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Clinical Impact of Implementing a Nurse-Led Adverse Drug Reaction Profile in Older Adults Prescribed Multiple Medicines in UK Primary Care: A Study Protocol for a Cluster-Randomised Controlled Trial

Vera Logan Orcid Logo, Alex Bamsey, Neil Carter, David Hughes, Adam Turner Orcid Logo, Sue Jordan Orcid Logo

Pharmacy, Volume: 10, Issue: 3, Start page: 52

Swansea University Authors: Vera Logan Orcid Logo, Alex Bamsey, Neil Carter, David Hughes, Adam Turner Orcid Logo, Sue Jordan Orcid Logo

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Abstract

(1) Aims: Adverse drug reactions (ADRs) particularly affect older people prescribed multiple medicines. The professional bodies of nursing, medicine and pharmacy have issued guidelines on identification and management of ADRs; however, ADRs continue to account for ~10% unplanned hospital admissions...

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Published in: Pharmacy
ISSN: 2226-4787
Published: MDPI AG 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa59925
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Abstract: (1) Aims: Adverse drug reactions (ADRs) particularly affect older people prescribed multiple medicines. The professional bodies of nursing, medicine and pharmacy have issued guidelines on identification and management of ADRs; however, ADRs continue to account for ~10% unplanned hospital admissions in the UK. Current methods of ADR identification and management could be improved by multidisciplinary collaboration involving nurses. The aim of this study is to examine the impact of implementing the nurse-led Adverse Drug Reaction (ADRe) Profile in UK primary care. (2) Design: A pragmatic cluster-randomised controlled trial (RCT) followed by qualitative interviews in a sequential mixed-methods study. (3) Methods: For the cluster RCT, 60 patients aged ≥65 prescribed ≥5 regular medicines for long-term conditions will be recruited, 10 in each of 6 general practices. The intervention arm (n = 30) will complete the ADRe Profile, whilst the control participants (n = 30) continue to receive usual, standard care. Primary outcomes will include clinical impact on patients, benefit and prescription changes. On completion of the RCT, participants will be invited to semi-structured qualitative interviews, to evaluate the impact of the ADRe Profile from stakeholders’ perspectives, and to describe the contextual factors relevant to ADRe implementation. (4) Results: The findings of this study will evaluate the effectiveness of the ADRe Profile in identifying and resolving potential ADRs in primary care. Trial registration: This study was registered in ClinicalTrials.gov, registration number NCT04663360, date of registration—29 November 2021 (date of initial registration: 26 November 2020), protocol version 2, dated 8 January 2021
Item Description: Study Protocol. This article belongs to the Special Issue 10th Anniversary of Pharmacy—Advances in Pharmacy Education and Practice. Academic Editor: David Wright.
Keywords: drug-related side effects and adverse reactions; polypharmacy; primary health care; aging; nurses; randomised controlled trial
College: Swansea University Medical School
Funders: This research was funded by Swansea University (Research Excellence Scholarship), sponsor reference RIO 034-20 and received support from Health and Care Research Wales (ID 49076).
Issue: 3
Start Page: 52