Li, Huang, Zhang, Weidacker, Li, Voon, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2022-01-18T11:25:10.5492455 v2 59172 2022-01-13 Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy 4fed7fdf5381ec1a577001d6bd3d74d8 0000-0002-5742-6016 Kathrin Weidacker Kathrin Weidacker true false 2022-01-13 HPS Objective: Abnormal selective attention to drug cues and negative affect is observed in patients with substance dependence, and it is closely associated with drug addiction and relapse. Methadone maintenance is an effective replacement therapy to treat heroin addiction, which significantly reduces the relapse rate. The present study examines whether the patients with opioid use disorder on chronic methadone maintenance therapy exhibit abnormal attentional bias to drug cues and negative-affective cues. Moreover, its relation to therapeutic and neuropsychological factors is also examined.Methods: Seventy-nine patients with opioid use disorder under chronic methadone maintenance therapy and 73 age-, sex-, and education-matched healthy controls were recruited and assessed for attentional bias to drug cues and negative affect using a dot-probe detection task. Correlational analysis was used to examine the relationships between the attentional bias and the demographic, therapeutic, and neuropsychological factors.Results: No significant overall patient-control group difference is observed in drug-related or negative-affective-related attentional bias scores. In the patient group, however, a significant negative correlation is found between the attentional bias scores to negative-affective cues and the duration of methadone treatment (p = 0.027), with the patients receiving longer methadone treatment showing less attentional avoidance to negative-affective cues. A significant positive correlation is found between the negative affect-induced bias and the impulsivity score (p = 0.006), with more impulsive patients showing higher attentional avoidance to negative affective cues than less impulsive patients. Additionally, the patients detect a smaller percentage of probe stimuli following the drug (p = 0.029) or negative-affective pictures (p = 0.009) than the healthy controls.Conclusion: The results of the present study indicate that the patients under chronic methadone maintenance therapy show normalized attentional bias to drug and negative-affective cues, confirming the involuntary attention of the patients is not abnormally captured by external drug or negative-affective clues. Our findings also highlight that the attentional avoidance of negative-affective cues is modulated by the duration of methadone treatment and the impulsivity level in the patients. Journal Article Frontiers in Psychiatry 12 Frontiers Media SA 1664-0640 opioid addiction, methadone maintenance therapy, attentional bias, treatment duration, impulsivity,heroin 12 1 2022 2022-01-12 10.3389/fpsyt.2021.780208 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University CZ was supported by the fellowship of the Shanghai Research Center for Brain Science and Brain-Inspired Intelligence and Shanghai Clinical Research Center for Mental Health (19MC1911100). VV was supported by Medical Research Council Senior Clinical Fellowship (MR/P008747/1). 2022-01-18T11:25:10.5492455 2022-01-13T11:57:48.1124131 Faculty of Medicine, Health and Life Sciences School of Psychology Wenhui Li 1 Jin Huang 2 Nan Zhang 3 Kathrin Weidacker 0000-0002-5742-6016 4 Jun Li 5 Valerie Voon 6 Chuansheng Wang 7 Chencheng Zhang 8 59172__22163__4f9d7a9d21e7404bbabfd45bbd1a11ff.pdf 59172.pdf 2022-01-17T14:07:12.2504727 Output 1559839 application/pdf Version of Record true Copyright © 2022 Li, Huang, Zhang, Weidacker, Li, Voon, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) true eng http://creativecommons.org/licenses/by/4.0/
title Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy
spellingShingle Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy
Kathrin Weidacker
title_short Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy
title_full Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy
title_fullStr Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy
title_full_unstemmed Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy
title_sort Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy
author_id_str_mv 4fed7fdf5381ec1a577001d6bd3d74d8
author_id_fullname_str_mv 4fed7fdf5381ec1a577001d6bd3d74d8_***_Kathrin Weidacker
author Kathrin Weidacker
author2 Wenhui Li
Jin Huang
Nan Zhang
Kathrin Weidacker
Jun Li
Valerie Voon
Chuansheng Wang
Chencheng Zhang
format Journal article
container_title Frontiers in Psychiatry
container_volume 12
publishDate 2022
institution Swansea University
issn 1664-0640
doi_str_mv 10.3389/fpsyt.2021.780208
publisher Frontiers Media SA
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
active_str 0
description Objective: Abnormal selective attention to drug cues and negative affect is observed in patients with substance dependence, and it is closely associated with drug addiction and relapse. Methadone maintenance is an effective replacement therapy to treat heroin addiction, which significantly reduces the relapse rate. The present study examines whether the patients with opioid use disorder on chronic methadone maintenance therapy exhibit abnormal attentional bias to drug cues and negative-affective cues. Moreover, its relation to therapeutic and neuropsychological factors is also examined.Methods: Seventy-nine patients with opioid use disorder under chronic methadone maintenance therapy and 73 age-, sex-, and education-matched healthy controls were recruited and assessed for attentional bias to drug cues and negative affect using a dot-probe detection task. Correlational analysis was used to examine the relationships between the attentional bias and the demographic, therapeutic, and neuropsychological factors.Results: No significant overall patient-control group difference is observed in drug-related or negative-affective-related attentional bias scores. In the patient group, however, a significant negative correlation is found between the attentional bias scores to negative-affective cues and the duration of methadone treatment (p = 0.027), with the patients receiving longer methadone treatment showing less attentional avoidance to negative-affective cues. A significant positive correlation is found between the negative affect-induced bias and the impulsivity score (p = 0.006), with more impulsive patients showing higher attentional avoidance to negative affective cues than less impulsive patients. Additionally, the patients detect a smaller percentage of probe stimuli following the drug (p = 0.029) or negative-affective pictures (p = 0.009) than the healthy controls.Conclusion: The results of the present study indicate that the patients under chronic methadone maintenance therapy show normalized attentional bias to drug and negative-affective cues, confirming the involuntary attention of the patients is not abnormally captured by external drug or negative-affective clues. Our findings also highlight that the attentional avoidance of negative-affective cues is modulated by the duration of methadone treatment and the impulsivity level in the patients.
published_date 2022-01-12T04:16:16Z
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