No Cover Image

Journal article 154 views 6 downloads

Receptor-ligand diffusion-limited reaction rates on curved membranes

Rob Daniels Orcid Logo

Chemical Physics Letters, Volume: 795, Start page: 139516

Swansea University Author: Rob Daniels Orcid Logo

  • 59480.VOR.pdf

    PDF | Version of Record

    Distributed under the terms of a Creative Commons Attribution 4.0 (CC-BY) Licence.

    Download (575.11KB)

Abstract

We provide an expression for the diffusion-limited reaction rate on a curved surface, or membrane, in the perturbative deformation regime. This result is applied to the specific case of calculating the receptor-ligand association rate at membrane deforming, transmembrane receptor proteins, or inclus...

Full description

Published in: Chemical Physics Letters
ISSN: 0009-2614
Published: Elsevier BV 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa59480
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: We provide an expression for the diffusion-limited reaction rate on a curved surface, or membrane, in the perturbative deformation regime. This result is applied to the specific case of calculating the receptor-ligand association rate at membrane deforming, transmembrane receptor proteins, or inclusions. The dynamics of mechanochemical coupling between chemical activity and local membrane curvature is further investigated, and the effect of thermal membrane fluctuations is also discussed. It is found for transmembrane proteins, or inclusions, that their concomitant receptor-ligand reaction rates can be typically reduced by as much as 20% due to the effect of locally induced membrane curvature or geometry.
Keywords: Receptor, ligand, reaction rate, membrane, diffusion, curvature.
College: College of Engineering
Start Page: 139516