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A single sensor controls large variations in zinc quotas in a marine cyanobacterium.

Alevtina Mikhaylina, Amira Z Ksibe, Rachael Wilkinson, Darbi Smith, Eleanor Marks, James P C Coverdale Orcid Logo, Vilmos Fülöp, David J Scanlan Orcid Logo, Claudia A Blindauer Orcid Logo

Nature Chemical Biology, Volume: 18, Pages: 869 - 877

Swansea University Author: Rachael Wilkinson

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DOI (Published version): 10.1038/s41589-022-01051-1

Abstract

Marine cyanobacteria are critical players in global nutrient cycles that crucially depend on trace metals in metalloenzymes, including zinc for CO fixation and phosphorus acquisition. How strains proliferating in the vast oligotrophic ocean gyres thrive at ultra-low zinc concentrations is currently...

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Published in: Nature Chemical Biology
ISSN: 1552-4469
Published: SpringerNature 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa60315
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spelling 2023-01-04T11:34:36.7481335 v2 60315 2022-06-24 A single sensor controls large variations in zinc quotas in a marine cyanobacterium. 81e346f0f7b208e6c7a76465799482ab Rachael Wilkinson Rachael Wilkinson true false 2022-06-24 SAS Marine cyanobacteria are critical players in global nutrient cycles that crucially depend on trace metals in metalloenzymes, including zinc for CO fixation and phosphorus acquisition. How strains proliferating in the vast oligotrophic ocean gyres thrive at ultra-low zinc concentrations is currently unknown. Using Synechococcus sp. WH8102 as a model we show that its zinc-sensor protein Zur differs from all other known bacterial Zur proteins in overall structure and the location of its sensory zinc site. Uniquely, Synechococcus Zur activates metallothionein gene expression, which supports cellular zinc quotas spanning two orders of magnitude. Thus, a single zinc sensor facilitates growth across pico- to micromolar zinc concentrations with the bonus of banking this precious resource. The resultant ability to grow well at both ultra-low and excess zinc, together with overall lower zinc requirements, likely contribute to the broad ecological distribution of Synechococcus across the global oceans. [Abstract copyright: © 2022. The Author(s).] Journal Article Nature Chemical Biology 18 869 877 SpringerNature 1552-4469 9 6 2022 2022-06-09 10.1038/s41589-022-01051-1 COLLEGE NANME Student Academic Services COLLEGE CODE SAS Swansea University Another institution paid the OA fee RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) Grant: BB/M003523/1 Grant: BB/M003523/1 RCUK | Natural Environment Research Council (NERC) Grant: NE/I00985X/1 Grant: NE/I00985X/1 2023-01-04T11:34:36.7481335 2022-06-24T11:43:52.1805279 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Alevtina Mikhaylina 1 Amira Z Ksibe 2 Rachael Wilkinson 3 Darbi Smith 4 Eleanor Marks 5 James P C Coverdale 0000-0002-7779-6620 6 Vilmos Fülöp 7 David J Scanlan 0000-0003-3093-4245 8 Claudia A Blindauer 0000-0001-8396-9332 9 60315__24390__22d494faae6d417f8664c5e421133d73.pdf 60315.VOR.pdf 2022-06-24T11:55:58.5335883 Output 19826773 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. true eng http://creativecommons.org/licenses/by/4.0/
title A single sensor controls large variations in zinc quotas in a marine cyanobacterium.
spellingShingle A single sensor controls large variations in zinc quotas in a marine cyanobacterium.
Rachael Wilkinson
title_short A single sensor controls large variations in zinc quotas in a marine cyanobacterium.
title_full A single sensor controls large variations in zinc quotas in a marine cyanobacterium.
title_fullStr A single sensor controls large variations in zinc quotas in a marine cyanobacterium.
title_full_unstemmed A single sensor controls large variations in zinc quotas in a marine cyanobacterium.
title_sort A single sensor controls large variations in zinc quotas in a marine cyanobacterium.
author_id_str_mv 81e346f0f7b208e6c7a76465799482ab
author_id_fullname_str_mv 81e346f0f7b208e6c7a76465799482ab_***_Rachael Wilkinson
author Rachael Wilkinson
author2 Alevtina Mikhaylina
Amira Z Ksibe
Rachael Wilkinson
Darbi Smith
Eleanor Marks
James P C Coverdale
Vilmos Fülöp
David J Scanlan
Claudia A Blindauer
format Journal article
container_title Nature Chemical Biology
container_volume 18
container_start_page 869
publishDate 2022
institution Swansea University
issn 1552-4469
doi_str_mv 10.1038/s41589-022-01051-1
publisher SpringerNature
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description Marine cyanobacteria are critical players in global nutrient cycles that crucially depend on trace metals in metalloenzymes, including zinc for CO fixation and phosphorus acquisition. How strains proliferating in the vast oligotrophic ocean gyres thrive at ultra-low zinc concentrations is currently unknown. Using Synechococcus sp. WH8102 as a model we show that its zinc-sensor protein Zur differs from all other known bacterial Zur proteins in overall structure and the location of its sensory zinc site. Uniquely, Synechococcus Zur activates metallothionein gene expression, which supports cellular zinc quotas spanning two orders of magnitude. Thus, a single zinc sensor facilitates growth across pico- to micromolar zinc concentrations with the bonus of banking this precious resource. The resultant ability to grow well at both ultra-low and excess zinc, together with overall lower zinc requirements, likely contribute to the broad ecological distribution of Synechococcus across the global oceans. [Abstract copyright: © 2022. The Author(s).]
published_date 2022-06-09T05:03:27Z
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