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Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization
Cognitive, Affective, and Behavioral Neuroscience, Volume: 22, Issue: 5, Pages: 1130 - 1144
Swansea University Author: Kathrin Weidacker
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DOI (Published version): 10.3758/s13415-021-00981-y
Abstract
The externalizing spectrum describes a range of heterogeneous personality traits and behavioral patterns, primarily characterized by antisocial behavior, disinhibition, and substance (mis)use. In psychopathology, abnormalities in neural threat, reward responses and the impulse-control system may be...
Published in: | Cognitive, Affective, and Behavioral Neuroscience |
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ISSN: | 1530-7026 1531-135X |
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Springer Science and Business Media LLC
2022
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Within the non-clinical range, mechanisms remain still unclear. In this fMRI-study, 61 healthy participants (31 men) from the higher versus lower range of the non-clinical variation in externalization (31 participants with high externalization) as assessed by the subscales disinhibition and meanness of the Triarchic-Psychopathy-Measure (TriPM) performed a monetary modified Taylor-Aggression-Paradigm (mTAP). This paradigm consisted of a mock competitive-reaction-time-task played against a fictional opponent with preprogrammed win- and lose-trials. In lose-trials, participants were provoked by subtraction of an amount of money between 0 and 90 cents. As a manipulation check, provocation induced a significant rise in behavioral aggression levels linked with an increased activation in the anterior cingulate cortex (ACC). High externalization predicted reduced ACC responses to provocation. However, high externalizing participants did not behave more aggressively than the low externalization group. Additionally, the high externalizing group showed a significantly lower positive affect while no group differences emerged for negative affect. In conclusion, high externalization in the non-clinical range was related to neural alterations in regions involved in affective decision-making as well as to changes in affect but did not lead to higher behavioral aggression levels in response to the mTAP. 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2022-10-18T16:05:21.4999965 v2 59287 2022-02-01 Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization 4fed7fdf5381ec1a577001d6bd3d74d8 0000-0002-5742-6016 Kathrin Weidacker Kathrin Weidacker true false 2022-02-01 HPS The externalizing spectrum describes a range of heterogeneous personality traits and behavioral patterns, primarily characterized by antisocial behavior, disinhibition, and substance (mis)use. In psychopathology, abnormalities in neural threat, reward responses and the impulse-control system may be responsible for these externalizing symptoms. Within the non-clinical range, mechanisms remain still unclear. In this fMRI-study, 61 healthy participants (31 men) from the higher versus lower range of the non-clinical variation in externalization (31 participants with high externalization) as assessed by the subscales disinhibition and meanness of the Triarchic-Psychopathy-Measure (TriPM) performed a monetary modified Taylor-Aggression-Paradigm (mTAP). This paradigm consisted of a mock competitive-reaction-time-task played against a fictional opponent with preprogrammed win- and lose-trials. In lose-trials, participants were provoked by subtraction of an amount of money between 0 and 90 cents. As a manipulation check, provocation induced a significant rise in behavioral aggression levels linked with an increased activation in the anterior cingulate cortex (ACC). High externalization predicted reduced ACC responses to provocation. However, high externalizing participants did not behave more aggressively than the low externalization group. Additionally, the high externalizing group showed a significantly lower positive affect while no group differences emerged for negative affect. In conclusion, high externalization in the non-clinical range was related to neural alterations in regions involved in affective decision-making as well as to changes in affect but did not lead to higher behavioral aggression levels in response to the mTAP. This is in line with previous findings suggesting that aberrations at multiple levels are essential for developing externalizing disorders. Journal Article Cognitive, Affective, and Behavioral Neuroscience 22 5 1130 1144 Springer Science and Business Media LLC 1530-7026 1531-135X Taylor Aggression Paradigm; Externalizing spectrum; fMRI; Anterior cingulate cortex 1 10 2022 2022-10-01 10.3758/s13415-021-00981-y COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University This work was supported by grant number KU 1401/6-1 assigned to Brigitte M. 591 Kudielka, Stefan Wüst, Hedwig Eisenbarth and Boris Schiffer funded by the German Research 592 Foundation (DFG). Gina-Isabelle Henze acknowledges support by the Hanns Seidel 593 Foundation. Open Access funding enabled and organized by Projekt DEAL. 2022-10-18T16:05:21.4999965 2022-02-01T11:39:56.7603824 Faculty of Medicine, Health and Life Sciences School of Psychology Julian Konzok 1 Gina-Isabelle Henze 2 Ludwig Kreuzpointner 3 Hannah L. Peter 4 Marina Giglberger 5 Christoph Bärtl 6 Claudia Massau 7 Christian Kärgel 8 Kathrin Weidacker 0000-0002-5742-6016 9 Boris Schiffer 10 Hedwig Eisenbarth 11 Stefan Wüst 12 Brigitte M. Kudielka 13 59287__22293__513d026ee3d44a3d9fe534700bf258f7.pdf 59287.pdf 2022-02-02T16:01:24.0207076 Output 1177791 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/ |
title |
Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization |
spellingShingle |
Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization Kathrin Weidacker |
title_short |
Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization |
title_full |
Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization |
title_fullStr |
Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization |
title_full_unstemmed |
Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization |
title_sort |
Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization |
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4fed7fdf5381ec1a577001d6bd3d74d8 |
author_id_fullname_str_mv |
4fed7fdf5381ec1a577001d6bd3d74d8_***_Kathrin Weidacker |
author |
Kathrin Weidacker |
author2 |
Julian Konzok Gina-Isabelle Henze Ludwig Kreuzpointner Hannah L. Peter Marina Giglberger Christoph Bärtl Claudia Massau Christian Kärgel Kathrin Weidacker Boris Schiffer Hedwig Eisenbarth Stefan Wüst Brigitte M. Kudielka |
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Cognitive, Affective, and Behavioral Neuroscience |
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Swansea University |
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1530-7026 1531-135X |
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10.3758/s13415-021-00981-y |
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Springer Science and Business Media LLC |
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Faculty of Medicine, Health and Life Sciences |
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description |
The externalizing spectrum describes a range of heterogeneous personality traits and behavioral patterns, primarily characterized by antisocial behavior, disinhibition, and substance (mis)use. In psychopathology, abnormalities in neural threat, reward responses and the impulse-control system may be responsible for these externalizing symptoms. Within the non-clinical range, mechanisms remain still unclear. In this fMRI-study, 61 healthy participants (31 men) from the higher versus lower range of the non-clinical variation in externalization (31 participants with high externalization) as assessed by the subscales disinhibition and meanness of the Triarchic-Psychopathy-Measure (TriPM) performed a monetary modified Taylor-Aggression-Paradigm (mTAP). This paradigm consisted of a mock competitive-reaction-time-task played against a fictional opponent with preprogrammed win- and lose-trials. In lose-trials, participants were provoked by subtraction of an amount of money between 0 and 90 cents. As a manipulation check, provocation induced a significant rise in behavioral aggression levels linked with an increased activation in the anterior cingulate cortex (ACC). High externalization predicted reduced ACC responses to provocation. However, high externalizing participants did not behave more aggressively than the low externalization group. Additionally, the high externalizing group showed a significantly lower positive affect while no group differences emerged for negative affect. In conclusion, high externalization in the non-clinical range was related to neural alterations in regions involved in affective decision-making as well as to changes in affect but did not lead to higher behavioral aggression levels in response to the mTAP. This is in line with previous findings suggesting that aberrations at multiple levels are essential for developing externalizing disorders. |
published_date |
2022-10-01T04:16:28Z |
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11.030869 |